Host Genetic Risk Factors Associated with COVID-19 Susceptibility and Severity in Vietnamese

Nhung, Vũ Phương; Ton, Nguyen Dang; Ngọc, Trần Thị Bích; Thuong, Ma Thi Huyen; Hai, Nguyen Thi Thanh; Oanh, Kim Thi Phuong; Hiền, Lê Thị Thu; Thach, Pham Ngoc; Hải, Nông Văn; Hà, Nguyễn Hải

doi:10.3390/genes13101884

Cited by 17 publications

(12 citation statements)

References 44 publications

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“…Heterogeneous findings were observed regarding the correlation between genetic variations and COVID-19 susceptibility and severity [ 8 , 9 , 45 – 47 ].…”

Section: Resultsmentioning

confidence: 99%

HLA alleles associated with COVID-19 susceptibility and severity in different populations: a systematic review

Fakhkhari

Caidi

Sadki

2023

Egypt J Med Hum Genet

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Background COVID-19 is a respiratory disease caused by a novel coronavirus called as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Detected for the first time in December 2019 in Wuhan and it has quickly spread all over the world in a couple of months and becoming a world pandemic. Symptoms of the disease and clinical outcomes are very different in infected people. These differences highlight the paramount need to study and understand the human genetic variation that occurring viral infections. Human leukocyte antigen (HLA) is an important component of the viral antigen presentation pathway, and it plays an essential role in conferring differential viral susceptibility and severity of diseases. HLA alleles have been involved in the immune response to viral diseases such as SARS-CoV-2. Main body of the abstract Herein, we sought to evaluate this hypothesis by summarizing the association between HLA class I and class II alleles with COVID-19 susceptibility and/or severity reported in previous studies among different populations (Chinese, Italian, Iranian, Japanese, Spanish, etc.). The findings of all selected articles showed that several alleles have been found associated with COVID-19 susceptibility and severity. Even results across articles have been inconsistent and, in some cases, conflicting, highlighting that the association between the HLA system and the COVID‐19 outcome might be ethnic‐dependent, there were some alleles in common between some populations such as HLA-DRB1*15 and HLA-A*30:02. Conclusion These contradictory findings warrant further large, and reproducible studies to decipher any possible genetic predisposition underlying susceptibility to SARS-COV-2 and disease progression and host immune response.

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“…Heterogeneous findings were observed regarding the correlation between genetic variations and COVID-19 susceptibility and severity [ 8 , 9 , 45 – 47 ].…”

Section: Resultsmentioning

confidence: 99%

HLA alleles associated with COVID-19 susceptibility and severity in different populations: a systematic review

Fakhkhari

Caidi

Sadki

2023

Egypt J Med Hum Genet

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“…To be more precise, rs2531743 is located at 3p21.31, which has been previously linked to COVID-19 outcomes in eleven GWAS. SLC6A20 has been shown to interact with ACE2 in the membrane of small intestinal enterocytes, suggesting a relationship with COVID-19 illness [ 23 ]. Recent research has also demonstrated a link between SARS-CoV-2 sensitivity and SLC6A20 gene variants in Vietnamese [ 23 ] and Native American [ 33 ] populations.…”

Section: Discussionmentioning

confidence: 99%

“…SLC6A20 has been shown to interact with ACE2 in the membrane of small intestinal enterocytes, suggesting a relationship with COVID-19 illness [ 23 ]. Recent research has also demonstrated a link between SARS-CoV-2 sensitivity and SLC6A20 gene variants in Vietnamese [ 23 ] and Native American [ 33 ] populations. In addition, it was suggested that SLC6A20 is a novel regulator of glycine levels [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

“…Disease susceptibility (cases) was assigned based on a positive PCR test or a reported suspected COVID-19 illness. All cases indicated a mild (absence of any shortness of breath, dyspnea, or abnormal chest imaging) or moderate (individuals with a febrile temperature lasting for at least one week or lower respiratory tract inflammation but SpO 2 > 94%) disease course without hospitalization, as previously classified [ 23 ]. Subjects were classified as resistant to SARS-CoV-2 infection (controls) if they reported an absence of COVID-19 infection during the first three waves of the COVID-19 pandemic prior to their individual vaccination against SARS-CoV-2.…”

