Homocysteine is a marker for metabolic syndrome and atherosclerosis

Sreckovic, B.; Sreckovic, Vesna Dimitrijevic; Soldatović, Ivan; Čolak, Emina; Šumarac-Dumanović, Mirjana; Janeski, Hristina; Janeski, Nenad; Gačić, Jasna; Mrdović, Igor

doi:10.1016/j.dsx.2016.08.026

Cited by 85 publications

(72 citation statements)

References 28 publications

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“…Hp might be further involved in neurodegenerative disorders' pathophysiology by promoting in MetS‐related platelet‐leukocyte aggregation proposed to play pathophysiologic roles in AD; producing ROS and circulating lipid peroxides involved in the AD pathophysiology; causing the development of cross‐mimicry between endothelial and Hp antigens; increasing homocysteine, a risk factor for dementia and AD, implicated in endothelial damage and neurodegeneration via oxidative injury in these diseases; or influencing the apoptotic process, an important form of cell death in AD …”

Section: Helicobacter Pylori and Ad Linkage: Main Hypothesismentioning

confidence: 99%

Review: Impact of Helicobacter pylori on Alzheimer's disease: What do we know so far?

et al. 2017

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Section: Helicobacter Pylori and Ad Linkage: Main Hypothesismentioning

confidence: 99%

Review: Impact of Helicobacter pylori on Alzheimer's disease: What do we know so far?

et al. 2017

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“…In the context of cardiovascular diseases, homocysteine (Hcy) is an important indicator. It is an independent risk factor of their development and a marker of the amplification of atherosclerotic changes [10].…”

Section: Introductionmentioning

confidence: 99%

Nutritional Deficiencies, Bariatric Surgery, and Serum Homocysteine Level: Review of Current Literature

Komorniak

Szczuko

Kowalewski³

et al. 2019

OBES SURG

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Obesity is currently one of the biggest global health problems. In the case of severe obesity, bariatric surgeries are considered to be the most important method of treatment. The 2 most commonly performed bariatric surgery procedures include Roux-en-Y gastric bypass and sleeve gastrectomy. However, these methods are not free from complications, and the most common ones (moderately long or long term) are micronutrient deficiencies. The deficiency of vitamins B6, B12, and folic acid as cofactors of the folate cycle contributes to the development of hyperhomocysteinemia. It seems that apart from nutritional factors, there are other aspects that have a significant influence on the concentration of homocysteine in blood, such as the type of conducted bariatric surgery, the post-surgical concentration of betaine and creatinine, and the clearance of methionine (i.e., the mutations of the gene that encodes the MTHFR reductase as well as other genes associated with the process of methylation, e.g., methionine synthase). Their presence might be one of the causes of the increased concentration of homocysteine after surgery despite the fact that patients take vitamin-mineral supplementation.

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“…Aggregation and oxidation of the deposited lipids in the intima leads to the generation of modified lipid moieties (minimally- Koening et al 2011;Minamisawa et al 2016;Mittal et al 2014;Sreckovic et al 2016). …”

Section: Introductionmentioning

confidence: 99%

The role of damage- and pathogen-associated molecular patterns in inflammation-mediated vulnerability of atherosclerotic plaques

Rai

Agrawal

2017

Can. J. Physiol. Pharmacol.

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Homocysteine is a marker for metabolic syndrome and atherosclerosis

Cited by 85 publications

References 28 publications

Review: Impact of Helicobacter pylori on Alzheimer's disease: What do we know so far?

Review: Impact of Helicobacter pylori on Alzheimer's disease: What do we know so far?

Nutritional Deficiencies, Bariatric Surgery, and Serum Homocysteine Level: Review of Current Literature

The role of damage- and pathogen-associated molecular patterns in inflammation-mediated vulnerability of atherosclerotic plaques

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