Host Factors Independently Associated With Prognosis in Patients With Oral Cavity Cancer

Valero, Cristina; Zanoni, Daniella Karassawa; Pillai, Anjali; Ganly, Ian; Morris, Luc G.T.; Shah, Jatin P.; Wong, Richard J.; Patel, Snehal G.

doi:10.1001/jamaoto.2020.1019

Cited by 32 publications

(63 citation statements)

References 47 publications

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“…Albumin (Alb) and fibrinogen (Fib) are two commonly used circulating inflammatory proteins. Alb has been reported to be a well-established prognostic factor in patients with various diseases, including oral cavity cancer [10], metastatic pathological femur fractures [11], and amyotrophic lateral sclerosis [12]. Moreover, the prognostic role of Fib has also been reported in various studies, such as spontaneous intracerebral haemorrhage [13] and surgically resected non-small-cell lung cancer [14].…”

Section: Introductionmentioning

confidence: 97%

Preoperative fibrinogen-to-albumin ratio, a potential prognostic factor for patients with stage IB-IIA cervical cancer

Liu

Yang

et al. 2020

BMC Cancer

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Background: Previous studies have shown that fibrinogen-to-albumin ratio (FAR) is a novel prognostic immune biomarker in various diseases. In this study, we investigated the role of FAR in the prognosis of patients with stage IB-IIA cervical cancer (CC). Methods: A total of 278 eligible participants with newly diagnosed CC (stage IB-IIA) who had undergone radical hysterectomy followed by adjuvant chemotherapy were enrolled in this study. Demographics, clinicopathological variables, and laboratory tests were obtained from the medical records. Risk factors for overall survival (OS) and recurrence-free survival (RFS) were evaluated by univariate and multivariate Cox proportional regression analyses. The association between OS, RFS, and FAR was assessed by the Kaplan-Meier method using log-rank test. Results: FAR was associated with age, International Federation of Gynecology and Obstetrics (FIGO) stage, depth of the invasion, and C-reactive protein (CRP) level (P < 0.05). Preoperative FAR was an effective predictor for OS in CC patients with a cutoff value of 7.75 and an area under the curve (AUC) of 0.707 (P < 0.001). The univariate and multivariate Cox analyses indicated that FIGO stage and FAR were two independent risk factors for both OS and RFS (P < 0.05). Kaplan-Meier analysis confirmed that patients with high FAR levels showed significantly lower RFS (P = 0.004) and OS (P = 0.003) than those with low FAR levels. Conclusions: This study indicated that elevated preoperative FAR might be a novel prognostic factor for CC patients with stage IB-IIA.

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Section: Introductionmentioning

confidence: 97%

Preoperative fibrinogen-to-albumin ratio, a potential prognostic factor for patients with stage IB-IIA cervical cancer

Liu

Yang

et al. 2020

BMC Cancer

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“… 7 , 8 , 9 , 10 Albumin and fibrinogen are the two most common biomarkers of inflammation. Recent studies reported that albumin was associated with the prognosis of many diseases, such as Oral Cavity cancer, 11 metastatic pathological femur fractures, 12 and amyotrophic lateral sclerosis. 13 Besides, previous studies showed that fibrinogen has the function of predicting the prognosis of diseases, such as spontaneous cerebral hemorrhage 14 and renal cancer.…”

Section: Introductionmentioning

confidence: 99%

The prognostic value of sarcopenia combined with preoperative fibrinogen–albumin ratio in patients with intrahepatic cholangiocarcinoma after surgery: A multicenter, prospective study

Wang

et al. 2021

Cancer Medicine

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“…Several inflammatory indices based on peripherical white blood cell counts, including lymphocyte-to-neutrophil ratio (LNR) [10], systemic inflammatory marker (SIM) [11], prognostic nutritional index (PNI) [12], and H-Index [13], have been proposed to provide health researchers with more comprehensive and accurate prognostication.…”

Section: Introductionmentioning

confidence: 99%

Advanced lung cancer inflammation index and its prognostic value in HPV-negative head and neck squamous cell carcinoma: a multicentre study

Gaudioso

Borsetto

Tirelli

et al. 2021

Support Care Cancer

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Purpose The aim of this study is to evaluate the prognostic value of pre-treatment advanced lung cancer inflammation index (ALI) in patients with HPV-negative HNSCC undergoing up-front surgical treatment. Methods The present multi-centre, retrospective study was performed in a consecutive cohort of patients who underwent upfront surgery with or without adjuvant (chemo)-radiotherapy for head and neck squamous cell carcinoma (HNSCC). Patients were stratified by ALI, and survival outcomes were compared between groups. In addition, the prognostic value of ALI was compared with two other indices, the prognostic nutritional index (PNI) and systemic inflammatory index (SIM). Results Two hundred twenty-three patients met the inclusion criteria (151 male and 72 female). Overall and progression-free survival were significantly predicted by ALI < 20.4 (HR 3.23, CI 1.51–6.90 for PFS and HR 3.41, CI 1.47–7.91 for OS). Similarly, PNI < 40.5 (HR = 2.43, 95% CI: 1.31–4.51 for PFS and HR = 2.40, 95% CI: 1.19–4.82 for OS) and SIM > 2.5 (HR = 2.51, 95% CI: 1.23–5.10 for PFS and HR = 2.60, 95% CI: 1.19–5.67 for OS) were found to be significant predictors. Among the three indices, ALI < 20.4 identified the patients with the worst 5-year outcomes. Moreover, patients with a combination of low PNI and low ALI resulted to be a better predictor of progression (HR = 5.26, 95% CI: 2.01–13.73) and death (HR = 5.68, 95% CI: 1.92–16.79) than low ALI and low PNI considered alone. Conclusions Our results support the use of pre-treatment ALI, an easily measurable inflammatory/nutritional index, in daily clinical practice to improve prognostic stratification in surgically treated HPV-negative HNSCC.

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Host Factors Independently Associated With Prognosis in Patients With Oral Cavity Cancer

Cited by 32 publications

References 47 publications

Preoperative fibrinogen-to-albumin ratio, a potential prognostic factor for patients with stage IB-IIA cervical cancer

Preoperative fibrinogen-to-albumin ratio, a potential prognostic factor for patients with stage IB-IIA cervical cancer

The prognostic value of sarcopenia combined with preoperative fibrinogen–albumin ratio in patients with intrahepatic cholangiocarcinoma after surgery: A multicenter, prospective study

Advanced lung cancer inflammation index and its prognostic value in HPV-negative head and neck squamous cell carcinoma: a multicentre study

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