Hopea odorata Extract Can Efficiently Kill Breast Cancer Cells and Cancer Stem-Like Cells in Three-Dimensional Culture More Than in Monolayer Cell Culture

Phan, Ngoc Kim; Pham, Khuong Duy; Minh, Phong Le; Nguyen, Manh Duc; Kim, Ngoc Phan; Truong, Kiet Dinh; Pham, Phuc Van

doi:10.1007/5584_2020_524

Cited by 4 publications

(3 citation statements)

References 30 publications

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“…We identified a total of 42 publications [ 16 , 19 , 22 , 23 , 30 , 41 , 42 , 45 , 49 , 52 , 56 , 59 , 61 , 64 , 68 , 72 , 74 , 80 , 85 , 89 , 100 , 101 , 102 , 103 , 105 , 106 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 ] comparing cell response to chemotherapy and other interventions between 2D and 3D in vitro tumour models, using a variety of anticancer agents and taking into account any publications which involved more than one type of anticancer agents, yielding in total 85 separate findings, including 79 outcomes concerning chemotherapy agents, three involving radiotherapy, and a further five exploring natural compound agents such as orange-peel flavones. The definitions for drug response varied throughout the studies in terms of markers used and duration over which drug responses were measured.…”

Section: Resultsmentioning

confidence: 99%

The Role of Biomimetic Hypoxia on Cancer Cell Behaviour in 3D Models: A Systematic Review

Liu

Mohri

Alsheikh

et al. 2021

Cancers

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The development of biomimetic, human tissue models is recognized as being an important step for transitioning in vitro research findings to the native in vivo response. Oftentimes, 2D models lack the necessary complexity to truly recapitulate cellular responses. The introduction of physiological features into 3D models informs us of how each component feature alters specific cellular response. We conducted a systematic review of research papers where the focus was the introduction of key biomimetic features into in vitro models of cancer, including 3D culture and hypoxia. We analysed outcomes from these and compiled our findings into distinct groupings to ascertain which biomimetic parameters correlated with specific responses. We found a number of biomimetic features which primed cancer cells to respond in a manner which matched in vivo response.

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Section: Resultsmentioning

confidence: 99%

The Role of Biomimetic Hypoxia on Cancer Cell Behaviour in 3D Models: A Systematic Review

Liu

Mohri

Alsheikh

et al. 2021

Cancers

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“…Although the traditional therapies including surgery, radiotherapy, chemotherapy, and hormone therapy have improved the survival rate of patients with breast cancer, recurrence and metastasis are still unavoidable [ 42 , 43 , 44 ]. Cancer stem-like cells (CS-like cells) are considered to be the main cause of breast cancer recurrence and drug resistance, which makes it a potential target for the new cancer treatment strategies [ 45 , 46 , 47 ]. It has been reported that breast CS-like cells are enriched by chemotherapy and radiotherapy, indicating that CS-like cells have therapy resistance [ 48 , 49 ].…”

Section: Anti-tumor Role Of Flubendazole In Breast Cancermentioning

confidence: 99%

Flubendazole Plays an Important Anti-Tumor Role in Different Types of Cancers

Chen

Ding

Liu

et al. 2022

IJMS

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Flubendazole, belonging to benzimidazole, is a broad-spectrum insect repellent and has been repurposed as a promising anticancer drug. In recent years, many studies have shown that flubendazole plays an anti-tumor role in different types of cancers, including breast cancer, melanoma, prostate cancer, colorectal cancer, and lung cancer. Although the anti-tumor mechanism of flubendazole has been studied, it has not been fully understood. In this review, we summarized the recent studies regarding the anti-tumor effects of flubendazole in different types of cancers and analyzed the related mechanisms, in order to provide the theoretical reference for further studies in the future.

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“…Aldehyde dehydrogenase (ALDH)‐positive BCSCs have a significant amount of Notch‐1, a Notch signaling receptor that stimulates epithelial‐mesenchymal transition (EMT). When Psoralidin represses Notch‐1, however, the stimulating impact is inhibited (Phan et al, 2020).…”

Section: Signaling Pathways In Pathogenesis Of Bcmentioning

confidence: 99%

Role of Medicinal plant‐derived Nutraceuticals as a potential target for the treatment of breast cancer

Alharbi

Almalki

Makeen

et al. 2022

Journal of Food Biochemistry

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Breast cancer (BC) is one of the most challenging cancers to treat, accounting for many cancer‐related deaths. Over some years, chemotherapy, hormone treatment, radiation, and surgeries have been used to treat cancer. Unfortunately, these treatment options are unsuccessful due to crucial adverse reactions and multidrug tolerance/resistance. Although it is clear that substances in the nutraceuticals category have a lot of anti‐cancer activity, using a supplementary therapy strategy, in this case, could be very beneficial. Nutraceuticals are therapeutic agents, which are nutrients that have drug‐like characteristics and can be used to treat diseases. Plant nutraceuticals categorized into polyphenols, terpenoids, vitamins, alkaloids, and flavonoids are part of health food products, that have great potential for combating BC. Nutraceuticals can reduce BC's severity, limit malignant cell growth, and modify cancer‐related mechanisms. Nutraceuticals acting by attenuating Hedgehog, Nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF‐κB), Notch, and Wnt/β‐catenin signaling are the main pathways in controlling the self‐renewal of breast cancer stem cells (BCSCs). This article reviews some important nutraceuticals and their modes of action, which can be very powerful versus BC. Practical applications Nutraceuticals' importance to the control and diagnosis of breast cancer is undeniable and cannot be overlooked. Natural dietary compounds have a wide range of uses and have been used in traditional medicine. In addition, these natural chemicals can enhance the effectiveness of other traditional medicines. They may also be used as a treatment process independently because of their capacity to affect several cancer pathways. This study highlights a variety of natural chemicals, and their mechanisms of action, routes, synergistic effects, and future potentials are all examined.

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Hopea odorata Extract Can Efficiently Kill Breast Cancer Cells and Cancer Stem-Like Cells in Three-Dimensional Culture More Than in Monolayer Cell Culture

Cited by 4 publications

References 30 publications

The Role of Biomimetic Hypoxia on Cancer Cell Behaviour in 3D Models: A Systematic Review

The Role of Biomimetic Hypoxia on Cancer Cell Behaviour in 3D Models: A Systematic Review

Flubendazole Plays an Important Anti-Tumor Role in Different Types of Cancers

Role of Medicinal plant‐derived Nutraceuticals as a potential target for the treatment of breast cancer

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