Homogeneous Catalysts for Hydrogenative PHIP Used in Biomedical Applications
Mai T. Huynh,
Zoltan Kovacs
Abstract:At present, two competing hyperpolarization (HP) techniques, dissolution dynamic nuclear polarization (DNP) and parahydrogen (para‐H2) induced polarization (PHIP), can generate sufficiently high liquid state 13C signal enhancement for in vivo studies. PHIP utilizes the singlet spin state of para‐H2 to create non‐equilibrium spin populations. In hydrogenative PHIP, para‐H2 is irreversibly added to unsaturated precursors, typically in the presence of a homogeneous catalyst. The hydrogenation catalyst plays a cru… Show more
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