Hot-melt extrusion technique: A novel continuous manufacturing method for enteric-coated pellets

Abstract

The technology of hot-melt extrusion (HME) is becoming a progressively appealing way to develop different drug delivery systems. A wide range of pharmaceutical dosage forms and formulations from oral to topical and parenteral can be prepared. The dosage forms formulated using HME technique are composite mixtures of active pharmaceutical agents, active excipients, and other processing aids. HME has many advantages over traditional techniques of pharmaceutical development, such as non-solvent technology, lower processing requirements, uninterrupted activity, and greater possibility of uniform suspension and increased bioavailability. This paper addresses enteric-coated pellet pharmaceutical applications and its process techniques using the HME technology and its applications in pharmaceutical industries for an efficient pathway for a novel drug delivery system.

Design, Optimization, and Characterization of a Novel Amorphous Solid Dispersion Formulation for Enhancement of Solubility and Dissolution of Ticagrelor

“…Hot-melt extrusion is one of the most efficient and most valued techniques involved for the formulation of solid dispersion. It avoids the use of solvent in the formulation and has maximum scalability [23]. The physical property of the substance under extrusion is altered when the substance is forced through the die or orifice.…”