Hormone refractory carcinoma prostate with peritoneal metastases and malignant ascites without skeletal involvement: A case report and review of literature

Abstract

Peritoneal carcinomatosis is rare in prostate cancer especially in the absence of skeletal or other visceral metastases. We report a case of hormone refractory adenocarcinoma prostate presenting with only peritoneal metastases and massive malignant ascites. Palliation with docetaxel based cytotoxic chemotherapy resulted in clinical improvement of refractory ascites decreasing respiratory embarrassment and thereby improving the quality of life.

An unusual presentation of a patient with advanced prostate cancer, massive ascites and peritoneal metastasis: Case report and literature review

“…Skin, optic nerve, mandible, testicles, penis, pituitary gland, thyroid, salivary glands are some of the uncommon sites reported in the literature. The omentum as metastatic site is extremely rare, with only 15 cases presented until now [6–21] ( Table 1 ). The age of these patients at diagnosis ranged between 29 and 76 years, the majority of them had a high risk localized adenocarcinoma at diagnosis and only three presented with bone metastases.…”

“…The age of these patients at diagnosis ranged between 29 and 76 years, the majority of them had a high risk localized adenocarcinoma at diagnosis and only three presented with bone metastases. The time gap between diagnosis and ascites was from 1 to 16 years [6–21] . Ascites responded in 7 out of 16 cases, 4 to endocrine manipulations and 3 to chemotherapy.…”

Castrate-Resistant Prostate Cancer with Peritoneal Metastases Treated with Docetaxel-Based Chemotherapy

“…To the best of our knowledge, this is the largest series described to date since only 10 cases have been previously reported as isolated case reports [8,9,10,11,12,13,14,15,16,17] (table 1). …”

“…Other rare metastatic sites also described include the skin, central nervous system, eyes, parotid glands, testis, adrenal glands and the penis [4,5,6,7]. To our knowledge, prostate cancer with peritoneal metastases is an extremely rare entity with only 10 isolated cases reported in the literature [8,9,10,11,12,13,14,15,16,17] (table 1). …”

Metastatic prostate cancer with malignant ascites: A case report and literature review

“…There are only 15 published cases (Table 1). [2][3][4][5][6][7][8][9][10][11][12][13][14][15] We report a case of malignant ascites from advanced metastatic prostate cancer with high volume disease in an African American male.…”