Horizontally Aligned Carbon Nanotubes on a Quartz Substrate for Chemical and Biological Sensing

Okuda, Satoshi; Okamoto, Shogo; Ohno, Yasuhide; Maehashi, Kenzo; Inoue, Kōichi; Matsumoto, Kazuhiko

doi:10.1021/jp301542w

Cited by 46 publications

(49 citation statements)

References 59 publications

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“…One-dimensional (1D) nanostructures such as carbon nanotubes and nanowires (NWs) have been demonstrated for real-time detection of a variety of bioactive molecules with ultrasensitivity from nM to fM level101112131415161718. However, to date, few are capable of reliable, quantitative real-time kinetic measurement because of high variations in device characteristics and restriction by planar complementary metal-oxide semiconductor nanofabrication processes19.…”

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confidence: 99%

Real-time reliable determination of binding kinetics of DNA hybridization using a multi-channel graphene biosensor

et al. 2017

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Reliable determination of binding kinetics and affinity of DNA hybridization and single-base mismatches plays an essential role in systems biology, personalized and precision medicine. The standard tools are optical-based sensors that are difficult to operate in low cost and to miniaturize for high-throughput measurement. Biosensors based on nanowire field-effect transistors have been developed, but reliable and cost-effective fabrication remains a challenge. Here, we demonstrate that a graphene single-crystal domain patterned into multiple channels can measure time- and concentration-dependent DNA hybridization kinetics and affinity reliably and sensitively, with a detection limit of 10 pM for DNA. It can distinguish single-base mutations quantitatively in real time. An analytical model is developed to estimate probe density, efficiency of hybridization and the maximum sensor response. The results suggest a promising future for cost-effective, high-throughput screening of drug candidates, genetic variations and disease biomarkers by using an integrated, miniaturized, all-electrical multiplexed, graphene-based DNA array.

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confidence: 99%

Real-time reliable determination of binding kinetics of DNA hybridization using a multi-channel graphene biosensor

et al. 2017

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“…In recent years, the significance of biological sensors using nanomaterials, such as silicon nanowires [7,8], carbon nanotubes [9,10], and graphene [11,12], has drawn significant attention to scientific research owing to its unique physical and chemical properties, such as surface effect and microsize effect. It is expected that these biosensors can be used as nextgeneration diagnostic chips for the future, which will play an increasingly important role in life science research and medical testing.…”

Section: Introductionmentioning

confidence: 99%

RNA Detection Based on Graphene Field-Effect Transistor Biosensor

Tian

Zhang

et al. 2018

Advances in Condensed Matter Physics

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Graphene has attracted much attention in biosensing applications due to its unique properties. In this paper, the monolayer graphene was grown by chemical vapor deposition (CVD) method. Using the graphene as the electric channel, we have fabricated a graphene field-effect transistor (G-FET) biosensor that can be used for label-free detection of RNA. Compared with conventional method, the G-FET RNA biosensor can be run in low cost, be time-saving, and be miniaturized for RNA measurement. The sensors show high performance and achieve the RNA detection sensitivity as low as 0.1 fM, which is two orders of magnitude lower than the previously reports. Moreover, the G-FET biosensor can readily distinguish target RNA from noncomplementary RNA, showing high selectivity for RNA detection. The developed G-FET RNA biosensor with high sensitivity, fast analysis speed, and simple operation may provide a new feasible direction for RNA research and biosensing.

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“…In particular, CNT network thin film transistors (CN-TFTs) have been explored for a wide range of applications such as flexible displays, sensors, antennas, etc. [2,4,[7][8][9][10][11][12][13]. Significant efforts have been made in recent years aimed at overcoming fabrication challenges to improve the performance of these devices [3,[14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

High field breakdown characteristics of carbon nanotube thin film transistors

Gupta¹,

Behnam²,

Lian³

et al. 2013

Nanotechnology

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The high-field properties of carbon nanotube (CNT) network thin film transistors (CN-TFTs) are important for their practical operation, and for understanding their reliability. Using a combination of experimental and computational techniques we show how the channel geometry (length L C and width W C ) and network morphology (average CNT length L t and alignment angle distribution θ) affect heat dissipation and high-field breakdown in such devices. The results suggest that when W C ≥ L t , the breakdown voltage remains independent of W C but varies linearly with L C . The breakdown power varies almost linearly with both W C and L C when W C >> L t . We also find that the breakdown power is more susceptible to the variability in the network morphology compared to the breakdown voltage. The analysis offers new insight into the tunable heat dissipation and thermal reliability of CN-TFTs which can be significantly improved through optimization of the network morphology and device geometry.

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Horizontally Aligned Carbon Nanotubes on a Quartz Substrate for Chemical and Biological Sensing

Cited by 46 publications

References 59 publications

Real-time reliable determination of binding kinetics of DNA hybridization using a multi-channel graphene biosensor

Real-time reliable determination of binding kinetics of DNA hybridization using a multi-channel graphene biosensor

RNA Detection Based on Graphene Field-Effect Transistor Biosensor

High field breakdown characteristics of carbon nanotube thin film transistors

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