Section: Methodsmentioning

confidence: 99%

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Host Genetic Variants Linked to COVID-19 Neurological Complications and Susceptibility in Young Adults—A Preliminary Analysis

Казанцева

Enikeeva

Takhirova³

et al. 2023

JPM

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To date, multiple efforts have been made to use genome-wide association studies (GWAS) to untangle the genetic basis for SARS-CoV-2 infection susceptibility and severe COVID-19. However, data on the genetic-related effects of SARS-CoV-2 infection on the presence of accompanying and long-term post-COVID-19 neurological symptoms in younger individuals remain absent. We aimed to examine the possible association between SNPs found in a GWAS of COVID-19 outcomes and three phenotypes: SARS-CoV-2 infection, neurological complications during disease progression, and long-term neurological complications in young adults with a mild-to-moderate disease course. University students (N = 336, age 18–25 years, European ancestry) with or without COVID-19 and neurological symptoms in anamnesis comprised the study sample. Logistic regression was performed with COVID-19-related phenotypes as outcomes, and the top 25 SNPs from GWAS meta-analyses and an MR study linking COVID-19 and cognitive deficits were found. We replicated previously reported associations of the FURIN and SLC6A20 gene variants (OR = 2.36, 95% CI 1.31–4.24) and OR = 1.94, 95% CI 1.08–3.49, respectively) and remaining neurological complications (OR = 2.12, 95% CI 1.10–4.35 for SLC6A20), while NR1H2 (OR = 2.99, 95% CI 1.39–6.69) and TMPRSS2 (OR = 2.03, 95% CI 1.19–3.50) SNPs were associated with neurological symptoms accompanying COVID-19. Our findings indicate that genetic variants related to a severe COVID-19 course in adults may contribute to the occurrence of neurological repercussions in individuals at a young age.

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“…Major risk factors for severe disease complications (and death) include demographic characteristics (male sex and age above 65 years) and co-morbidities such as obesity 7,8 , hypertension, diabetes, chronic pulmonary, renal, respiratory or liver disease, immunode ciencies, cancer, and cardiovascular disease, but these factors do not fully explain the wide range of clinical severity 9,10 . A possible explanation for these ndings is that the host genetic variations affecting the structure or function of essential proteins play a critical role in the entry and spread of SARS-CoV-2 and determine the severity of COVID-19 course and outcome 11 .…”

Section: Introductionmentioning

confidence: 99%

Rare host variants in ciliary expressed genes contribute to COVID-19 severity in Bulgarian patients

Kamenarova,

Kachakova-Yordanova,

Baymakova

et al. 2024

Preprint

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Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), a pneumonia with extremely heterogeneous clinical presentation, ranging from asymptomatic to severely ill patients. Previous studies have reported links between the presence of host genetic variants and the outcome of the COVID-19 infection. In our study, we used whole exome sequencing in a cohort of 444 SARS-CoV-2 patients, admitted to hospital in the period October-2020-April-2022, to search for associations between rare pathogenic/potentially pathogenic variants and COVID-19 progression. We used gene prioritization-based analysis in genes that have been reported by host genetic studies. Although we did not identify correlation between the presence of rare pathogenic variants and COVID-19 outcome, in critically ill patients we detected known mutations in a number of genes associated with severe disease related to cardiovascular disease, primary ciliary dyskinesia, cystic fibrosis, DNA damage repair response, coagulation, primary immune disorder, hemoglobin subunit β, and others. Additionally, we report 93 novel pathogenic variants found in severely infected patients who required intubation or died. A network analysis showed main component, consisting of 13 highly interconnected genes related to epithelial cilium. In conclusion, we have detected rare pathogenic host variants that may have influenced the COVID-19 outcome in Bulgarian patients.

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Host Genetic Risk Factors Associated with COVID-19 Susceptibility and Severity in Vietnamese

Cited by 17 publications

References 44 publications

HLA alleles associated with COVID-19 susceptibility and severity in different populations: a systematic review

HLA alleles associated with COVID-19 susceptibility and severity in different populations: a systematic review

Host Genetic Variants Linked to COVID-19 Neurological Complications and Susceptibility in Young Adults—A Preliminary Analysis

Rare host variants in ciliary expressed genes contribute to COVID-19 severity in Bulgarian patients

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