Hormone replacement therapy and some salivary antimicrobial factors in post- and perimenopausal women

Leimola‐Virtanen, Riitta; Helenius, Hans; Laine, Merja

doi:10.1016/s0378-5122(97)00024-8

Cited by 46 publications

(38 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous studies have shown that secretion of proteins and the inorganic components of saliva is hormone-related (Tenovuo et al 1981, Gómez et al 1993, Salvolini et al 1998, Laine & Pienihäkkinen 2000 and HRT appears to increase saliva flow rate, buffer effect and protein content of saliva in menopausal women (Laine & Leimola-Virtanen 1996, Leimola-Virtanen et al 1997, Eliasson et al 2003. In our present study, we identified ER in both mucous and serous acinar and ductal cells in minor salivary glands, and in parotid and submandibular glands.…”

Section: Discussionsupporting

confidence: 68%

“…Oral dryness can lead to considerable difficulty in speaking, eating and tasting, and predispose mucosa to wounds, abrasion and infection. A number of studies have shown that hormone replacement therapy (HRT) can relieve this oral discomfort in postmenopausal women, further suggesting a role for female sex hormones in the maintenance of oral tissues (Wardrop et al 1989, Forabosco et al 1992, Leimola-Virtanen et al 1997, Eliasson et al 2003.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Estrogen receptor-beta is the predominant estrogen receptor subtype in human oral epithelium and salivary glands

Välimaa

Savolainen

Soukka

et al. 2004

Journal of Endocrinology

181

149

View full text Add to dashboard Cite

Many studies have shown that the oral mucosa and salivary glands are sensitive to estrogen action. However, the expression of estrogen receptors (ERs) within these tissues is an area of controversy. ERs exist as two subtypes (ER and ER ), and we hypothesized that the incongruity between ER expression and estrogen sensitivity may result from differential expression of ER subtypes in oral tissues. To test this hypothesis, we analyzed oral mucosal and salivary gland samples for ER and ER protein expression by immunohistochemistry from a cross-section of patients attending hospital for surgical problems of the head and neck. ER was not detected in oral buccal and gingival epithelium or in salivary glands. In contrast, ER was widely expressed at high levels in all oral tissues studied. Within these tissues, ER was observed primarily in keratinocytes and salivary gland acinar and ductal cells. Our results demonstrating the expression of only the ER subtype within oral tissues may explain the contradictory results from previous studies investigating ER expression in these tissues. Importantly, these results suggest that estrogens may act via ER in oral tissues and explain the effect of hormonal changes on the oral mucosa as well as on saliva secretion and composition.

show abstract

Section: Discussionsupporting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Estrogen receptor-beta is the predominant estrogen receptor subtype in human oral epithelium and salivary glands

Välimaa

Savolainen

Soukka

et al. 2004

Journal of Endocrinology

181

149

View full text Add to dashboard Cite

show abstract

“…The determination of the level of antigens and antibodies can be beneficial in patients with the diagnosed oral candidiasis, who are resistant to antimycotic treatment. In the literature, conflicting results of the studies on anti-Candida antibody levels in patients with symptoms of candidiasis can be found [19,20]. Our study showed that in a selected group of HRT-taking patients with the positive mycological tests, positive results of serum antinuclear IgG antibodies titres were obtained in all of them.…”

Section: Discussionmentioning

confidence: 52%

“…The determination of IgM antibody titres revealed positive results in 70% of persons in the study group and in 50% of controls. The study carried out by Leimola-Virtanen et al [20] has indicated the decreased level of IgA, sigA and IgG antibodies and the increased level of IgM antibodies in HRT-taking menopausal women. They analysed the levels of peroxidase, IgG, IgM and IgA in saliva before and after menopause in HRT-taking women.…”

Section: Discussionmentioning

confidence: 95%

Experimental immunology Effect of hormone replacement therapy on the incidence and extent of Candida -associated denture stomatitis

Mierzwińska-Nastalska¹,

Golecka-Bąkowska²,

Bychawska³

et al. 2013

cejoi

View full text Add to dashboard Cite

show abstract

“…It also appears that OD severity correlates with serum 17β-estradiol concentration. It has been shown that the composition of saliva in menopausal women is estrogen dependent [17]. In addition, hormonal replacement therapy has been reported to reduce the complaints of dry mouth feeling resulting in improved oral wellbeing.…”

Section: Figurementioning

confidence: 99%

Serum 17β-estradiol and oral dryness feeling in menopause

Agha‐Hosseini¹,

Mirzaii‐Dizgah²

2011

Health

View full text Add to dashboard Cite

The aim of this study was to compare serum 17β-estradiol of menopausal women with/without Oral Dryness (OD) feeling, and evaluate the relationship between serum 17β-estradiol and severity of OD feeling. A case-control study was carried out on 70 selected menopausal women aged 40 -77 years with or without OD feeling (35 as case, 35 as control) conducted at the Clinic of Oral Medicine, Tehran University of Medical Sciences. Xerostomia inventory (XI) score was used as an index of OD feeling severity. The serum 17β-estradiol concentration was measured by an enzyme immunoassay kit (ELISA). Statistical analysis of Student's t-test and Spearman correlation coefficient was used. The mean serum concentration of 17β-estradiol was significantly lower in case than control. There was a significant negative correlation between XI score and concentration of 17β-estradiol in menopausal women (r = -0.311, P = 0.004). It seems that there is a negatively slight correlation between OD feeling severity and serum 17β-estradiol in menopausal women.

show abstract

Hormone replacement therapy and some salivary antimicrobial factors in post- and perimenopausal women

Cited by 46 publications

References 20 publications

Estrogen receptor-beta is the predominant estrogen receptor subtype in human oral epithelium and salivary glands

Estrogen receptor-beta is the predominant estrogen receptor subtype in human oral epithelium and salivary glands

Experimental immunology Effect of hormone replacement therapy on the incidence and extent of Candida -associated denture stomatitis

Serum 17β-estradiol and oral dryness feeling in menopause

Contact Info

Product

Resources

About