Host response to successive challenges with lentogenic and velogenic Newcastle disease virus in local chickens of Ghana

Botchway, Princess Korkor; Amuzu-Aweh, Esinam Nancy; Naazie, A.; Aning, G.; Otsyina, H. R.; Saelao, Perot; Wang, Y.; Zhou, Huaijun; Walugembe, Muhammed; Dekkers, Jack; Lamont, Susan J.; Gallardo, Rodrigo A.; Kelly, T. Ross; Bunn, David; Kayang, Boniface B.

doi:10.1016/j.psj.2022.102138

Cited by 3 publications

(2 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Newcastle disease ( ND ) is caused by virulent Newcastle disease virus ( NDV ) infection, which is a highly contagious disease of avian species that usually causes great economic losses to the poultry industry worldwide ( Botchway et al, 2022 ). NDV belongs to the genus Orthoavulavirus in the Paramyxoviridae family, which contains a single-stranded, negative-sense, nonsegmented RNA genome that encodes 6 structural and 2 nonstructural proteins ( Duan et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Chicken speckle-type POZ protein (SPOP) negatively regulates MyD88/NF-κB signaling pathway mediated proinflammatory cytokine production to promote the replication of Newcastle disease virus

Meng,

Wang,

Kong

et al. 2024

Poultry Science

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Chicken speckle-type POZ protein (SPOP) negatively regulates MyD88/NF-κB signaling pathway mediated proinflammatory cytokine production to promote the replication of Newcastle disease virus

Meng,

Wang,

Kong

et al. 2024

Poultry Science

View full text Add to dashboard Cite

“…Natural disease exposure experiments usually require the use of seeder animals, allowing the determination of heritability for disease response traits [ 24 , 25 ], despite the potential uncontrolled nature of infections among individuals. Protocols for natural exposure of chickens to pathogenic NDV strains have been developed [ 26 , 27 ] and used on the local chicken ecotypes studied here [ 18 , 19 ]. These natural exposure studies, however, resulted in low mortality, likely because of the protective effects of prior inoculation with the vaccine strain of NDV, despite low remaining antibody levels at the time of the infection, and very low estimates of heritability of NDV response traits [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Genetic Analyses of Response of Local Ghanaian Tanzanian Chicken Ecotypes to a Natural Challenge with Velogenic Newcastle Disease Virus

Walugembe

Naazie²,

Mushi³

et al. 2022

Animals

View full text Add to dashboard Cite

Newcastle disease is a devastating poultry disease that often causes significant economic losses in poultry in the developing countries of Africa, Asia, as well as South and Central America. Velogenic Newcastle disease virus (NDV) outbreaks are associated with high mortalities, which can threaten household livelihoods, especially in the rural areas, and lead to loss of high-quality proteins in the form of meat and eggs, as well as household purchasing power. In this study, we exposed unvaccinated Ghanaian and Tanzanian chickens of six local ecotypes to velogenic NDV strains, measured NDV response traits, sequenced their DNA on a genotyping-by-sequencing platform, and performed variance component analyses. The collected phenotypes included: growth rates (pre- and post-exposure); lesion scores (gross lesion severity) in the trachea, proventriculus, intestine, and cecal tonsils; natural antibody levels; anti-NDV antibody levels at 7 days post exposure (dpe); tear and cloacal viral load at 2, 4, and 6 dpe; and survival time. Heritability estimates were low to moderate, ranging from 0.11 for average lesion scores to 0.36 for pre-exposure growth rate. Heritability estimates for survival time were 0.23 and 0.27 for the Tanzanian and Ghanaian ecotypes, respectively. Similar heritability estimates were observed when data were analyzed either separately or combined for the two countries. Survival time was genetically negatively correlated with lesion scores and with viral load. Results suggested that response to mesogenic or velogenic NDV of these local chicken ecotypes could be improved by selective breeding. Chickens that are more resilient to velogenic NDV can improve household livelihoods in developing countries.

show abstract

Genotypic and phenotypic characterisation of three local chicken ecotypes of Ghana based on principal component analysis and body measurements

Botchway,

Amuzu-Aweh,

Naazie

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

This study aimed to characterise three Ghanaian local chicken ecotypes, namely, Interior Savannah, Forest, and Coastal Savannah, based on morphological data and single nucleotide polymorphism (SNP) genotypes. Morphological data including body weight, shank length, body girth, back length, thigh length, beak length, comb length, and wattle length were collected from 250 local chickens. DNA isolated from blood of 1,440 local chickens was used for SNP genotyping with the Affymetrix chicken 600k SNP chip. Principal component analysis showed that Forest and Coastal Savannah birds were closely related. Generally, all three ecotypes exhibited high genetic diversity, especially birds from the Interior Savannah zone. Morphological characterisation showed that ecotype (p = 0.016) and sex (p = 0.000) had significant effects on body weight. Birds of the Interior Savannah ecotype were the heaviest (p = 0.004), with mean weights of 1.23 kg for females and 1.40 kg for males. Sex also had a strong significant effect on most of the morphological measurements, but the sex * ecotype interaction effect was not significant. Very few of the feather phenotypes previously reported to be associated with heat resistance–frizzle (2%) and naked neck (1.6%)–were found in the studied populations. It is concluded that the three local ecotypes are genetically diverse but with similar morphological features and the information provided would be useful for future selection decisions.

show abstract

Host response to successive challenges with lentogenic and velogenic Newcastle disease virus in local chickens of Ghana

Cited by 3 publications

References 38 publications

Chicken speckle-type POZ protein (SPOP) negatively regulates MyD88/NF-κB signaling pathway mediated proinflammatory cytokine production to promote the replication of Newcastle disease virus

Chicken speckle-type POZ protein (SPOP) negatively regulates MyD88/NF-κB signaling pathway mediated proinflammatory cytokine production to promote the replication of Newcastle disease virus

Genetic Analyses of Response of Local Ghanaian Tanzanian Chicken Ecotypes to a Natural Challenge with Velogenic Newcastle Disease Virus

Genotypic and phenotypic characterisation of three local chicken ecotypes of Ghana based on principal component analysis and body measurements

Contact Info

Product

Resources

About