Host B chromosomes as potential sex ratio distorters of intestinal nematode infrapopulations in the yellow-necked mouse (Apodemus flavicollis)

Jovanović, Vladimir; Čabrilo, Borislav; Budinski, İvana; Čabrilo, Olivera Bjelić; Adnađević, Tanja; Blagojević, Jelena; Vujošević, Mladen

doi:10.1017/s0022149x18000548

Cited by 3 publications

(5 citation statements)

References 59 publications

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“…Bjelić-Čabrilo et al [ 35 ] conducted extensive research by describing helminth fauna’s quantitative and qualitative composition in a sample of 588 bank voles. Extensive parasitological studies of the yellow-necked and wood mouse were also carried out [ 36 , 37 , 38 , 39 ]. Furthermore, studies of the intestinal nematode community’s interaction with immune response and gene expression were conducted on the yellow-necked mouse [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

Host–Parasite Relationship—Nematode Communities in Populations of Small Mammals

Miljević

Čabrilo

Budinski

et al. 2022

Animals

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Nematode burdens and variation in morphological characteristics were assessed in eighty-eight animals from three host species (Apodemus sylvaticus, Apodemus flavicollis, and Myodes glareolus) from eight localities in Serbia. In total, 15 species of nematodes were identified, and the overall mean parasite species richness (IndPSR) was 1.61 per animal (1.98 in A. flavicollis, 1.43 in M. glareolus, and 0.83 in A. sylvaticus). Furthermore, the studied host species significantly differed in individual parasite load (IndPL) and in the following morphological characters: spleen mass, body condition index (BCI), and body mass. We aimed to analyze the relationship between the burden of intestinal nematodes, on one hand, and the body conditions of the host and its capability to develop immune defends on the other. Spleen mass was considered as a measure of immune response. In all host species, larger animals with a better condition (higher BCI) were infected with more parasites species (IndPSR), while parasite load was not related to BCI. Only in A. flavicollis were males significantly larger, but females of the same sizes were infected with more parasite species. This female-biased parasitism is contrary to the theoretical expectation that males should be more parasitized, being larger, more active, with a wider home range. Although the spleen size was significantly correlated with body condition and body mass, IndPSR was not related to spleen mass in any studied species, but in M. galareolus, we found that a smaller spleen was related to higher infection intensity (IndPL).

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Section: Introductionmentioning

confidence: 99%

Host–Parasite Relationship—Nematode Communities in Populations of Small Mammals

Miljević

Čabrilo

Budinski

et al. 2022

Animals

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“…In an earlier study concerning sex ratio variation of intestinal nematode infrapopulations in A. flavicollis , Jovanović et al [ 66 ] distinguished three age categories of host mice, estimated from dry eye lens weight. Based on the same criterion, we also recognized the same three age categories of adult A. flavicollis , i.e.…”

Section: Methodsmentioning

confidence: 99%

“… A1—first age category (animals with dry eye lens mass ≤ 15 mg), A2—second age category (animals with 15–25 mg of dry eye lens mass), A3—third age category (animals with dry eye lens mass > 25 mg) according to Jovanović et al yyyy[ 66 ]; P0—non-parasitized animals, P1—animals parasitized by one nematode species, P2—animals parasitized by two nematode species, P3—animals parasitized by three to five nematode species. m—males, f—females; B0—animals with standard karyotype (without B chromosomes, Bs), B + – animals with Bs …”

Section: Methodsmentioning

confidence: 99%

“…The yellow-necked mouse ( Apodemus flavicollis Melchior, 1834), common in the Western Palearctic region, is abundantly distributed throughout the territory of Serbia. The nematode fauna of A. flavicollis is well documented in several European countries [ 59 – 62 ], as well as in Serbia [ 63 – 66 ]. Additionally, this mouse species is characterized by the presence of the oldest known chromosome polymorphism [ 67 ], i.e.…”

