Host Intestinal Epithelium Derived Mirnas Shape the Microbiota and Its Implication in Cardiovascular Diseases

Zhao, Lianbi; Zhou, Xueying; Cai, Wenbin; Shi, Ruijing; Yang, Guodong; Yuan, Lijun

doi:10.1016/s0735-1097(17)34464-9

Cited by 9 publications

(10 citation statements)

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“…Authors stated that miRNAs that correlated with CRC-associated bacteria are predicted to control targets that are central for host-microbiome relations and reported a possible action for miRNA-driven glycan production in the enrolment of pathogenic microbial taxa [56]. Several results allow to hypothesise a global relationship between microbial structure and miRNA expression in human CRC [57,58].…”

Section: Microbiota and Colorectal Cancermentioning

confidence: 99%

“…However, the systems by which miRNAs enter bacteria and affect specific mRNA transcription are not well-defined. In vivo researches reported that miRNAs could enter the bacteria via endocytosis [58]. Moreover, it has been demonstrated that CRC cells harbouring mutant p53 selectively discard exosomes enriched with miRNA-1246, a possible biomarker for CRC [59].…”

Section: Microbiota and Colorectal Cancermentioning

confidence: 99%

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Interactions between the MicroRNAs and Microbiota in Cancer Development: Roles and Therapeutic Opportunities

Allegra

Musolino

Tonacci

et al. 2020

Cancers

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The human microbiota is made up of the fungi, bacteria, protozoa and viruses cohabiting within the human body. An altered microbiota can provoke diseases such as cancer. The mechanisms by which a modified microbiota can intervene in the onset and progression of neoplastic diseases are manifold. For instance, these include the effects on the immune system and the onset of obesity. A different mechanism seems to be constituted by the continuous and bidirectional relationships existing between microbiota and miRNAs. MiRNAs emerged as a novel group of small endogenous non-coding RNAs from that control gene expression. Several works seem to confirm the presence of a close connection between microbiota and miRNAs. Although the main literature data concern the correlations between microbiota, miRNAs and colon cancer, several researches have revealed the presence of connections with other types of tumour, including the ovarian tumour, cervical carcinoma, hepatic carcinoma, neoplastic pathologies of the central nervous system and the possible implication of the microbiota-miRNAs system on the response to the treatment of neoplastic pathologies. In this review, we summarise the physiological and pathological functions of the microbiota on cancer onset by governing miRNA production. A better knowledge of the bidirectional relationships existing between microbiota and miRNAs could provide new markers for the diagnosis, staging and monitoring of cancer and seems to be a promising approach for antagomir-guided approaches as therapeutic agents.

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Section: Microbiota and Colorectal Cancermentioning

confidence: 99%

Section: Microbiota and Colorectal Cancermentioning

confidence: 99%

Interactions between the MicroRNAs and Microbiota in Cancer Development: Roles and Therapeutic Opportunities

Allegra

Musolino

Tonacci

et al. 2020

Cancers

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“…However, the mechanisms by which miRNAs enter bacteria and interfere with specific mRNA transcription are not clear. A recent report showed that miRNAs could possibly enter the bacteria within endocytosis in in vitro experiments ( Zhao et al, 2017 ). Delivery of miR155/let7g not only altered the microbiota, but also influenced cardiovascular function ( Zhao et al, 2017 ).…”

Section: Gut Microbiota–mirna Interactions In Physiology and Diseasementioning

confidence: 99%

“…A recent report showed that miRNAs could possibly enter the bacteria within endocytosis in in vitro experiments ( Zhao et al, 2017 ). Delivery of miR155/let7g not only altered the microbiota, but also influenced cardiovascular function ( Zhao et al, 2017 ). Therefore, it could be believed that these intestinal miRNAs from IEC or other tissues might shape the gut microbiota and then induce dysbiosis.…”

Section: Gut Microbiota–mirna Interactions In Physiology and Diseasementioning

confidence: 99%

Gut Microbiota: An Integral Moderator in Health and Disease

2018

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The gut microbiota, as the main member in gut microecology, is an essential mediator in health and disease. The gut microbiota interacts with various organs and systems in the body, including brain, lung, liver, bone, cardiovascular system, and others. Microbiota-derived metabolites such as the short chain fatty acid (SCFA) butyrate are primary signals, which link the gut microbiota and physiology. Recently, the gut microbiota has been identified as the origin of a number of diseases by influencing the related cell signaling pathways such as WNT/beta-catenin pathway in colorectal cancer and T cell receptor signaling in the central nervous system. Moreover, several microRNAs participate in signaling networks through the intervention of the gut microbiota. The interaction between the gut microbiota and miRNAs plays a crucial role in vascular dysfunction and hepatocellular carcinoma (HCC). In this review, we will report and discuss recent findings about the crosstalk between the gut microbiota and physical organs and how the gut microbiota and miRNAs regulate each other while influencing the host via genes, proteins, or metabolites.

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“…Finally, human endogenous miR excreted by IECs, and called faecal miRNA, are known to shape intestinal commensal microbes [411,412]. It has been shown that IEC's miRNAs are absorbed by the microbiota [413] and modulate the gene transcripts affecting bacterial growth [414]. This is part of the complex regulatory networks of host pathogen interaction [202].…”

Section: Gut-microbiome-diet Interactionmentioning

confidence: 99%

Recent Advances In Nutritional Sciences: An Overview Of Glycans And MiRNAs

Menapace¹

2018

J Nutr Food Sci

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There are many nutritional substances that humans consume on a daily basis: water, carbohydrates lipids and proteins are main biochemical components of food. But others in a smaller amount are vitamins minerals and enzymes. At a possibly lesser quantity are glycans and miRNAs. The presence of oligoglycans in all food sources has been an established fact for many years. These special carbohydrates are present as glycoconjugates (glycoproteins or glycolipids) in and on the surface of all the cells (glycocalyx) of all organisms that we eat and remain intact through the GI tract as we lack the enzymatic repertoire of the human body to unbind their particular β-linkages. Glycans bind to naturally present human lectins (through protein-carbohydrate interactions), but also with other human glycans (through carbohydrate-carbohydrate interactions, or CCI). Moreover, these glycans, like fibres, are digested by the gut microbiota that resides within the intestine. As our biochemistry shapes the composition of the microbiome, so does the composition of glycans and foods that we consume, triggering biological responses. miRNAs are small, single-stranded, 19-to 23-nucleotide-long RNA molecules and affect the stability of messenger RNA (mRNA) influencing protein synthesis. miRNAs are also present in foods and act on both the microbial composition in our gut and may be absorbed by the walls of the GI tract, demonstrating resistance to food processing and enzymatic attack. Though still a topic of controversy, these small, noncoding RNAs that control gene expression may directly enter into the circulating miRNA population of dietary exogenous miRNAs. It can hence be possible to identify a relationship between glycans and miRNAs in food on one side, microbiota composition on the other and the resultant health status of the host (immune system), on the third side.

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Host Intestinal Epithelium Derived Mirnas Shape the Microbiota and Its Implication in Cardiovascular Diseases

Cited by 9 publications

References 0 publications

Interactions between the MicroRNAs and Microbiota in Cancer Development: Roles and Therapeutic Opportunities

Interactions between the MicroRNAs and Microbiota in Cancer Development: Roles and Therapeutic Opportunities

Gut Microbiota: An Integral Moderator in Health and Disease

Recent Advances In Nutritional Sciences: An Overview Of Glycans And MiRNAs

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