PurposeDeveloped countries control pandemics using smart decisions and processes based on medical standards and modern technologies. Studies on risk-reduction and humantechnology interaction are scarce. This study developed a model to examine the relationship between citizens, pandemic-related technology and official safety practices.Design/methodology/approachThis study investigated the mediating role of new health regulations and moderating role of safety incentives due to COVID-19 case reduction in pandemic severity control. This study included 407 operations managers, nursing staff conducting pandemic testing and reporting, doctors and security personnel in China. An artificial neural network (ANN) was used to check nonlinear regressions and model predictability.FindingsThe results demonstrated the impact of the introduction of new technology protocols on the implementation of new health regulations and aided pandemic severity control. The safety incentive of case reductions moderated the relationship between new health regulations and pandemic severity control. New health regulations mediated the relationship between the introduction of new technology protocols and pandemic severity control.Research limitations/implicationsFurther research should be conducted on pandemic severity in diversely populated cities, particularly those that require safety measures and controls. Future studies should focus on cloud computing for nurses, busy campuses and communal living spaces.Social implicationsAuthorities should involve citizens in pandemic-related technical advances to reduce local viral transmission and infection. New health regulations improved people's interactions with new technological protocols and understanding of pandemic severity. Pandemic management authorities should work with medical and security employees.Originality/valueThis study is the first to demonstrate that a safety framework with technology-oriented techniques could reduce future pandemics using managerial initiatives.