Hot melt-extrusion improves the properties of cyclodextrin-based poly(pseudo)rotaxanes for transdermal formulation

Marreto, Ricardo Neves; Cardoso, Gleidson; Souza, Bruno dos Santos; Martín-Pastor, Manuel; Cunha-Filho, Marcílio; Taveira, Stephânia Fleury; Concheiro, Angel; Álvarez-Lorenzo, Carmen

doi:10.1016/j.ijpharm.2020.119510

Cited by 30 publications

(26 citation statements)

References 35 publications

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“…HME has been applied using a wide range of polymers in the production of different drug delivery systems, such as tablets [6,7], pellets [8,9], implants [10] and transdermal systems [11,12], but has been especially focused on the production of solid dispersions (SDs) of poorly water-soluble drugs [4]. However, in the last few years, its use in pharmaceutics has been boosted even more due to it being linked to 3D printing processes in the development of innovative medicines.…”

Section: Introductionmentioning

confidence: 99%

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

et al. 2021

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Eudragit® polymers are polymethacrylates highly used in pharmaceutics for the development of modified drug delivery systems. They are widely known due to their versatility with regards to chemical composition, solubility, and swelling properties. Moreover, Eudragit polymers are thermoplastic, and their use has been boosted in some production processes, such as hot melt extrusion (HME) and fused deposition modelling 3D printing, among other 3D printing techniques. Therefore, this review covers the studies using Eudragit polymers in the development of drug delivery systems produced by HME and 3D printing techniques over the last 10 years. Eudragit E has been the most used among them, mostly to formulate immediate release systems or as a taste-masker agent. On the other hand, Eudragit RS and Eudragit L100-55 have mainly been used to produce controlled and delayed release systems, respectively. The use of Eudragit polymers in these processes has frequently been devoted to producing solid dispersions and/or to prepare filaments to be 3D printed in different dosage forms. In this review, we highlight the countless possibilities offered by Eudragit polymers in HME and 3D printing, whether alone or in blends, discussing their prominence in the development of innovative modified drug release systems.

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Section: Introductionmentioning

confidence: 99%

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

et al. 2021

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“…At higher shear rates, the interaction between IBU and SP vanishes due to the strong shear. As a result, the viscosities of both dispersions become similar to that of water, which could explain the system's thixotropic behavior 29 . A hydrophobic drug may also stabilize the micelle through additional hydrophobic interactions between the drug and the hydrophobic part of the micelles 30 .…”

Section: Fig 1: the Particle Size Of Co-polymer And Ibuprofen Co-polymer Nanomieclles At Different Copolymer Concentrations Fig 2: Pdi Ofmentioning

confidence: 88%

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2021

IJPSR

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“…Heat treatments in order to boost dosage stability and enhance the drug's thermodynamic effect on the transdermal membrane. [48][49][50][51][52]…”

Section: Semi-solid Drug Delivery Systemsmentioning

confidence: 99%

Recent Advances in Hot Melt Extrusion and its Applications

KİNİKAR¹,

Kuchekar²

2021

Hacettepe University Journal of the Faculty of Pharmacy

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Over the decades the outcome of industrial compliance, manufacturing process, formulation and development, Hot Melt Extrusion (HME) also expanded the acceptance. As a result of industrial adaptability, it has developed itself into a wide range pharmaceutical research development. New drug entities face failures or delays during formulation development, including poor biopharmaceutical properties toxicity, lack of efficacy, or both. To overcome such obstacles, the HME technique is preferred one. In comparison to conventional techniques, its use is increasing because of its process, solvent free nature, cost effective, and on-line manufacturing. For achieving different applications, several dosage forms can be produced by altering the design of equipment and adapting a modified processing condition.

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Hot melt-extrusion improves the properties of cyclodextrin-based poly(pseudo)rotaxanes for transdermal formulation

Cited by 30 publications

References 35 publications

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

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Recent Advances in Hot Melt Extrusion and its Applications

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