Host-based processes as therapeutic targets for Rift Valley fever virus

Pinkham, Chelsea; Ahmed, Aslaa; Bracci, Nicole; Narayanan, Aarthi; Kehn-Hall, Kylene

doi:10.1016/j.antiviral.2018.10.004

Cited by 5 publications

(4 citation statements)

References 153 publications

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“…In the context of RVF-induced developmental anomalies, a recent publication, which presented transcriptomic data of the human host response following RVFV infection, demonstrated downregulation of the host gene for miR-17-92 [ 26 ]. The miR-17–92 family collectively encodes a total of 15 miRNAs that are essential for the development of vertebrates, and deregulation is involved in the pathogenesis of a variety of human diseases, especially congenital developmental disorders [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

In silico identification of novel pre-microRNA genes in Rift valley fever virus suggest new pathomechanisms for embryo-fetal dysgenesis

Sadeghi,

Groschup,

Eiden

2024

Virulence

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MicroRNAs (miRNAs) are small non-coding RNAs that regulate the post-transcriptional expression of target genes. Virus-encoded miRNAs play an important role in the replication of viruses, modulate gene expression in both the virus and host, and affect their persistence and immune evasion in hosts. This renders viral miRNAs as potential targets for therapeutic applications, especially against pathogenic viruses that infect humans and animals. Rift Valley fever virus (RVFV) is a mosquito-borne zoonotic RNA virus that causes severe disease in both humans and livestock. High mortality among newborn lambs and abortion storms are key characteristics of an RVF outbreak. To date, limited information is available on RVFV-derived miRNAs. In this study, computational methods were used to analyse the RVFV genome for putative pre-miRNA genes, which were then analysed for the presence of mature miRNAs. We detected 19 RVFV-encoded miRNAs and identified their potential mRNAs targets in sheep ( Ovis aries) , the most susceptible host. The identification of significantly enriched O. aries genes in association with RVFV miRNAs will help elucidate the molecular mechanisms underlying RVFV pathogenesis and potentially uncover novel drug targets for RVFV.

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Section: Discussionmentioning

confidence: 99%

In silico identification of novel pre-microRNA genes in Rift valley fever virus suggest new pathomechanisms for embryo-fetal dysgenesis

Sadeghi,

Groschup,

Eiden

2024

Virulence

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“…Rift Valley Fever virus (RVFV) is an enveloped, segmented, negative-sense RNA virus that replicates in the cytoplasm of host cells [ 79 ]. Its genome consists of L, M, and S segments, and it is primarily transmitted by mosquitoes.…”

Section: Role Of Exosomes and Autophagy Crosstalk In Enveloped Virus ...mentioning

confidence: 99%

Exosome–Autophagy Crosstalk in Enveloped Virus Infection

Wang

Ren

Bai

et al. 2023

IJMS

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Exosomes, which are extracellular vesicles (EVs) predominantly present in bodily fluids, participate in various physiological processes. Autophagy, an intracellular degradation mechanism, eliminates proteins and damaged organelles by forming double-membrane autophagosomes. These autophagosomes subsequently merge with lysosomes for target degradation. The interaction between autophagy and endosomal/exosomal pathways can occur at different stages, exerting significant influences on normal physiology and human diseases. The interplay between exosomes and the autophagy pathway is intricate. Exosomes exhibit a cytoprotective role by inducing intracellular autophagy, while autophagy modulates the biogenesis and degradation of exosomes. Research indicates that exosomes and autophagy contribute to the infection process of numerous enveloped viruses. Enveloped viruses, comprising viral nucleic acid, proteins, or virions, can be encapsulated within exosomes and transferred between cells via exosomal transport. Consequently, exosomes play a crucial role in the infection of certain viral diseases. This review presents recent findings on the interplay between exosomes and autophagy, as well as their implications in the infection of enveloped viruses, thereby offering valuable insights into the pathogenesis and vaccine research of enveloped virus infection.

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“…Particularly, host-cell related pathways (e.g. transcriptional and mitochondrial processes) utilised by RVFV for its replication, are promising therapeutic targets for anti-RVFV drug development [116].…”

Section: Chalcone Derivatives Tested On Rift Valley Fevermentioning

confidence: 99%

A comprehensive review on the antiviral activities of chalcones

Elkhalifa

Al-Hashimi

Moustafa

et al. 2020

Journal of Drug Targeting

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Some viral outbreaks have plagued the world since antiquity, including the most recent COVID-19 pandemic. The continuous spread and emergence of new viral diseases have urged the discovery of novel treatment options that can overcome the limitations of currently marketed antiviral drugs. Chalcones are natural open chain flavonoids that are found in various plants and can be synthesised in labs. Several studies have shown that these small organic molecules exert a number of pharmacological activities, including antiviral, anti-inflammatory, antimicrobial and anticancer. The purpose of this review is to provide a summary of the antiviral activities of chalcones and their derivatives on a set of human viral infections and their potential for targeting the most recent COVID-19 disease. Accordingly, we herein review chalcones activities on the following human viruses: Middle East respiratory syndrome coronavirus, severe acute respiratory syndrome coronavirus, human immunodeficiency, influenza, human rhinovirus, herpes simplex, dengue, human cytomegalovirus, hepatitis B and C, Rift Valley fever and Venezuelan equine encephalitis. We hope that this review will pave the way for the design and development of potentially potent and broad-spectrum chalcone based antiviral drugs.

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Host-based processes as therapeutic targets for Rift Valley fever virus

Cited by 5 publications

References 153 publications

In silico identification of novel pre-microRNA genes in Rift valley fever virus suggest new pathomechanisms for embryo-fetal dysgenesis

In silico identification of novel pre-microRNA genes in Rift valley fever virus suggest new pathomechanisms for embryo-fetal dysgenesis

Exosome–Autophagy Crosstalk in Enveloped Virus Infection

A comprehensive review on the antiviral activities of chalcones

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