Homogeneous distribution of fatty ester‐based active cosmetic ingredients in hydrophilic thin films by means of nanodispersion

Munnier, Emilie; Assaad, Almar Al; David, Stéphanie; Mahut, Frédéric; Vayer, Marylène; Gheluwe, Louise Van; Yvergnaux, Florent; Sinturel, Christophe; Soucé, Martin; Chourpa, Igor; Bonnier, Franck

doi:10.1111/ics.12652

Cited by 9 publications

(17 citation statements)

References 34 publications

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“…The PVOH spectra indicated the distinct peaks at 1445 cm −1 for CH bending and OH bending, 1376 cm −1 for CH bending and OH bending, 1146 cm −1 for C–C and C–O stretching, 1097 cm −1 for C–O stretching and OH bending, 918 cm −1 for C–C stretching, and 857 cm −1 for C–C–O stretching, as informed in previous works [ 97 , 98 , 99 , 100 ].…”

Section: Resultssupporting

confidence: 76%

Adsorption of Paraquat by Poly(Vinyl Alcohol)-Cyclodextrin Nanosponges

2021

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The contamination of hydrosoluble pesticides in water could generate a serious problem for biotic and abiotic components. The removal of a hazardous agrochemical (paraquat) from water was achieved by adsorption processes using poly(vinyl alcohol)-cyclodextrin nanosponges, which were prepared with various formulations via the crosslinking between citric acid and β-cyclodextrin in the presence of poly(vinyl alcohol). The physicochemical properties of nanosponges were also characterized by different techniques, such as gravimetry, thermogravimetry, microscopy (SEM and Stereo), spectroscopy (UV-visible, NMR, ATR-FTIR, and Raman), acid-base titration, BET surface area analysis, X-ray diffraction, and ion exchange capacity. The C10D-P2 nanosponges displayed 60.2% yield, 3.14 mmol/g COOH groups, 0.335 mmol/g β-CD content, 96.4% swelling, 94.5% paraquat removal, 0.1766 m2 g−1 specific surface area, and 5.2 × 10−4 cm3 g−1 pore volume. The presence of particular peaks referring to specific functional groups on spectroscopic spectra confirmed the successful polycondensation on the reticulated nanosponges. The pseudo second-order model (with R2 = 0.9998) and Langmuir isotherm (with R2 = 0.9979) was suitable for kinetics and isotherm using 180 min of contact time and a pH of 6.5. The maximum adsorption capacity was calculated at 112.2 mg/g. Finally, the recyclability of these nanosponges was 90.3% of paraquat removal after five regeneration times.

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Section: Resultssupporting

confidence: 76%

Adsorption of Paraquat by Poly(Vinyl Alcohol)-Cyclodextrin Nanosponges

2021

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“…Nanoformulation of PHE (NanoPHE: NanoPHE were prepared by a green emulsionsolvent evaporation process assisted by ultrasound, as described in a previous study [14]. Briefly, the aqueous phase was prepared by dissolving 600 mg of Pluronic ® F127 in 10.5 g of ultrapure water.…”

Section: Sample Preparationmentioning

confidence: 99%

“…This phenomenon is particularly observed for hydrophobic AI dispersed in a hydrophilic film. To prevent the precipitation of AI, effective precipitation inhibitors [13] can be added to the mixture, or the hydrophobic AI can be encapsulated [14].…”

Section: Introductionmentioning

confidence: 99%

“…Fourier transform infrared spectroscopy (FTIR) has also been used for the characterisation of films [1,15] and or to identify the molecular interactions between active ingredients and the other constituent components of films [16,19]. Use of Raman spectroscopy has been reported for study the composition of various thin polymer films [14,20,21]. Most studies have relied on point measurements [1,15,[19][20][21], whereas coupling the molecular specificity of the analysis with the micrometric spatial resolution of Raman confocal microscope offers a powerful non-destructive tool to study the local distribution of AI in cosmetic films.…”

Section: Introductionmentioning

confidence: 99%

“…More recently, a study using Raman cartography highlighted that hydrophobic compounds from Punica granatum seed oil hydroxyphenethyl esters (PHE) stabilised in a poloxamer-based nanosystem showed very homogeneous distribution in hydrophilic PVA films compared to the free form introduced as an ethanol solution [14]. While quantitative analysis of AI concentrations in cosmetic and pharmaceutical products using Raman spectroscopy is increasingly documented for solutions and semi-solids forms (gels, cream) [29][30][31], application of the technique to solid complex mixtures remains largely limited to semi-quantitative analysis [32][33][34].…”

