Hormonal effects on the secretion and glycoform profile of corticosteroid-binding globulin

Mihrshahi, Robin; Lewis, John G.; Ali, Sinan

doi:10.1016/j.jsbmb.2006.06.031

Cited by 22 publications

(11 citation statements)

References 74 publications

(105 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As hydrocortisone therapy is known to increase free and total plasma cortisol, patients who received hydrocortisone were excluded from the cortisol analyses. However, in vitro, acute glucocorticoid administration does not appear to effect CBG secretion by hepatocytes and in vivo, the binding capacity of cortisol for CBG and total CBG is decreased in patients receiving long term, but not in those receiving acute glucocorticoids; thus, we included patients receiving hydrocortisone in our CBG analyses.…”

Section: Discussionmentioning

confidence: 99%

Depletion of high‐affinity corticosteroid‐binding globulin corresponds to illness severity in sepsis and septic shock; clinical implications

Nenke

Rankin

Chapman

et al. 2015

Clinical Endocrinology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Depletion of high‐affinity corticosteroid‐binding globulin corresponds to illness severity in sepsis and septic shock; clinical implications

Nenke

Rankin

Chapman

et al. 2015

Clinical Endocrinology

View full text Add to dashboard Cite

show abstract

“…52,54 However, as mentioned above, sepsis and acute illness are associated with a decrease in CBG concentration. Furthermore, free serum cortisol assays might underestimate the actual free serum cortisol levels in febrile patients, as measurement is usually [25][26][27] Insulin, IGF-I Decrease Synthesis and/or secretion 120,121 Thyroid hormone Decrease or no effect Synthesis and/or secretion 121,122 Glucocorticoids Decrease Synthesis and/or secretion 123 undertaken at 37 °C and does not take into account the effect of increased body temperature on the binding equilibrium. A temperature-dependent decrease in the affinity of CBG for cortisol leads to further release of bioavailable cortisol, which is not reflected in total serum cortisol measurements.…”

Section: Sepsis and Critical Illnessmentioning

confidence: 99%

Regulation of cortisol bioavailability—effects on hormone measurement and action

2012

View full text Add to dashboard Cite

Routine assessment of the hypothalamic-pituitary-adrenal axis relies on the measurement of total serum cortisol levels. However, most cortisol in serum is bound to corticosteroid-binding globulin (CBG) and albumin, and changes in the structure or circulating levels of binding proteins markedly affect measured total serum cortisol levels. Furthermore, high-affinity binding to CBG is predicted to affect the availability of cortisol for the glucocorticoid receptor. CBG is a substrate for activated neutrophil elastase, which cleaves the binding protein and results in the release of cortisol at sites of inflammation, enhancing its tissue-specific anti-inflammatory effects. Further tissue-specific modulation of cortisol availability is conferred by corticosteroid 11β-dehydrogenase. Direct assessment of tissue levels of bioavailable cortisol is not clinically practicable and measurement of total serum cortisol levels is of limited value in clinical conditions that alter prereceptor glucocorticoid bioavailability. Bioavailable cortisol can, however, be measured indirectly at systemic, extracellular tissue and cell levels, using novel techniques that have provided new insight into the transport, metabolism and biological action of glucocorticoids. A more physiologically informative approach is, therefore, now possible in the assessment of the hypothalamic-pituitary-adrenal axis, which could prove useful in clinical practice.

show abstract

“…Describing parallel changes and differences in gene expression timing in components of the developing eutherian and metatherian nervous systems will highlight the importance of specific gene activities in heterochronic phenomena that lead to taxon-specific neurologic structures and functional capabilities (Smith 2003(Smith , 2006Djavadian et al 2006;Mihrshahi et al 2006); and discovering what gene expression changes correlate with the loss of regeneration capacity of central and peripheral nervous system neurons (e.g., Wintzer et al 2004;Mladinic et al 2005Mladinic et al , 2007Lane et al 2007;Mladinic 2007) could lead to the manipulation of gene expression to activate youthful growth abilities that are normally absent in mature neurons. Some research groups are already applying microarray-based gene-expression-profiling strategies in their investigations of neuroregeneration capacity in the opossum model, but they have had to rely on tools designed for eutherian species (e.g., Lane et al 2007).…”

Section: Genome Research 1209mentioning

confidence: 99%

The opossum genome: Insights and opportunities from an alternative mammal

Samollow¹

2008

Genome Res.

View full text Add to dashboard Cite

The strategic importance of the genome sequence of the gray, short-tailed opossum, Monodelphis domestica, accrues from both the unique phylogenetic position of metatherian (marsupial) mammals and the fundamental biologic characteristics of metatherians that distinguish them from other mammalian species. Metatherian and eutherian (placental) mammals are more closely related to one another than to other vertebrate groups, and owing to this close relationship they share fundamentally similar genetic structures and molecular processes. However, during their long evolutionary separation these alternative mammals have developed distinctive anatomical, physiologic, and genetic features that hold tremendous potential for examining relationships between the molecular structures of mammalian genomes and the functional attributes of their components. Comparative analyses using the opossum genome have already provided a wealth of new evidence regarding the importance of noncoding elements in the evolution of mammalian genomes, the role of transposable elements in driving genomic innovation, and the relationships between recombination rate, nucleotide composition, and the genomic distributions of repetitive elements. The genome sequence is also beginning to enlarge our understanding of the evolution and function of the vertebrate immune system, and it provides an alternative model for investigating mechanisms of genomic imprinting. Equally important, availability of the genome sequence is fostering the development of new research tools for physical and functional genomic analyses of M. domestica that are expanding its versatility as an experimental system for a broad range of research applications in basic biology and biomedically oriented research.Compilation and publication of the genome sequence of the gray short-tailed opossum, Monodelphis domestica, a metatherian (marsupial) mammal (Mikkelsen et al. 2007b), create unique opportunities for investigating the evolutionary processes that have shaped the structural and functional attributes of mammalian and other vertebrate genomes. These opportunities arise from both the unique phylogenetic position of metatherians in the vertebrate scheme and some fundamental characteristics of metatherians that distinguish them from other mammalian species.Modern mammals comprise three major lineages (Fig. 1). Judged from multiple nuclear sequence and mtDNA alignments, the most closely related of these, the Metatheria and Eutheria (placental mammals), diverged from their most recent common ancestor ∼173-190 million years ago (Mya) (Kumar and Hedges 1998;Woodburne et al. 2003;van Rheede et al. 2006). The other major clade, the Prototheria, of which the egg-laying monotremes (platypus and four species of echidnas) are the only living representatives, branched off 20-35 million years (Myr) prior to the metatherian-eutherian divergence (Phillips and Penny 2003;Woodburne et al. 2003;van Rheede et al. 2006). 2 By way of reference, the separation of mammals and birds occurred at least 310 Mya (d...

show abstract

Hormonal effects on the secretion and glycoform profile of corticosteroid-binding globulin

Cited by 22 publications

References 74 publications

Depletion of high‐affinity corticosteroid‐binding globulin corresponds to illness severity in sepsis and septic shock; clinical implications

Depletion of high‐affinity corticosteroid‐binding globulin corresponds to illness severity in sepsis and septic shock; clinical implications

Regulation of cortisol bioavailability—effects on hormone measurement and action

The opossum genome: Insights and opportunities from an alternative mammal

Contact Info

Product

Resources

About