Hormone replacement therapy and intraocular pressure

Sator, Michael; Joura, Elmar A.; Frigo, Peter; Kurz, Christine; Metka, M.; Hommer, Anton; Huber, Johannes

doi:10.1016/s0378-5122(97)00060-1

Cited by 64 publications

(49 citation statements)

References 7 publications

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“…These findings were similar to those found by Sator et al [28]. It has been reported that the IOP of a 56-year-old woman with primary open-angle glaucoma had decreased after 4 weeks of HRT [62].…”

Section: Discussionsupporting

confidence: 91%

“…Estrogen causes an increase in endothelium-based constitutive NOS. NO and estrogen have been shown to play a critical role in the control of IOP by altering secretion and outflow of aqueous [28]. …”

Section: Discussionmentioning

confidence: 99%

“…In addition, elderly females on HRT have shown reduced prevalence of nuclear cataract [26, 27], glaucoma [28]and age-related macular degeneration [29]. There is preliminary evidence that early menopause may be associated with increased risk for several major ocular diseases, including glaucoma, which may be linked to ocular ischemia [30, 31].…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Menopause and Hormone Replacement Therapy on Quality and Quantity of Tear, Intraocular Pressure and Ocular Blood Flow

et al. 2004

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Objective: To evaluate the effects of menopause and hormone replacement therapy (HRT) on the quality and amount of tear, intraocular pressure (IOP) and retrobulbar blood flow velocities. Patients and Methods: Twenty women aged between 40 and 50 years, free of ocular and systemic diseases and planning to receive HRT were recruited as the study group. Twenty-four healthy, age-matched but still menstruating women were enrolled as controls. On the first day of study basal and reflex Schirmer test, tear break-up time and IOP measurements (at 08.00, 12.00 and 16.00 h) were performed for all groups. On the second day of the study, the peak systolic velocity (PSV), end diastolic velocity (EDV) and resistivity index (RI) of the ophthalmic (OA), central retinal (CRA), nasal (NSPCA) and temporal short posterior ciliary (TSPCA) arteries were determined by color Doppler imaging. The menopausal group received HRT for 2 months, when all measurements were repeated for the 15 women who had received HRT on a daily basis. Results: The quality and amount of tear decreased (p < 0.01), IOP (p < 0.01) and RI of the CRA, TPCA and NPCA (p < 0.05) increased in postmenopausal women compared with the control group. After 2 months of HRT, the quality and amount of tear had increased (p < 0.001) and the IOP had decreased (p < 0.001). The PSV of the CRA and TSPCA had decreased (p < 0.05), as had the RI in the CRA (p < 0.001), NSPCA and TSPCA (p < 0.05). Conclusion: We conclude that age-induced changes on quality and amount of tear, IOP and retrobulbar blood flow are intensified by the menopause and that it may be possible to decrease the menopausal effects on these parameters by HRT.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Effects of Menopause and Hormone Replacement Therapy on Quality and Quantity of Tear, Intraocular Pressure and Ocular Blood Flow

et al. 2004

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“…In postmenopausal women, hormonal therapy (HT) significantly lowered IOP. [14,15] In the Rotterdam study, early menopause was associated with a higher prevalence of glaucoma. [16] Primary open-angle glaucoma (POAG) has shown differences in its frequency of occurrence between genders, but results are again inconsistent.…”

Section: Introductionmentioning

confidence: 99%

Ocular perfusion pressure variation in relation to gender and body mass index in healthy young adults

Ramya¹,

Ramashetty²,

Nataraj³

2018

Natl J Physiol Pharm Pharmacol

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Background: Overweight and obesity are defined as abnormal or excessive fat accumulation that may impair health. Body mass index (BMI) is a simple index of weight-for-height that is commonly used to classify overweight and obesity in adults. The good irrigation of the ocular tissues is ensured by an adequate ocular perfusion pressure (OPP) which depends on a complex regulatory process that balances blood pressure (BP) and the intraocular pressure (IOP). Aims and Objectives: The aim of this study is to study the role of gender and BMI on OPP in healthy young adults. Materials and Methods: A total of 100 healthy young adult volunteers comprising 50 obese (25 males and 25 females) and 50 non-obese (25 males and 25 females) in the age group of 18-19 years were selected among MBBS Phase I students of JSS Medical College, JSSU, Mysuru. BP and IOP were recorded using standard methods. Mean arterial pressure (MAP) and OPP were calculated. Results: Systolic BP (P < 0.001), MAP (P < 0.001), IOP (P < 0.05), and OPP (P < 0.05) were higher in obese group when compared with non-obese group. MAP and OPP were significantly higher in obese males when compared with obese females (P < 0.001). Similarly, significantly higher MAP and OPP were observed in non-obese males when compared with non-obese females (P < 0.05). Conclusion: The MAP, IOP, and OPP were significantly higher in obese group. There exists a significant gender difference in MAP and OPP, which were significantly higher in males.

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“…Hormone replacement therapy significantly lowers intraocular pressure, suggesting a role for estrogen in the control of intraocular pressure [15,16].…”

Section: Introductionmentioning

confidence: 99%

Expression of estrogen receptor α and 17β-hydroxysteroid dehydrogenase 4 in the ciliary body

Kobayashi

Iwakiri

Kobayashi

et al. 2003

Graefe's Arch Clin Exp Ophthalmol

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Hormone replacement therapy and intraocular pressure

Cited by 64 publications

References 7 publications

The Effects of Menopause and Hormone Replacement Therapy on Quality and Quantity of Tear, Intraocular Pressure and Ocular Blood Flow

The Effects of Menopause and Hormone Replacement Therapy on Quality and Quantity of Tear, Intraocular Pressure and Ocular Blood Flow

Ocular perfusion pressure variation in relation to gender and body mass index in healthy young adults

Expression of estrogen receptor α and 17β-hydroxysteroid dehydrogenase 4 in the ciliary body

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