Host defense against the infection of Klebsiella pneumoniae: New strategy to kill the bacterium in the era of antibiotics?

Liang, Zi-Han; Wang, Yiyao; Lai, Yixiang; Zhang, Jingyi; Yin, Li; Zhou, Yonggang; Li, Xinzhi; Song, Yinhong

doi:10.3389/fcimb.2022.1050396

Cited by 5 publications

(4 citation statements)

References 94 publications

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“…This dynamic interplay underscores the importance of understanding the complement system ’ s mechanisms and the bacterial strategies that challenge its efficacy. 12 , 13 …”

Section: Interaction Between K Pneumoniae Infectio...mentioning

confidence: 99%

“…Such targeted precision allows immune system cells, specifically neutrophils, to discern, assail, and ultimately eliminate the bacteria. 12 …”

Section: Treatment Strategies For K Pneumoniae Inf...mentioning

confidence: 99%

“…Such targeted precision allows immune system cells, specifically neutrophils, to discern, assail, and ultimately eliminate the bacteria. 12 Recent studies highlight the potential of monoclonal antibodies in treating diseases caused by K. pneumoniae. Monoclonal antibodies, meticulously crafted in laboratories, serve as synthetic counterparts that either mimic or augment the immune system's assault on this bacterial strain.…”

Section: Antibody Therapymentioning

confidence: 99%

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Interactions and Implications of Klebsiella pneumoniae with Human Immune Responses and Metabolic Pathways: A Comprehensive Review

Bai,

Guo

2024

IDR

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Klebsiella pneumoniae ( K. pneumoniae ), a significant contributor to the global challenge of antibiotic resistance, is not only a ubiquitous component of the human microbiome but also a potent pathogen capable of causing a spectrum of diseases. This review provides a thorough analysis of the intricate interactions between K. pneumoniae and the human immune system, elucidating its substantial impact on metabolic processes. We explore the mechanisms employed by K. pneumoniae to evade and manipulate immune responses, including molecular mimicry, immune modulation, and biofilm formation. The review further investigates the bacterium ’ s influence on metabolic pathways, particularly glycolysis, highlighting how these interactions exacerbate disease severity. The emergence of multidrug-resistant and extremely drug-resistant strains within the Enterobacteriaceae family has heightened the public health crisis, underscoring the urgency for comprehensive research. We investigate the roles of the host’s complement system, autophagy, cell death mechanisms, and various cytokines in combating K. pneumoniae infections, shedding light on areas that warrant further academic investigation. Additionally, the review discusses the challenges posed by K1- and K2-capsule polysaccharides in vaccine development due to their complex molecular structures and adhesive properties. Acknowledging the limited availability of effective antimicrobials, this review advocates for exploring alternative approaches such as immunotherapeutics, vaccinations, and phage therapy. We consolidate current knowledge on K. pneumoniae , covering classical and non-classical subtypes, antimicrobial resistance-mediated genes, virulence factors, and epidemiological trends in isolation and antibiotic resistance rates. This comprehensive review not only advances our understanding of K. pneumoniae but also underscores the imperative for ongoing research and collaborative efforts to develop new prevention and treatment strategies against this formidable pathogen.

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“…This dynamic interplay underscores the importance of understanding the complement system ’ s mechanisms and the bacterial strategies that challenge its efficacy. 12 , 13 …”

Section: Interaction Between K Pneumoniae Infectio...mentioning

confidence: 99%

“…Such targeted precision allows immune system cells, specifically neutrophils, to discern, assail, and ultimately eliminate the bacteria. 12 …”

Section: Treatment Strategies For K Pneumoniae Inf...mentioning

confidence: 99%

Section: Antibody Therapymentioning

confidence: 99%

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Interactions and Implications of Klebsiella pneumoniae with Human Immune Responses and Metabolic Pathways: A Comprehensive Review

Bai,

Guo

2024

IDR

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“…Host signaling pathways that contribute to an effective airway immune response against K. pneumoniae have been thoroughly investigated [ 20 ] . IL-17 is especially important as it protects from both K. pneumoniae pathotypes.…”

Section: K Pneumoniae Pathotypesmentioning

confidence: 99%

Immunometabolic control by Klebsiella pneumoniae

Prince

Lung

2023

Immunometabolism

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Klebsiella pneumoniae is a common Gram-negative pathogen associated with community-acquired and healthcare-associated infections. Its ability to acquire genetic elements resulted in its rapid development of resistance to virtually all antimicrobial agents. Once infection is established, K. pneumoniae is able to evade the host immune response and perhaps more importantly, undergo metabolic rewiring to optimize its ability to maintain infection. K. pneumoniae lipopolysaccharide and capsular polysaccharide are central factors in the induction and evasion of immune clearance. Less well understood is the importance of immunometabolism, the intersection between cellular metabolism and immune function, in the host response to K. pneumoniae infection. Bacterial metabolism itself is perceived as a metabolic stress to the host, altering the microenvironment at the site of infection. In this review, we will discuss the metabolic responses induced by K. pneumoniae, particularly in response to stimulation with the metabolically active bacteria versus pathogen-associated molecular patterns alone, and their implications in shaping the nature of the immune response and the infection outcome. A better understanding of the immunometabolic response to K. pneumoniae may help identify new targets for therapeutic intervention in the treatment of multidrug-resistant bacterial infections.

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Klebsiella pneumoniae: adaptive immune landscapes and vaccine horizons

Wantuch,

Rosen

2023

Trends in Immunology

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Host defense against the infection of Klebsiella pneumoniae: New strategy to kill the bacterium in the era of antibiotics?

Cited by 5 publications

References 94 publications

Interactions and Implications of Klebsiella pneumoniae with Human Immune Responses and Metabolic Pathways: A Comprehensive Review

Interactions and Implications of Klebsiella pneumoniae with Human Immune Responses and Metabolic Pathways: A Comprehensive Review

Immunometabolic control by Klebsiella pneumoniae

Klebsiella pneumoniae: adaptive immune landscapes and vaccine horizons

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