Hot methanol extract of Leea macrophylla (Roxb.) manages chemical-induced inflammation in rodent model

Hossain, Kazi Helal; Ma, Rahman; Taher, Muhammad; Tangpong, Jitbanjong; Hajjar, Dina; Alelwani, Walla; Makki, Arwa A.; Reza, A. S. M. Ali

doi:10.1016/j.jksus.2020.07.014

Cited by 24 publications

(33 citation statements)

References 19 publications

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“…Carrageenan-induced edema is commonly used as an experimental model for acute inflammation and is proven to be biphasic where carrageenan is known to result in the step-wise discharge of the inflammatory endogenous mediators such as histamine, serotonin, and bradykinin, which are released in the initial phase of the inflammatory response, and prostaglandins, which are released in the late phase. 33,39 After carrageenan application, the paw edema was significantly inhibited at the dose 200 and 400 mg/kg in 1st, 2nd, 3rd and 4th hour where diclofenac Na 100 mg/kg (standard) also inhibited paw edema significantly in 1st, 2nd, 3rd and 4th hour and the 400 mg/kg dose of E. camaldulensis essential oil extract revealed highest 79.23% inhibition among the other dose concentrations.…”

Section: Discussionmentioning

confidence: 95%

“…The formalin-induced pain that was long-lasting and classified into 2 phases as follows: early phase (0, 5 min), formaldehyde directly excites nerve endings; late phase (15, 20 min), inflammatory mediators are produced and released. 33,34 Previous studies verified that bradykinin participates in the first phase, whereas histamine, serotonin, prostaglandins, NO and bradykinin were involved in the second phase of the formalin test. 35 This experimental study showed that the leaf essential oil of E. camaldulensis produced a significant inhibitory effect during the first phase and the second phase of the formalin test.…”

Section: Discussionmentioning

confidence: 99%

“…The formalin-induced hind paw licking response was used as a model for evaluating analgesics. 33 Mice were subcutaneously administered with 20 µL of 2.5% formalin solution (0.9% formaldehyde) on the dorsal part of the mouse hind paw. The formalin-induced pain that was long-lasting and classified into 2 phases as follows: early phase (0, 5 min), formaldehyde directly excites nerve endings; late phase (15, 20 min), inflammatory mediators are produced and released.…”

Section: Discussionmentioning

confidence: 99%

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Analgesic and Anti-Inflammatory Potential of Essential Oil of Eucalyptus camaldulensis Leaf: In Vivo and in Silico Studies

Mondal

Quispe

Sarkar

et al. 2021

Natural Product Communications

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The objective of our present study is to scrutinize the analgesic and anti-inflammatory potentials of essential oil of Eucalyptus camaldulensis leaf using different in vivo assay models at doses of 100, 200, and 400 mg/kg body weight. Twenty chemical compounds, which were isolated from the leaves essential oil of E. camaldulensis, were docked using AutodockVina against cyclooxygenase 2, tumor necrosis factor-α, and interleukin-1β convertase to elucidate the analgesic and anti-inflammatory activity. The essential oil of E. camaldulensis exhibited noteworthy analgesic activities in the writhing test. In the tail immersion and hot-plate test, the essential oil significantly extended the latency period. The number of licks in the formalin-induced paw licking test was markedly reduced following essential oil administration. In addition, E. camaldulensis essential oil revealed notable anti-inflammatory responses in carrageenan-induced paw edema, xylene induced ear edema and cotton pellet induced granuloma methods. Among 20 compounds, 5 ( cis-sabinol, globulol, α-eudesmol, β-eudesmol, and γ-eudesmol) showed better binding for cyclooxygenase-2 while β-eudesmol exhibited higher affinity for TNFα than that of TNF-alpha-IN-1 and standard drug. In the case of interleukin 1β convertase, maximum affinity was shown by α-eudesmol than the synthetic drug belnacasan. Chemical components of the essential oil interacted with diverse amino acid residues which were similar to the natural substrate and standard drugs. In conclusion, E. camaldulensis essential oil can be an effective source of analgesic and anti-inflammatory treatment and additional modification and docking studies will be required to justify the efficiency of globulol, α-eudesmol, β-eudesmol, and γ-eudesmol.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Analgesic and Anti-Inflammatory Potential of Essential Oil of Eucalyptus camaldulensis Leaf: In Vivo and in Silico Studies

Mondal

Quispe

Sarkar

et al. 2021

Natural Product Communications

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“…The bioactive compounds from CHF were analyzed using GC‐MS analysis followed by the method described earlier (Bulbul et al., 2019; Hossain et al., 2020).…”

Section: Methodsmentioning

confidence: 99%

Antiproliferative and antioxidant potentials of bioactive edible vegetable fraction of Achyranthes ferruginea Roxb. in cancer cell line

