Hormetic dose-dependent response about typical antibiotics and their mixtures on plasmid conjugative transfer of Escherichia coli and its relationship with toxic effects on growth

A simple judgment method for joint action of antibacterial agents on bacterial resistance

“…Here, bacterial mutation and conjugative transfer (as the main way of horizontal gene transfer) are, respectively used to characterize the emergence and dissemination of ARGs [15] , [16] , [17] . Through obtaining key parameters in the dose-response of antibacterial agents on the mutation frequency and conjugative transfer frequency, the method for judging joint action of antibacterial agents on bacterial resistance was established according to the judgment of joint toxic action.…”