Host miRNAs-microbiota interactions in gastric cancer

Yang, Yan; Huang, Yingying; Lin, Wei; Liu, Jin; Chen, Xiangliu; Chen, Chuanzhi; Yu, Xiaofei

doi:10.1186/s12967-022-03264-3

Cited by 9 publications

(9 citation statements)

References 92 publications

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“…It is urgently necessary to find a diagnostic method for GC. Accumulating evidence has demonstrated that ncRNAs participate in tumorigenesis by regulating invasion, proliferation, and migration ( Fonseca Cabral et al, 2020 ; Tan et al, 2020 ; Lu et al, 2021 ; Yang et al, 2022 ). As mentioned previously, ncRNAs are abnormally expressed in GC and their expression is significantly related to patients’ prognoses.…”

Section: Discussionmentioning

confidence: 99%

Non-coding RNAs regulate mitochondrial dynamics in the development of gastric cancer

Chen

Wei²,

Huang³

et al. 2023

Front. Mol. Biosci.

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Gastric cancer (GC) is a malignant cancer that reduces life expectancy worldwide. Although treatment strategies have improved, patients with GC still have poor prognoses. Hence, it is necessary to understand the molecular mechanisms of GC and to find new therapeutic targets. Mitochondrial dynamics and mitochondrial dysfunction are associated with cancer cell growth and progression. Numerous studies have reported that non-coding RNAs (ncRNAs) can participate in the occurrence and development of GC by regulating mitochondrial dynamics. Elucidating the crosstalk between ncRNAs and mitochondria would be helpful in preventing and treating GC. Herein, we review and summarize the functions of oncogenes and tumor suppressors in suppressing ncRNAs and regulating mitochondrial dynamics in GC tumor growth, proliferation, invasion and metastasis. This review provides new insights into the pathogenesis of and intervention for GC.

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Section: Discussionmentioning

confidence: 99%

Non-coding RNAs regulate mitochondrial dynamics in the development of gastric cancer

Chen

Wei²,

Huang³

et al. 2023

Front. Mol. Biosci.

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“…Given that altered miRNAs and pathogenic bacteria contribute to tumorigenesis via the different mechanisms (Yang et al, 2022), we hypothesize that integrating the two types of molecular changes across the different body fluids may have a synergetic effect on the diagnosis of lung cancer. Our results show that the combined analysis of miRNAs in plasma and bacterial genera in sputum yielded a better performance than does a single category of the biomarkers, and thus validates the hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Integrating miRNAs and Bacterial DNA for Early Detection of Lung Cancer

Shen

Zhou

Dhilipkannah

et al. 2023

Preprint

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Purpose The early detection is crucial for improved outcomes in lung cancer, which remains a leading cause of cancer-erelated deaths. There is an urgent need for precise molecular biomarkers to diagnose early-stage lung cancer. To address this, we assessed the potential of integrating diverse molecular biomarkers across both plasma and sputum to improve the accuracy of diagnosis, given the heterogeneous nature of lung cancer arising from multifactorial molecular aberrations. Methods We utilized droplet digital PCR to quantify miRNAs in plasma and bacterial DNA in sputum collected from 114 lung cancer patients and 121 cancer-free smokers. The participants were randomly divided into a development cohort and a validation cohort. Logistic regression models with constrained parameters were employed to optimize a signature with the highest sensitivity and specificity for early detection of lung cancer. Results The individual plasma miRNAs and sputum bacterial biomarkers had sensitivities of 62%-71% and specificities of 61%-79% for diagnosing lung cancer. A panel of plasma miRNA or sputum bacterial biomarkers produced sensitivities of 79%-85% and specificities of 74%-82%. An integrated signature comprising two miRNAs in plasma and three bacterial biomarkers in sputum was developed in the development cohort, and it exhibited a higher sensitivity (87%) and specificity (89%) in comparison to individual biomarkers. The signature's diagnostic value was confirmed in the validation cohort, regardless of tumor stage, histological type, and demo-graphic factors. Conclusion The integration of miRNA and bacterial biomarkers across both plasma and sputum samples offered an effective approach for the diagnosis of lung cancer.

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“…H. pylori infection of a host results in the production of miR-155 via the NF-κB pathway which subsequently inhibits IL-8. Furthermore, studies have shown that miR-146a has a regulatory role in H. pylori -associated GC [ 61 ]. It has also been reported that polymorphisms of miR-146a is associated with GC [ 62 ].…”

Section: The Role Of Micrornas and H Pylori In Gcmentioning

confidence: 99%

Performance of DNA Methylation on the Molecular Pathogenesis of Helicobacter pylori in Gastric Cancer; targeted therapy approach

et al. 2022

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Gastric cancer (GC) is a significant cause of cancer mortality which has led to focused exploration of the pathology of GC. The advent of genome-wide analysis methods has made it possible to uncover genetic and epigenetic fluctuation such as abnormal DNA methylation in gene promoter regions that is expected to play a key role in GC. The study of gastric malignancies requires an etiological perspective, and Helicobacter pylori (H. pylori) was identified to play a role in GC. H. pylori infection causes chronic inflammation of the gastric epithelium causing abnormal polyclonal methylation, which might raise the risk of GC. In the last two decades, various pathogenic factors by which H. pylori infection causes GC have been discovered. Abnormal DNA methylation is triggered in several genes, rendering them inactive. In GC, methylation patterns are linked to certain subtypes including microsatellite instability. Multiple cancer-related processes are more usually changed by abnormal DNA methylation than through mutations, according to current general and combined investigations. Furthermore, the amount of acquired abnormal DNA methylation is heavily linked to the chances of developing GC. Therefore, we investigated abnormal DNA methylation in GC and the link between methylation and H. pylori infection.

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Host miRNAs-microbiota interactions in gastric cancer

Cited by 9 publications

References 92 publications

Non-coding RNAs regulate mitochondrial dynamics in the development of gastric cancer

Non-coding RNAs regulate mitochondrial dynamics in the development of gastric cancer

Integrating miRNAs and Bacterial DNA for Early Detection of Lung Cancer

Performance of DNA Methylation on the Molecular Pathogenesis of Helicobacter pylori in Gastric Cancer; targeted therapy approach

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