Section: Introductionmentioning

confidence: 99%

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Confocal Raman Spectroscopic Imaging for Evaluation of Distribution of Nano-Formulated Hydrophobic Active Cosmetic Ingredients in Hydrophilic Films

et al. 2021

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Film-forming systems are highly relevant to the topical administration of active ingredients (AI) to the body. Enhanced contact with the skin can increase the efficacy of delivery and penetration during prolonged exposure. However, after the evaporation of volatile solvents to form a thin film, the distribution of the ingredient should remain homogenous in order to ensure the effectiveness of the formula. This is especially critical for the use of hydrophobic molecules that have poor solubility in hydrophilic films. In order to address this concern, hydroxyphenethyl esters (PHE) of Punica granatum seed oil were prepared as a nanosuspension stabilised by poloxamers (NanoPHE). NanoPHE was then added to a formulation containing polyvinyl alcohol (PVA) as a film forming agent, Glycerol as a plasticiser and an antimicrobial agent, SepicideTM HB. Despite their reliability, reference methods such as high-performance liquid chromatography are increasingly challenged due to the need for consumables and solvents, which is contrary to current concerns about green industry in the cosmetics field. Moreover, such methods fail to provide spatially resolved chemical information. In order to investigate the distribution of ingredients in the dried film, Confocal Raman imaging (CRI) coupled to Non-negatively Constrained Least Squares (NCLS) analysis was used. The reconstructed heat maps from a range of films containing systematically varying PHE concentrations highlighted the changes in spectral contribution from each of the ingredients. First, using NCLS scores it was demonstrated that the distributions of PVA, Glycerol, SepicideTM HB and PHE were homogenous, with respective relative standard deviations (RSD) of 3.33%, 2.48%, 2.72% and 6.27%. Second, the respective relationships between ingredient concentrations in the films and their Raman responses, and the spectral abundance were established. Finally, a model for absolute quantification for PHE was be constructed using the percentage of spectral abundance. The prepared %w/w concentrations regressed against predicted %w/w concentrations, displaying high correlation (R2 = 0.995), while the Root Mean Squared Error (0.0869% w/w PHE) confirmed the precision of the analysis. The mean percent relative error of 3.75% indicates the accuracy to which the concentration in dried films could be determined, further supporting the suitability of CRI for analysis of composite solid film matrix. Ultimately, it was demonstrated that nanoformulation of hydrophobic PHE provides homogenous distribution in PVA based film-forming systems independent of the concentration of NanoPHE used in the formula.

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Gelatin Methacryloyl (GelMA)-Based Biomaterial Inks: Process Science for 3D/4D Printing and Current Status

Das,

Jegadeesan,

Basu

2024

Biomacromolecules

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Tissue engineering for injured tissue replacement and regeneration has been a subject of investigation over the last 30 years, and there has been considerable interest in using additive manufacturing to achieve these goals. Despite such efforts, many key questions remain unanswered, particularly in the area of biomaterial selection for these applications as well as quantitative understanding of the process science. The strategic utilization of biological macromolecules provides a versatile approach to meet diverse requirements in 3D printing, such as printability, buildability, and biocompatibility. These molecules play a pivotal role in both physical and chemical cross-linking processes throughout the biofabrication, contributing significantly to the overall success of the 3D printing process. Among the several bioprintable materials, gelatin methacryloyl (GelMA) has been widely utilized for diverse tissue engineering applications, with some degree of success. In this context, this review will discuss the key bioengineering approaches to identify the gelation and cross-linking strategies that are appropriate to control the rheology, printability, and buildability of biomaterial inks. This review will focus on the GelMA as the structural (scaffold) biomaterial for different tissues and as a potential carrier vehicle for the transport of living cells as well as their maintenance and viability in the physiological system. Recognizing the importance of printability toward shape fidelity and biophysical properties, a major focus in this review has been to discuss the qualitative and quantitative impact of the key factors, including microrheological, viscoelastic, gelation, shear thinning properties of biomaterial inks, and printing parameters, in particular, reference to 3D extrusion printing of GelMA-based biomaterial inks. Specifically, we emphasize the different possibilities to regulate mechanical, swelling, biodegradation, and cellular functionalities of GelMA-based bio(material) inks, by hybridization techniques, including different synthetic and natural biopolymers, inorganic nanofillers, and microcarriers. At the close, the potential possibility of the integration of experimental data sets and artificial intelligence/machine learning approaches is emphasized to predict the printability, shape fidelity, or biophysical properties of GelMA bio(material) inks for clinically relevant tissues.

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Homogeneous distribution of fatty ester‐based active cosmetic ingredients in hydrophilic thin films by means of nanodispersion

Cited by 9 publications

References 34 publications

Adsorption of Paraquat by Poly(Vinyl Alcohol)-Cyclodextrin Nanosponges

Adsorption of Paraquat by Poly(Vinyl Alcohol)-Cyclodextrin Nanosponges

Confocal Raman Spectroscopic Imaging for Evaluation of Distribution of Nano-Formulated Hydrophobic Active Cosmetic Ingredients in Hydrophilic Films

Gelatin Methacryloyl (GelMA)-Based Biomaterial Inks: Process Science for 3D/4D Printing and Current Status

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