Hormonal changes, semen quality and variance in reproductive activity outcomes of post pubertal rabbits fed Moringa oleifera Lam. leaf powder

Ajuogu, PK; Mgbere, Osaro; Bila, Disere S.; McFarlane, James R.

doi:10.1016/j.jep.2018.12.036

Cited by 35 publications

(32 citation statements)

References 46 publications

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“…In addition, the study on the effect of inositol only revealed histological results of sperm, which is insufficient to verify the effectiveness of the natural product [ 103 ]. Meanwhile, some experiments were conducted on normal cells or animals [ 17 , 40 , 42 , 45 , 76 , 104 , 170 ]. These results are insufficient to support whether the natural products have the capacity to protect genital damage or reverse reproductive disorders.…”

Section: Discussionmentioning

confidence: 99%

“…Luteinizing hormone (LH) and its receptors have been linked with endometriosis-associated infertility. Reproduction is tightly controlled by hypothalamic–pituitary–gonadal axis [ 17 ]. Reproduction systems respond to hormonal signals from the pituitary gland which, in turn, is controlled by hormones produced in the hypothalamus [ 18 ].…”

Section: Infertilitymentioning

confidence: 99%

“…Reproduction systems respond to hormonal signals from the pituitary gland which, in turn, is controlled by hormones produced in the hypothalamus [ 18 ]. Interruption of these processes, in any of the functional events in either sex, leads to fertility impairment [ 17 ] including gonadal dysgenesis, amenorrhea, premature ovarian failure [ 18 ]. Mammalian reproductive physiology is primarily regulated by the gonadotrophins luteinizing hormone (LH) and follicle stimulating hormone (FSH) secreted from the anterior pituitary which act on the gonads to produce sex steroids [ 19 ].…”

Section: Infertilitymentioning

confidence: 99%

“…In female, herbal medicine affects the molecular mechanism and prevents estrogen-dependent endometrial hyperplasia improving ovarian dysfunction, ovarian follicle [ 35 ], and increased endometrial receptivity [ 12 , 15 ]. Additionally, herbal therapy that has actions on the hypothalamic–pituitary–gonadal axis may influence reproductive physiology and ameliorates some infertility problems [ 17 ]. The gonadotrophic-like effects of the extracts were characterized by the following biological parameters: increase in the weight of the ovary and uterus; induction of ovulation; increase in estradiol, progesterone, protein levels; decrease in cholesterol level, and so forth [ 20 ].…”

Section: Plant Extract and Infertilitymentioning

confidence: 99%

“…Moringa oleifera Lam. is a traditional medicine used in Nigeria and is known to have positive effects on sexual behavior and reproductive function [ 17 ]. Leaf powder from this natural compound (5, 10, 15 g/kg for 12 weeks) administered to New Zealand White rabbits elevated semen volume, sperm count, and motility, while it reduced abnormal morphology of sperm.…”

Section: Plant Extract and Infertilitymentioning

confidence: 99%

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Role of Antioxidant Natural Products in Management of Infertility: A Review of Their Medicinal Potential

Noh

Kim

et al. 2020

Antioxidants

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Infertility, a couple’s inability to conceive after one year of unprotected regular intercourse, is an important issue in the world. The use of natural products in the treatment of infertility has been considered as a possible alternative to conventional therapies. The present study aimed to investigate the effects and the mechanisms of various natural products on infertility. We collected articles regarding infertility and natural products using the research databases PubMed and Google Scholar. Several natural products possess antioxidant properties and androgenic activities on productive factors and hormones. Antioxidants are the first defense barrier against free radicals produced by oxidative stress (OS). They remove reactive oxygen stress (ROS), reducing insulin resistance, total cholesterol, fat accumulation, and cancer growth. Moreover, various natural products increase endometrial receptivity and fertility ability showing androgenic activities on productive factors and hormones. For example, Angelica keiskei powder and Astragalus mongholicus extract showed anti-infertility efficacies in males and females, respectively. On the other hand, adverse effects and acute toxicity of natural products were also reported. Tripterygium glycoside decreased fertility ability both in males and females. Results indicate that management of infertility with natural products could be beneficial with further clinical trials to evaluate the safety and effect.