Reza

Haque

Sarker

et al. 2021

Food Science & Nutrition

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In the present study, the aerial parts of Achyranthes ferruginea underwent investigation of their in vitro antioxidant and free radical‐scavenging activities in cell‐free conditions, their phytoconstituents using gas chromatography‐mass spectrometry (GC‐MS), and their cytotoxic activity in HeLa cells. A. ferruginea was extracted with 80% methanol and successively fractionated with solvents to yield petroleum ether (PEF), chloroform (CHF), ethyl acetate (EAF), and aqueous (AQF) fractions. GC‐MS analysis revealed that CHF contained ten phytoconstituents, including different forms of octadecanoic acid methyl esters. The total antioxidant and ferric‐reducing antioxidant capacities of the extracts and the standard catechin (CA) were as follows: CA >CHF >PEF >CME (crude methanolic extract) >EAF >AQF, and CA >CHF >EAF >PEF >AQF >CME, respectively. CHF showed the highest DPPH‐free radical‐scavenging activity, with a median inhibitory concentration of 10.5 ± 0.28 µg/ml, which was slightly higher than that of the standard butylated hydroxytoluene (12.0 ± 0.09 µg/ml). In the hydroxyl radical‐scavenging assay, CHF showed identical scavenging activity (9.25 ± 0.73 µg/ml) when compared to CA (10.50 ± 1.06 µg/ml). Moreover, CHF showed strong cytotoxic activity (19.95 ± 1.18 µg/ml) in HeLa cells, which was alike to that of the standards vincristine sulfate and 5‐fluorouracil (15.84 ± 1.64 µg/ml and 12.59 ± 1.75 µg/ml, respectively). The in silico study revealed that identified compounds were significantly linked to the targets of various cancer cells and oxidative enzymes. However, online prediction by SwissADME, admetSAR, and PASS showed that it has drug‐like, nontoxic, and potential pharmacological actions.

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“…In developing countries, CAM practice has long been used by local communities as a prime source of their healthcare system to improve a huge number of diseases (Ansari et al, 2017;Hossain et al, 2020;Moni et al, 2021;Rahman et al, 2021). The uses of CAM increased significantly both the developed and developing countries due to its accessibility, affordability, and good perception about safety comparing to conventional medicine.…”

Section: Introductionmentioning

confidence: 99%

Knowledge, Attitude, Perception of Biological Science and Healthcare Professional Students to Complementary and Alternative Medicine Health Belief and Practice in Southeastern Region of Bangladesh: A Comparative Study

et al. 2021

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The health professionals require scientific knowledge to advise their patients on complementary and alternative medicines (CAM). Previously, several studies were conducted regarding the CAM perception, attitude and use on health care professionals only; in contrast, our study encompasses both students of health care professionals and other disciplines. The aim of this study was to compare the attitudes and perception about CAM practices between students of biological sciences (Biochemistry and Molecular Biology, Microbiology and Botany) and health care professionals (Pharmacy and medical students) in public and private universities located in the southeastern region in Bangladesh. The questionnaire-based study conducted on 332 systematically sampled students (four private and one public universities) located in the southeastern region in Bangladesh. The cross-sectional study was conducted from March to July, 2018. All students showed a positive attitude towards CAM use. Herbal medicine, homeopathy, nutritional supplements followed by hypnosis, massage, spiritual healing, and meditation were the most commonly known and used CAM modalities. Most of the students (40.7%) believed that the integration of CAM and conventional medicine should be essential in health care setting. The major obstacles for CAM use are patient interest (48.2%) and lack of physician interest (43.4%). In addition, 36.7% students believed that CAM practices should be included in their school’s curriculum. Moreover, 39.5% students assumed that CAM knowledge is important to their daily life. Biological sciences and healthcare professional students of Bangladesh showed positive perception on CAM uses. Bangladesh Pharmaceutical Journal 24(2): 159-167, 2021

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Hot methanol extract of Leea macrophylla (Roxb.) manages chemical-induced inflammation in rodent model

Cited by 24 publications

References 19 publications

Analgesic and Anti-Inflammatory Potential of Essential Oil of Eucalyptus camaldulensis Leaf: In Vivo and in Silico Studies

Analgesic and Anti-Inflammatory Potential of Essential Oil of Eucalyptus camaldulensis Leaf: In Vivo and in Silico Studies

Antiproliferative and antioxidant potentials of bioactive edible vegetable fraction of Achyranthes ferruginea Roxb. in cancer cell line

Knowledge, Attitude, Perception of Biological Science and Healthcare Professional Students to Complementary and Alternative Medicine Health Belief and Practice in Southeastern Region of Bangladesh: A Comparative Study

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