Hormone receptor expression, clinical and histopathological analysis in feline injection site sarcomas

Zanuncio, Virgínia Vinha; Conceição, Lissandro Gonçalves; Loures, Fabrícia Hallack; Cassali, Geovanni Dantas; Rocha, Kelvin Oliveira; Lima, Bruna Mendes

doi:10.1111/vco.12666

Cited by 2 publications

(1 citation statement)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Activation of the Janus kinase-signal transducer and activator of transcription 3 (STAT3) also might play an important role in the tumorigenesis of FISS [ 78 ]. Interestingly, it was shown via immunohistochemistry that the expression of estrogen receptors in FISSs, but not the expression of progesterone receptors, correlated with clinical and histopathological aspects (mitotic index and degree of pleomorphism) and thus, estrogen receptors expression could influence tumor growth [ 79 ].…”

Section: Feline Injection-site Sarcoma (Fiss)mentioning

confidence: 99%

Feline Injection-Site Sarcoma and Other Adverse Reactions to Vaccination in Cats

Hartmann¹,

Egberink

Möstl

et al. 2023

Viruses

View full text Add to dashboard Cite

Vaccine-associated adverse events (VAAEs), including feline injection-site sarcomas (FISSs), occur only rarely but can be severe. Understanding potential VAAEs is an important part of informed owner consent for vaccination. In this review, the European Advisory Board on Cat Diseases (ABCD), a scientifically independent board of feline medicine experts, presents the current knowledge on VAAEs in cats, summarizing the literature and filling the gaps where scientific studies are missing with expert opinion to assist veterinarians in adopting the best vaccination practice. VAAEs are caused by an aberrant innate or adaptive immune reaction, excessive local reactions at the inoculation site, an error in administration, or failure in the manufacturing process. FISS, the most severe VAAE, can develop after vaccinations or injection of other substances. Although the most widely accepted hypothesis is that chronic inflammation triggers malignant transformation, the pathogenesis of FISS is not yet fully understood. No injectable vaccine is risk-free, and therefore, vaccination should be performed as often as necessary, but as infrequently as possible. Vaccines should be brought to room temperature prior to administration and injected at sites in which FISS surgery would likely be curative; the interscapular region should be avoided. Post-vaccinal monitoring is essential.

show abstract

Section: Feline Injection-site Sarcoma (Fiss)mentioning

confidence: 99%