Host responses and bacterial colonization following inoculation of Pasteurella multocida P52 strain into unvaccinated and aluminum hydroxide gel hemorrhagic septicemia vaccinated mice

Singh, Mamta; Verma, Rishendra; Pandit, Ramane Sangram; Tarfain, Najeeb Ul

doi:10.1016/j.micpath.2017.09.004

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…It was found that P. multocida B:2 tends to attach to the lung as early as 2 hours post-inoculation with a mild colonization. In natural infection, colonisation and proliferation of P. multocida started in the nasal mucosa before it is inhaled and deposited in the lungs leading to multifocal points of infective sites (Gonzales and Maheswaran, 1993;Singh et al, 2017). This study revealed that the rate of attachment increased to reach peak at 10 hours post-inoculation.…”

Section: Discussionmentioning

confidence: 75%

“…Septicaemia develops rapidly following entrance of the causative agent leading to peracute disease, which is characteristic in natural outbreaks of HS (Annas et al, 2015a). This is due to the wide distribution of the bacterium in the various organs (Sarah et al, 2012;Singh et al, 2017). The possible involvement of urinary tract in transmission of HS was first reported by Annas et al (2014) following detection and isolation of high concentrations of P. multocida B:2 from the kidney, urine and the urinary bladder.…”

Section: Discussionmentioning

confidence: 99%

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In Vitro Attachment and Distribution of Pasteurella multocida B:2 in the Lung and Urinary Bladder of Buffaloes

Puspitasari¹

2018

PVJ

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

In Vitro Attachment and Distribution of Pasteurella multocida B:2 in the Lung and Urinary Bladder of Buffaloes

Puspitasari¹

2018

PVJ

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“…In vitro assays have been performed using macrophages and aortic endothelial cells [348][349][350][351]. Mouse models can play an important role in investigation of pathogenesis and vaccine development [317,[351][352][353][354][355][356][357][358][359][360][361][362][363]. Rats with or without immunosuppression have also been used to explore pathogenesis and novel vaccines [349][350][351][364][365][366].…”

Section: Hemorrhagic Septicemiamentioning

confidence: 99%

Transboundary Animal Diseases, an Overview of 17 Diseases with Potential for Global Spread and Serious Consequences

Clemmons

Alfson

Dutton

2021

Animals

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Animals provide food and other critical resources to most of the global population. As such, diseases of animals can cause dire consequences, especially disease with high rates of morbidity or mortality. Transboundary animal diseases (TADs) are highly contagious or transmissible, epidemic diseases, with the potential to spread rapidly across the globe and the potential to cause substantial socioeconomic and public health consequences. Transboundary animal diseases can threaten the global food supply, reduce the availability of non-food animal products, or cause the loss of human productivity or life. Further, TADs result in socioeconomic consequences from costs of control or preventative measures, and from trade restrictions. A greater understanding of the transmission, spread, and pathogenesis of these diseases is required. Further work is also needed to improve the efficacy and cost of both diagnostics and vaccines. This review aims to give a broad overview of 17 TADs, providing researchers and veterinarians with a current, succinct resource of salient details regarding these significant diseases. For each disease, we provide a synopsis of the disease and its status, species and geographic areas affected, a summary of in vitro or in vivo research models, and when available, information regarding prevention or treatment.

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PamulDB: a comprehensive genomic resource for the study of human- and animal-pathogenic Pasteurella multocida

Tian

et al. 2019

Database

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Pasteurella multocida can infect a wide range of host, including humans and animals of economic importance. Genomics studies on the pathogen have produced a large amount of omics data, which are deposited in GenBank but lacks a dedicated and comprehensive resource for further analysis and integration so that need to be brought together centrally in a coherent and systematic manner. Here we have collected the genomic data for 176 P. multocida strains that are categorized into 11 host groups and 9 serotype groups, and developed the open-access P. multocida Database (PamulDB) to make this resource readily available. The PamulDB implements and integrates Chado for genome data management, Drupal for web content management, and bioinformatics tools like NCBI BLAST, HMMER, PSORTb and OrthoMCL for data analysis. All the P. multocida genomes have been further annotated for search and analysis of homologous sequence, phylogeny, gene ontology, transposon, protein subcellular localization and secreted protein. Transcriptomic data of P. multocida are also selectively adopted for gene expression analysis. The PamulDB has been developing and improving to better aid researchers with identifying and classifying of pathogens, dissecting mechanisms of the pathogen infection and host response.

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Host responses and bacterial colonization following inoculation of Pasteurella multocida P52 strain into unvaccinated and aluminum hydroxide gel hemorrhagic septicemia vaccinated mice

Cited by 3 publications

References 12 publications

In Vitro Attachment and Distribution of Pasteurella multocida B:2 in the Lung and Urinary Bladder of Buffaloes

In Vitro Attachment and Distribution of Pasteurella multocida B:2 in the Lung and Urinary Bladder of Buffaloes

Transboundary Animal Diseases, an Overview of 17 Diseases with Potential for Global Spread and Serious Consequences

PamulDB: a comprehensive genomic resource for the study of human- and animal-pathogenic Pasteurella multocida

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