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Section: Discussionmentioning

confidence: 99%

Section: Infertilitymentioning

confidence: 99%

Section: Infertilitymentioning

confidence: 99%

Section: Plant Extract and Infertilitymentioning

confidence: 99%

Section: Plant Extract and Infertilitymentioning

confidence: 99%

See 3 more Smart Citations

Role of Antioxidant Natural Products in Management of Infertility: A Review of Their Medicinal Potential

Noh

Kim

et al. 2020

Antioxidants

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Oxidative Stress in Infertility

Rehman,

Alam,

Amjad

et al. 2024

Biomarkers of Oxidative Stress

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The impact of varying doses of moringa leaf methanolic extract supplementation in the cryopreservation media on sperm quality, oxidants, and antioxidant capacity of frozen-thawed ram sperm

El-Seadawy

Kotp

El‐Maaty

et al. 2022

Trop Anim Health Prod

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To increase rams’ post-thaw semen quality following cryopreservation, this study used enriched Tris-based diluent with varying amounts of moringa leaf methanolic extract (MLME). The antioxidant activity, total phenolic, and total flavonoid content were all assessed in MLME. The sperm of five healthy Awassi rams were collected, divided into 4 equal aliquots, and diluted [1:5; (v/v)] in Tris-citrate-glucose extender supplemented with 0.48, 0.56, and 0.64 mg MLME/ml or without MLME supplementation (control). The percentages of sperm total motility (STM, %), sperm progressive motility (SPM, %) and viability (V, %), abnormal morphology (AM, %), membrane functional integrity (MFI, %), and acrosome integrity (AI %) were measured. Malondialdehyde (MDA), nitric oxide (NO), ascorbic acid (AA), superoxide dismutase (SOD), glutathione peroxidase (GPx), total cholesterol (TC), low-density lipoproteins (LDL), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), zinc (Zn), and copper (Cu) were measured. The total phenolic gallic acid and flavonoid catechin (equivalent) contents were 19.78 mg/g and 11.94 mg/g, respectively. 2,2-Diphenyl-1-picrylhydrazyl (34.37 mM TE/g) and 2,2′-azino-bis/3-ethylbenzothiazoline-6-sulfonic acid (53.47 mM TE/g) were found in MLME. MLME had a 64.59 mM TE/g ferric-reducing power. In comparison to control, the addition of 0.64 mg/ml MLME to Tris-based extender resulted in the highest (P < 0.001) STM (55.22 ± 0.98), SPM (45.41 ± .70), SV (60.01 ± 1.05), MFI (75.23 ± 0.77), and AI (73.13 ± 0.72) and the lowest (P < 0.001) AM (21.34 ± 0.72) values. In comparison to the control, the addition of 0.56 mg/ml semen extender resulted in lower STM, SPM, SV, MFI, and AI with higher AM percentages. MDA (P = 0.03), NO (P = 0.012), CHO (P = 0.0001), and LDL (P = 0.004) were reduced by 0.64 mg/ml MLME, while AA (P = 0.017) and SOD (P = 0.0001) were elevated. In conclusion, the highest copper (P = 0.006) and lowest zinc concentrations in MLME (0.48 mg/ml extender) deteriorated the post-thaw semen quality, prompting us to suggest the addition of 0.64 mg MLME to rams’ Tris-based semen extender.

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Hormonal changes, semen quality and variance in reproductive activity outcomes of post pubertal rabbits fed Moringa oleifera Lam. leaf powder

Cited by 35 publications

References 46 publications

Role of Antioxidant Natural Products in Management of Infertility: A Review of Their Medicinal Potential

Role of Antioxidant Natural Products in Management of Infertility: A Review of Their Medicinal Potential

Oxidative Stress in Infertility

The impact of varying doses of moringa leaf methanolic extract supplementation in the cryopreservation media on sperm quality, oxidants, and antioxidant capacity of frozen-thawed ram sperm

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