2011
DOI: 10.1111/j.1600-051x.2010.01682.x
|View full text |Cite
|
Sign up to set email alerts
|

Host‐response: understanding the cellular and molecular mechanisms of host‐microbial interactions – Consensus of the Seventh European Workshop on Periodontology

Abstract: Background: Major challenges in periodontology include understanding the pathophysiology, the interplay between various components of the host response, parallels with other diseases and identifying biomarkers of the disease. Objectives: Four reviews were compiled with the aim of better understanding: (1) the role of polymorphic nuclear leucocytes (PMNs), i.e. neutrophils; (2) the function of cytokine networks in the host response; (3) whether parallels exist with rheumatoid arthritis (RA); and (4) whether use… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

6
147
1
6

Year Published

2012
2012
2022
2022

Publication Types

Select...
8
1
1

Relationship

0
10

Authors

Journals

citations
Cited by 157 publications
(160 citation statements)
references
References 13 publications
6
147
1
6
Order By: Relevance
“…In the context of periodontitis, elevated levels of RANKL and reduced levels of osteoprotegerin (OPG) were detected in the GCF samples of patients with periodontitis and the RANKL/OPG ratio was suggested as a possible biomarker test for detection of bone destruction (Ref. 163). OPG acts as a decoy receptor for RANKL and inhibiting OPG expression enables RANKL to interact with its receptor RANK on other cells.…”
Section: Inflammatory Mediators and Bone Resorptionmentioning
confidence: 99%
“…In the context of periodontitis, elevated levels of RANKL and reduced levels of osteoprotegerin (OPG) were detected in the GCF samples of patients with periodontitis and the RANKL/OPG ratio was suggested as a possible biomarker test for detection of bone destruction (Ref. 163). OPG acts as a decoy receptor for RANKL and inhibiting OPG expression enables RANKL to interact with its receptor RANK on other cells.…”
Section: Inflammatory Mediators and Bone Resorptionmentioning
confidence: 99%
“…Gingivitis is a gingival inflammation without the loss of supporting periodontal tissues, while periodontitis is characterized by impaired attachment and loss of bone (4). Inflammatory biomarkers can provide additional information to disease progression beyond standard clinical and radiographic examinations (5).…”
Section: Introductionmentioning
confidence: 99%
“…About 11% of adults develop clinical periodontitis. The dental plaque is caused by the development of anaerobic bacteria that cause accumulation and activation of neutrophils, which is orchestrated by various mediators and enzymes that destroy the connective tissue [2,3]. Untreated periodontitis ultimately leads to loss of support of the teeth, and atrophy of the alveolar process, causing loss of the teeth.…”
Section: Introductionmentioning
confidence: 99%