Host–guest inclusion complexation of β-cyclodextrin and hecogenin acetate to enhance anti-hyperalgesic effect in an animal model of musculoskeletal pain

Quintans, Jullyana S.S.; Pereira, Erik Willyame Menezes; Carvalho, Yasmim Maria Barbosa Gomes de; Menezes, Paula P.; Serafini, Mairim Russo; Batista, Marcus Vinícius de Aragão; Moreira, Carlos D.L.F.A.; Lima, Alexandre A. B.; Branco, Alexsandro; Almeida, Jackson R.G.S.; Gelain, Daniel Pens; Zengin, Gökhan; Araújo, Adriano A. S.; Quintans‐Júnior, Lucindo José

doi:10.1016/j.procbio.2016.08.025

Cited by 16 publications

(11 citation statements)

References 47 publications

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“…However, the HA/β-CD complex was superior in producing an analgesic profile using lower nominal doses of the active principle (HA). In addition, the interaction of the HA with opioid receptors and a decrease in SP levels in the lumbar spinal cord were verified, which indicate participation of this substance in the descending inhibitory pain pathway [33,85].…”

Section: Discussion Of Unusual Topics In Fibromyalgiamentioning

confidence: 83%

“…Quintans et al [33] evaluated the effect of hecogenin acetate (HA), an acetylated steroidal saponin, complexed with β-CD in a chronic noninflammatory widespread pain model. Hecogenin is already used in the pharmaceutical industry to synthesize some oral contraceptive agents.…”

Section: Discussion Of Unusual Topics In Fibromyalgiamentioning

confidence: 99%

“…Moreover, β-caryophyllene, a major compound of H. pectinata leaf essential oil (HpEO), complexed with β-cyclodextrin decreased Fos protein expression in the superficial dorsal horn, which seems to involve the descending inhibitory pain system in an animal model of FM (Figure 2(C)). Germacrene D, another major component Vehicle or β-caryophyllene-β-cyclodextrin (20 mg/kg) was administered orally, and, after 90 min, the animals were perfused (adapted from Quintans-Júnior et al [25,33]). …”

Section: Preclinical Studiesmentioning

confidence: 99%

“…In relation to FM, some classes of bioactive compounds extracted from medicinal plants have presented analgesic activity described in the literature, such as essential oils [24][25][26], extracts [27,28], monoterpenes [29][30][31], sesquiterpenes [32], saponins [33], and alkaloids ( Figure 1 and Table 2) [34]. * All preclinical studies used the chronic muscle pain model induced by acid saline.…”

Section: Introductionmentioning

confidence: 99%

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Natural Products as Promising Pharmacological Tools for the Management of Fibromyalgia Symptoms – A Review

Brito¹,

Santos²,

AlmeidaOliveira³

et al. 2018

Discussions of Unusual Topics in Fibromyalgia

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Fibromyalgia (FM) is the second most common rheumatologic disorder, affecting 5% of the world population, and has a serious effect on the quality of life of patients, as well as an economic impact through lost workdays. This pain syndrome is a common cause of chronic widespread pain and is characterized by reduced pressure pain thresholds with hyperalgesia and allodynia, nonrestorative sleep, fatigue, cognitive dysfunction, and mood disturbances. The pharmacological treatment strategies for FM include the use of antidepressants, calcium channel modulators, muscle relaxants, and analgesics but have shown limited efficacy and therapeutic adherence. Thus, researchers have been seeking potential substances (new chemical entities or through drug repositioning) that could be used for FM treatment. In this context, natural products (NPs) have been shown to be promising pharmacological tools due to the variety of their pharmacological activity and the number of molecular sites available as possible active targets. Recent clinical and preclinical studies have been conducted to verify the possible applicability of NPs such as essential oils (EOs), plants extracts, terpenes, sapogenins, and alkaloids in the treatment of FM. The results have shown that natural products have an analgesic effect in different animal models of FM, probably by activation of inhibitory descending pathways, such as the periaqueductal gray and rostroventromedial medulla. Natural products and their secondary metabolites could therefore be a promising source for FM management. However, translational studies that seek to validate the preclinical studies are scarce, incipient, and lacking an approach focused on the traditional pharmaceutical market.

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Section: Discussion Of Unusual Topics In Fibromyalgiamentioning

confidence: 83%

Section: Discussion Of Unusual Topics In Fibromyalgiamentioning

confidence: 99%

Section: Preclinical Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Natural Products as Promising Pharmacological Tools for the Management of Fibromyalgia Symptoms – A Review

Brito¹,

Santos²,

AlmeidaOliveira³

et al. 2018

Discussions of Unusual Topics in Fibromyalgia

Self Cite

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“…As the authors established, the functionalization of silicone-based materials with ACNSs are promising potential platforms for the prevention of biofilm-associated infections caused by E. coli. The role of cyclodextrines (CD) as inclusion complexes was evaluated for fibromialgy treatment by complexation with a steroidal acetylated-sapogenin, hecogenin acetate (HA) [13]. The aim was to improve the anti-hyperalgesic effect of HA in a non-inflammatory animal model of musculoskeletal pain (considered to be a suitable animal model for FM), evaluating its effectiveness by examining its effect on substance P (SP) in the spinal cord, and its influence on the opioid system.…”

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confidence: 99%

Foreword: Advances in “Polymer/Fibre Biotechnology”

Silva

Cavaco-Paulo

2017

Process Biochemistry

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Biotechnology has been applied as a valuable tool to produce useful bio-based products from non-petrochemical renewable resources. Biologically produced polymers present advantages related with the biodegradability, performance, cheapness of substrate and defined structural variability. Beyond that, enzymes, the most proficient catalysts, continue to offer the most competitive processes compared with the chemical ones. Advances in protein engineering technology and the environmental and economic requirements contribute for the continuous search of acceptable biotechnological solutions for the areas, including, polymer and textile, medical, pharmaceutical, among others. New trends and strategies have been highlighted in recent studies leading to significant advances in enzyme biocatalysis.

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Competitive Host‐guest Electrochemical Detection of Ivermectin Drug Using a β‐Cyclodextrin/Graphene‐based Electrode

et al. 2022

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The present study describes the novel development and application of an ivermectin (IVM) sensing electrochemical platform based on reduced graphene oxide (rGO) and the macrocyclic host β-cyclodextrin (β-CD) molecule. The sensing method was based in the hostguest characteristics of β-CD and competitive interaction between the target analyte and the methylene blue (MB) redox probe. Differential pulse voltammetry (DPV) was employed for the detection of IVM and a linear response between 0.5 and 40.0 μmol L À 1 with a limit of detection of 0.25 μmol L À 1 was obtained using the glassy carbon (GC)/ rGO/β-CD electrode. The sensing platform was successfully applied for the detection of IVM in tap water samples, which may expand the applications of β-CD towards the analysis of other chemical species.

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Host–guest inclusion complexation of β-cyclodextrin and hecogenin acetate to enhance anti-hyperalgesic effect in an animal model of musculoskeletal pain

Cited by 16 publications

References 47 publications

Natural Products as Promising Pharmacological Tools for the Management of Fibromyalgia Symptoms – A Review

Natural Products as Promising Pharmacological Tools for the Management of Fibromyalgia Symptoms – A Review

Foreword: Advances in “Polymer/Fibre Biotechnology”

Competitive Host‐guest Electrochemical Detection of Ivermectin Drug Using a β‐Cyclodextrin/Graphene‐based Electrode

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