Host‐derived biomarkers at teeth and implants in partially edentulous patients. A 10‐year retrospective study

Abstract

Increased levels of MMP-8 and IL-1β in PISF or GCF may be associated with inflammation around teeth and implants while lower levels of MMP-1/TIMP-1 may be an indicator of disease progression around implants.

Clinical and radiographic peri‐implant parameters and proinflammatory cytokine levels among cigarette smokers, smokeless tobacco users, and nontobacco users

“…18,19 Moreover, research indicates that nicotine in tobacco upregulates the secretion of proinflammatory cytokines (such as IL-1b and MMP-9), which play a key role in alveolar bone deterioration around natural teeth. 20,21 Increased expression of these proinflammatory cytokines have also been detected in the PISF of patients with peri-implantitis. 22,23 Furthermore, findings from a recent meta-analysis showed that tobacco smoking impairs new bone formation around dental implants and jeopardizes bone-to-implant contact.…”

Peri-Implant Crevicular Fluid Analysis, Enzymes and Biomarkers: a Systemetic Review

“…One of them reported no significant change after de novo plaque accumulation [25]. Thirteen studies showed higher levels of IL-1β in PICF than healthy implant sites [7,21,22,30,35,36,41-47]. Of the 10 studies assessed TNF-α, 3 of them showed no relationship with this cytokine with peri-implant inflammation [7,25,43], while other 7 studies showed significant relationship with this cytokine [23,24,36,41,46-48].…”

The evaluation of peri‐implant sulcus fluid osteocalcin, osteopontin, and osteonectin levels in peri‐implant diseases

“…Up to date, several studies have examined different biologic mediators such as interleukin 1 beta, prostoglandin, matrix metalloproteinases, and proteolytic enzymes in peri‐implant diseases . However, there are very limited number of studies evaluating PISF osteocalcin, osteopontin, and osteonectin levels in different peri‐implant diseases.…”