Section: Introductionmentioning

confidence: 99%

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Canalization and developmental stability of the yellow-necked mouse (Apodemus flavicollis) mandible and cranium related to age and nematode parasitism

Jojić

Čabrilo

et al. 2021

Front Zool

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Background Mammalian mandible and cranium are well-established model systems for studying canalization and developmental stability (DS) as two elements of developmental homeostasis. Nematode infections are usually acquired in early life and increase in intensity with age, while canalization and DS of rodent skulls could vary through late postnatal ontogeny. We aimed to estimate magnitudes and describe patterns of mandibular and cranial canalization and DS related to age and parasite intensity (diversity) in adult yellow-necked mice (Apodemus flavicollis). Results We found the absence of age-related changes in the levels of canalization for mandibular and cranial size and DS for mandibular size. However, individual measures of mandibular and cranial shape variance increased, while individual measures of mandibular shape fluctuating asymmetry (FA) decreased with age. We detected mandibular and cranial shape changes during postnatal ontogeny, but revealed no age-related dynamics of their covariance structure among and within individuals. Categories regarding parasitism differed in the level of canalization for cranial size and the level of DS for cranial shape. We observed differences in age-related dynamics of the level of canalization between non-parasitized and parasitized animals, as well as between yellow-necked mice parasitized by different number of nematode species. Likewise, individual measures of mandibular and cranial shape FA decreased with age for the mandible in the less parasitized category and increased for the cranium in the most parasitized category. Conclusions Our age-related results partly agree with previous findings. However, no rodent study so far has explored age-related changes in the magnitude of FA for mandibular size or mandibular and cranial FA covariance structure. This is the first study dealing with the nematode parasitism-related canalization and DS in rodents. We showed that nematode parasitism does not affect mandibular and cranial shape variation and covariance structure among and within individuals. However, parasite intensity (diversity) is related to ontogenetic dynamics of the levels of canalization and DS. Overall, additional studies on animals from natural populations are required before drawing some general conclusions.

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“…Although the influence of host genetic background on parasite infection has already been well established, this is the first study in mammals that correlates presence of Bs with immune response. Curiously enough, the presence of Bs in this species plays an important role in infrapopulations of their certain endoparasites by shifting sex balance to higher proportion of males [ 223 ].…”

Section: The Effects Of B-chromosomesmentioning

confidence: 99%

B Chromosomes in Populations of Mammals Revisited

Vujošević

Rajičić

Blagojević

2018

Genes

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The study of B chromosomes (Bs) started more than a century ago, while their presence in mammals dates since 1965. As the past two decades have seen huge progress in application of molecular techniques, we decided to throw a glance on new data on Bs in mammals and to review them. We listed 85 mammals with Bs that make 1.94% of karyotypically studied species. Contrary to general view, a typical B chromosome in mammals appears both as sub- or metacentric that is the same size as small chromosomes of standard complement. Both karyotypically stable and unstable species possess Bs. The presence of Bs in certain species influences the cell division, the degree of recombination, the development, a number of quantitative characteristics, the host-parasite interactions and their behaviour. There is at least some data on molecular structure of Bs recorded in nearly a quarter of species. Nevertheless, a more detailed molecular composition of Bs presently known for six mammalian species, confirms the presence of protein coding genes, and the transcriptional activity for some of them. Therefore, the idea that Bs are inert is outdated, but the role of Bs is yet to be determined. The maintenance of Bs is obviously not the same for all species, so the current models must be adapted while bearing in mind that Bs are not inactive as it was once thought.

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Host B chromosomes as potential sex ratio distorters of intestinal nematode infrapopulations in the yellow-necked mouse (Apodemus flavicollis)

Cited by 3 publications

References 59 publications

Host–Parasite Relationship—Nematode Communities in Populations of Small Mammals

Host–Parasite Relationship—Nematode Communities in Populations of Small Mammals

Canalization and developmental stability of the yellow-necked mouse (Apodemus flavicollis) mandible and cranium related to age and nematode parasitism

B Chromosomes in Populations of Mammals Revisited

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