Homocysteine: An activity marker in Behçet's disease?

Sarican, Tuncay; Ayabakan, Hatice; Türkmen, Sembol; Kalaslıoğlu, Vesile; Baran, Fehmi; Yenice, Necati

doi:10.1016/j.jdermsci.2006.11.008

Cited by 38 publications

(29 citation statements)

References 33 publications

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“…Mean serum tHcy levels were higher in the active stage than in the inactive stage. 34 However, these biomarkers are not as cheap and easy to use routinely as the N/L ratio. In conclusion, we have shown for the first time that patients with BD have a higher N/L ratio than that of control participants.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil–Lymphocyte Ratio and Carotid–Intima Media Thickness in Patients With Behçet Disease Without Cardiovascular Involvement

Öztürk

Balta

et al. 2014

Angiology

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Behçet disease (BD) is associated with endothelial dysfunction and chronic inflammation. The neutrophil-lymphocyte (N/L) ratio and carotid intima-media thickness (cIMT) are markers of inflammation and vascular risk, respectively. We assessed the relationship between cIMT values and N/L ratio in BD (65 patients and 62 control participants). There were statistically significant differences in N/L ratios and cIMT values between the patients with BD and control group (P < .001). There were moderate positive correlations between cIMT value, C-reactive protein, and N/L ratio in patients with BD. Receiver-operating characteristic curve analysis suggested that the optimum N/L ratio cutoff point for patients with BD was 1.29, with a sensitivity, specificity, negative predictive value, and positive predictive value of 97, 77, 96, and 75%, respectively (area under curve: 0.691, 95% confidence interval = 0.600-0.782, P < .001). The N/L ratio may be a useful index of BD activity.

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Section: Discussionmentioning

confidence: 99%

Neutrophil–Lymphocyte Ratio and Carotid–Intima Media Thickness in Patients With Behçet Disease Without Cardiovascular Involvement

Öztürk

Balta

et al. 2014

Angiology

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“…Hcy generates superoxide and hydrogen peroxide, both of which have been linked to endothelial damage . Hcy-induced vascular problems are thought to be multifactorial, including direct Hcy damage to the endothelium, enhanced lipid peroxidation and increased platelet aggregation by the effects on the coagulation system Sarican et al, 2007). Hcy has been shown in vivo and in vitro to promote inflammatory process such as the adhesion of neutrophils to endothelial cells as well as the release of the inflammatory cytokine IL-8 and monocyte chemoattractant protein-1 (MPC-1) (Koga et al, 2002).…”

Section: Pathogenesis Of Behcet's Disease and Thrombosismentioning

confidence: 99%

“…Hcy was shown to promote TNF-α mediated induction of vascular cell adhesion molecule-1 (VCAM-1) in endothelial cells (Silverman et al, 2002). Some studies have shown hyperhomocysteinemia as a correctable risk factor for thrombosis in BD (Kartal Durmazlar et al, 2008aOmar et al, 2007;Ozdemir et al, 2004;Er et al, 2002;Sarican et al, 2007). In a recent work, thrombogenesis in BD is discussed through the concept of Virchow's triad of venous thrombosis (La Regina et al, 2010).…”

Section: Pathogenesis Of Behcet's Disease and Thrombosismentioning

confidence: 99%

Venous Thrombosis in Behcet’s Disease

Durmazlar¹

2012

Venous Thrombosis - Principles and Practice

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“…Una prova indiretta di questo meccanismo è anche il mancato riscontro di anomalie della coagulazione in pazienti con MB con tromboflebiti [10]. La presenza di valori elevati di omocisteina circolante è correlata con l'attività di malattia e non sarebbe quindi da associare alla trombofilia di questi pazienti [11]. Il primo passo dell'evento trombotico sarebbe l'espressione di fattore tissutale (FT) attivato che "in vivo" è il principale responsabile dell'innesco di entrambe le vie della coagulazione, che conzioni di una certa gravità della MB, solitamente a dosi medioelevate (0,5-1 mg/kg/die) per ridurre l'attività infiammatoria e quindi a dosi di mantenimento (<10 mg/die) per prevenire le recidive.…”

Section: Manifestazioni Vascolariunclassified

La malattia di Behçet

Marchesoni

2010

Arch Ortop Reumatol

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A 51-year-old man with Behçet's disease complained of fever, dry cough and dyspnea during exertion. Chest CT showed ground glass opacities with interstitial septal thickening in both lungs. Bronchoalveolar lavage (BAL) revealed amorphous and lipoproteinaceous material that was periodic acid-Schiff (PAS) stain positive. Transbronchial biopsy specimen demonstrated PAS positive alveolar eosinophilic material consistent with pulmonary alveolar proteinosis. Serum anti-granulo-cyte-macrophage colony stimulating factor (GM-CSF) anti-body was negative. Recent studies have reported anti-GM-CSF not present in the the serum of patients with secondary pulmonary alveolar proteinosis (PAP) but they have not reported so in patients with idiopathic PAP. We report a case of alveolar proteinosis in the setting of Behçet's disease with spontaneous remission. RIASSUNTO Un paziente maschio di 51 anni con malattia di Behçet riferiva febbre, tosse secca e dispnea da sforzo. Alla TAC torace si evi-denziavano opacità a vetro smeriglio con inspessimento dei setti interstiziali in entrambi i polmoni. Il lavaggio broncoal-veolare ha recuperato materiale amorfo, lipoproteinaceo, po-sitivo alla colorazione con acido periodico-Schiff (PAS). La biopsia transbronchiale dimostrava materiale alveolare eosi-nofilo PAS positivo, compatibile con una proteinosi endoal-veolare polmonare. Il tasso serico di anticorpi anti fattore sti-molante la colonia dei granulociti e macrofagi umani (GM-CSF) era negativo. Studi recenti hanno riportato l'assenza di anti-GM-CSF nei pazienti con proteinosi endoalveolare se-condaria, a differenza di quanto avviene nelle forme idiopati-che. Viene qui descritto un caso di proteinosi alveolare in cor-so di malattia di Behçet a remissione spontanea. Parole chiave: Anticorpo anti fattore stimolante la colonia dei granulociti e macrofagi umani, malattia di Behçet, proteinosi endoalveolare.

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Homocysteine: An activity marker in Behçet's disease?

Cited by 38 publications

References 33 publications

Neutrophil–Lymphocyte Ratio and Carotid–Intima Media Thickness in Patients With Behçet Disease Without Cardiovascular Involvement

Neutrophil–Lymphocyte Ratio and Carotid–Intima Media Thickness in Patients With Behçet Disease Without Cardiovascular Involvement

Venous Thrombosis in Behcet’s Disease

La malattia di Behçet

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