Hormonal Responses to Short Term Fasting in Postmenopausal Women*

Beitins, Inese Z.; Barkan, Ariel L.; Klibanski, Anne; Kyung, Nan Ho; Reppert, S. M.; Badger, Thomas M.; Veldhuis, Johannes D.; McArthur, Janet W.

doi:10.1210/jcem-60-6-1120

Cited by 51 publications

(18 citation statements)

References 33 publications

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“…In fasting rats, the pineal levels of melatonin were found to be lower than in control animals but, unex pectedly, plasma levels were found to be high er [23]. A similar increase in melatonin levels in the peripheral blood of fasting subjects was reported in other studies as well [24,25]. This discrepancy was recently elucidated by the detection of a substantial elevation of GIT melatonin levels in fasting mice [26], It was hypothesized that in fasting animals some of the GIT melatonin may escape into the pe ripheral circulation via the portal vein [26].…”

Section: Serumsupporting

confidence: 86%

Pinealectomy Reduces Melatonin Levels in the Serum but Not in the Gastrointestinal Tract of Rats

Bubenik

Brown²

1997

Neurosignals

101

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Melatonin levels were determined in serum and gastrointestinal tract (GIT) tissues of control (C), sham-pinelaectomized (SPx) and pinealectomized (Px) rats sacrificed in mid scoto-phase. Serum melatonin concentrations of Px rats exhibited the significantly lowest values (8.6 pg/ml), followed by SPx (20.1 pg/ml) and C (37.5 pg/ml) rats. In C, the ileum (542 pg/ ml) and jejunum (531 pg/ml) exhibited the highest average GIT concentrations, followed by the colon (362 pg/ml), stomach (359 pg/ml) and cecum (164 pg/ml). However, only jejunum and ileum samples had significantly higher melatonin levels than cecum samples. There were no major differences between GIT melatonin levels in Px and C rats (range: 169–247 pg/ml). Statistically, pinealectomy did not influence melatonin levels in the GIT of rats. The findings support the hypothesis that melatonin concentrations in the tissues of the GIT are independent of pineal production.

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Section: Serumsupporting

confidence: 86%

Pinealectomy Reduces Melatonin Levels in the Serum but Not in the Gastrointestinal Tract of Rats

Bubenik

Brown²

1997

Neurosignals

101

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“…ACTH. cor tisol and AD is enhanced [171,172], The hypercortisolism demonstrated in patients with functional amenorrhea is consistent with the postulated role ofstress in this disor der. However, few studies dealing with plasma neuro transmitters are reported in the literature.…”

Section: Functional Amenorrhea and Postmenopausal Womensupporting

confidence: 72%

Plasma Neurotransmitters and Functional Illness (Part 3 of 3)

Lechín¹,

Dijs²,

Lechin

1996

Psychother Psychosom

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Although the concept of functional illness has blurred boundaries, some consensus exists on its understanding among clinicians. In short, it is easier to conceive than to define functional illness. Semantic and conceptual discussion concerning this issue have been endless. Many links exist that connect brain and body (mind and organs, psyche and soma). Amongst them, neurotransmitters, released by peripheral neurons and some glandular cells (adrenal, enterochromaffm cells, mast cells), are diverted into the bloodstream. Although neurotransmitters cannot cross the blood-brain barrier, basic and clinical research has progressively established the relationship between central and peripheral neurochemical activities. Hence, it is possible to obtain some approach to the central profile through the measurement of circulating neurotransmitters. However, this approach is more reliable if we can measure all circulating factors and, in addition, test the responses to different kinds of challenges (stressors, drugs, etc.). All diseases (somatic, psychiatric and psychosomatic) present some kind of plasma neurotransmitter disturbance; however, only in some has the whole abnormal profile been established. Technical difficulties as well as expensive procedures have interfered with the generalization of this research area. In the present review article, we summarize data quoted from current scientific literature reporting exhaustive research in this area.

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“…Short-term fasting in healthy men decreased (Rojdmark and Wetterberg 1989) postmenopausal women increased endogenous MEL concentration in the serum (Breitins et al 1985). In women 72-h fasting resulted in a MEL secretion phase-shift (Berga et al 2001).…”

Section: Discussionmentioning

confidence: 93%

Metabolic Effects of Prolonged Melatonin Administration and Short-Term Fasting in Laboratory Rats

Bojková

Marková²,

Ahlersová

et al. 2006

Acta Vet. Brno

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Bojková B., M. Marková, E. Ahlersová, I. Ahlers, E. Adámeková, P. Kubatka, M. Kassayová: Metabolic Effects of Prolonged Melatonin Administration and Short-Term Fasting in Laboratory Rats. Acta Vet. Brno 2006, 75: 21-32.The aim of this work was to evaluate the effect of prolonged administration of the pineal hormone melatonin and short-term fasting on metabolic variables in male and female Wistar:Han rats. Melatonin (MEL, 4µg/ml of tap water) was administered daily since the 5 th week of age. The control group drank tap water. Rats were fed a standard type of diet ad libitum and were kept in the light regimen L:D -12:12 h. The experiment was terminated after 11 (variant B) or 12 (variant A) weeks of MEL administration. The animals were sacrificed by quick decapitation following overnight fasting (variant A) or 48-h fasting (variant B). Selected organs and tissues were removed and weighed and selected metabolic variables in the serum and tissues were determined.MEL decreased body mass independent of food and water intake in both sexes. In males (variant A) MEL increased the weight of the heart muscle, spleen and adrenals; it decreased the absolute weight of epididymal fat and increased serum corticosterone and phospholipids concentration in comparison with controls. In females, serum glucose decrease and liver triacylglycerols increase were found. After 48-h fasting (variant B) liver, spleen and adrenal weight increase in MELdrinking females was found. In males MEL increased the thymus weight and decreased the epididymal fat weight. In both sexes MEL increased serum corticosterone and liver glycogen concentration; MEL increased serum glucose in males and serum cholesterol concentration in females. Changes in the evaluated variables were also related to fasting duration prior to decapitation.A 48-h fasting at the end of the prolonged MEL intake (variant B vs. A) decreased the absolute liver weight in both sexes and the epididymal/periovarial fat weight, and increased thymus weight in males. In females it decreased the absolute heart muscle weight and increased the spleen weight. In males, 48-h fasting increased serum corticosterone and phospholipids concentration; it decreased the liver triacylglycerols content in females and the liver cholesterol content in males and females. In both sexes 48-h fasting increased glucose concentration in the serum and glycogen concentration in the liver and heart muscle as well as triacylglycerols and cholesterol concentration in the serum, phospholipids concentration in the liver and bone marrow and decreased malondialdehyde concentration in the liver. Forty-eight hour fasting after prolonged MEL administration resulted in a wider range of carbohydrate and lipid metabolism alterations of young rats of both sexes. Melatonin, prolonged administration, metabolic variables, short-term fastingMelatonin (MEL), the main pineal hormone, is a substance of numerous physiological effects. In addition to epiphysis, MEL is synthesized in other tissues too -e.g. in the retina, extraorbi...

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Hormonal Responses to Short Term Fasting in Postmenopausal Women*

Cited by 51 publications

References 33 publications

Pinealectomy Reduces Melatonin Levels in the Serum but Not in the Gastrointestinal Tract of Rats

Pinealectomy Reduces Melatonin Levels in the Serum but Not in the Gastrointestinal Tract of Rats

Plasma Neurotransmitters and Functional Illness (Part 3 of 3)

Metabolic Effects of Prolonged Melatonin Administration and Short-Term Fasting in Laboratory Rats

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