Host control by SPβ phage regulatory switch as potential manipulation strategy

Floccari, Valentina A; Dragoš, Anna

doi:10.1016/j.mib.2022.102260

Cited by 6 publications

(3 citation statements)

References 67 publications

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“…bacteriocin, sublancin that presumably benefit the fitness of the host bacterium (Butala & Dragoš, 2022;Dragoš, Andersen, et al, 2021;Dragoš, Priyadarshini, et al, 2021;Floccari & Dragoš, 2023). The Rap protein coded within the phi3T prophage has been also hypothesized to contribute to phage fitness (Bernard et al, 2021).…”

Section: Gallegos-monterrosaandkovácsmentioning

confidence: 99%

“…Similarly, experimental selection for spores of B. subtilis increases the copy number of a cryptic prophage, phi3T, that carries Rap and Phr proteins (Dragoš, Priyadarshini, et al, 2021; Martin et al, 2017). Interestingly, certain prophages, like SPβ, that are similar to phi3T do not carry such rap gene, but encode a biosynthetic gene cluster for a bacteriocin, sublancin that presumably benefit the fitness of the host bacterium (Butala & Dragoš, 2022; Dragoš, Andersen, et al, 2021; Dragoš, Priyadarshini, et al, 2021; Floccari & Dragoš, 2023). The Rap protein coded within the phi3T prophage has been also hypothesized to contribute to phage fitness (Bernard et al, 2021).…”

Section: Distribution and Diversity Of The Rap‐phr Family In The Baci...mentioning

confidence: 99%

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Phenotypic plasticity: The role of a phosphatase family Rap in the genetic regulation ofBacilli

Gallegos‐Monterrosa

Kovács

2023

Molecular Microbiology

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In the last two decades, an increasing number of bacterial species have been recognized that are able to generate a phenotypically diverse population that shares an identical genotype. This ability is dependent on a complex genetic regulatory network that includes cellular and environmental signals, as well as stochastic elements. Among Bacilli, a broadly distributed family of Rap (Response‐regulator aspartyl phosphate) phosphatases is known to modulate the function of the main phenotypic heterogeneity regulators by controlling their phosphorylation. Even more, their related extracellular Phr (Phosphatase regulator) peptides function as signals, creating a cell–cell communication network that regulates the phenotypic development of the entire population. In this review, we examine the role that the Rap phosphatases and their Phr peptides play in the regulation of Bacillus subtilis phenotypic differentiation, and in other members of the Bacillus genus. We also highlight the contribution of these regulatory elements to the fitness of bacterial cells and mobile genetic elements, for example, prophages and conjugative vectors.

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Section: Gallegos-monterrosaandkovácsmentioning

confidence: 99%

Section: Distribution and Diversity Of The Rap‐phr Family In The Baci...mentioning

confidence: 99%

Phenotypic plasticity: The role of a phosphatase family Rap in the genetic regulation ofBacilli

Gallegos‐Monterrosa

Kovács

2023

Molecular Microbiology

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“…They used a comK mutant as a recipient strain to prevent natural competence and utilized antibiotics as markers to select recipient strains carrying the transferred plasmid. The authors also considered the presence of prophages (SPβ) and other integrative and conjugative elements such as ICE Bs1 codified in the genome of B. subtilis 168 (Auchtung et al, 2016 ; Floccari & Dragoš, 2023 ), as they can be involved, directly or indirectly, in DNA transfer. Thus, they used a strain cured from these two elements to verify that the plasmid transfer they were visualizing was a cell‐to‐cell contact‐dependent process and not the result of conjugative events or induced prophage transduction (Morawska & Kuipers, 2022 ).…”

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confidence: 99%