This paper studies extension groups between certain Weyl modules for the algebraic group GL n over the integers. Main results include: (1) a complete determination of Ext groups between Weyl modules whose highest weights differ by a single root and (2) determination of Ext 1 between an exterior power of the defining representation and any Weyl module. The significance of these results for modular representation theory of GL n is discussed in several remarks. Notably the first result leads to a calculation of Ext groups between neighboring Weyl modules for GL n and also recovers the GL n case of a recent result of Andersen. Some generalities about Ext groups between Weyl modules and a brief overview of known results about these groups are also included.