Hot Spots in Ag Core−Au Shell Nanoparticles Potent for Surface-Enhanced Raman Scattering Studies of Biomolecules

Kumar, G. V. Pavan; Shruthi, S; Vibha, B.; Reddy, B. Ashok; Kundu, Tapas K.; Narayana, Chandrabhas

doi:10.1021/jp068253n

Cited by 164 publications

(111 citation statements)

References 29 publications

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“…Additionally, these spectra show that the LLI does not adversely affect the sensor, as comparisons with literature [40][41][42][43] . In all cases the signal-to-noise ratio and sensitivity is as good (if not better) for these analytes at the LLI.…”

Section: Introductionsupporting

confidence: 71%

Self-assembled nanoparticle arrays for multiphase trace analyte detection

et al. 2012

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Nanoplasmonic structures designed for trace analyte detection by surface enhanced Raman spectroscopy typically require sophisticated nanofabrication techniques. An alternative to fabricating such arrays is to rely on self-assembly of nanoparticles at liquid-liquid or liquid-air interfaces into close-packed arrays.The density of the arrays can be fine tuned by modifying the nanoparticle functionality, pH of the solution, and salt concentration. Importantly, these arrays are robust, "self-healing", reproducible, and extremely easy to handle. Herein, we report on the use of such platforms made of Au nanoparticles for detection of (multi)analytes from the aqueous, organic, or air phases. The total interfacial area of the Au array, at the liquid-liquid interface, is approximately 25 mm 2 , making this platform ideal for small volume samples, low concentrations, and trace analytes. Importantly, the ease of assembly and rapid 2 detection makes this platform ideal for in-field sample testing of toxins such as explosives, drugs, or other hazardous chemicals.3

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Section: Introductionsupporting

confidence: 71%

Self-assembled nanoparticle arrays for multiphase trace analyte detection

et al. 2012

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“…The hot spots in bimetallic coated nanoparticles with pinholes were investigated by means of experimental method [37]. On the theoretical side, the nonlocality should be involved to study the hot spots in the enhancement of Raman signal due to the pinholes or other nano-defects at rather small scale.…”

Section: Resultsmentioning

confidence: 99%

Nonlocal Effects on Surface Enhanced Raman Scattering From Bimetallic Coated Nanoparticles

Huang¹,

Gao²

2013

PIER

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Abstract-We study the surface enhanced Raman scattering (SERS) from bimetallic core-shell nanoparticles by taking into account the nonlocal effect.The Gersten-Nitzan model is applied to investigate SERS from a molecule adsorbed on the nonlocal bimetallic nanoparticle. Numerical results show that there are two enhanced SERS peaks for bimetallic coated nanoparticles, and nonlocal effects will lead to less enhancement and blue-shift of SERS peaks. In addition, unusual resonant electric-field patterns are found in the nonlocal gold core in comparison with those in the local case. Our investigation is helpful for understanding some details of SERS schemes in nano-optics and plasmonics when nonlocal effects are considered.

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“…Because the Fermi level for gold is lower than that for silver, the gold atoms in the core can have a strong electronic effect on the surface silver atoms by charge transfer, causing the surface silver atoms adjacent to the gold core to become more active than the silver atoms in monometallic silver nanoparticles. 26 Therefore, as a SERS-active substrate, Au/Ag core-shell nanoparticles can enhance Raman signals of 4-MBA more effectively than gold nanoparticles and silver nanoparticles.…”

Section: Sers-active Substratementioning

confidence: 99%

Immunoassay for LMP1 in nasopharyngeal tissue based on surface-enhanced Raman scattering

Chen

Zheng²,

Chen³

et al. 2011

IJN

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Background:Previous studies have shown that Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) is closely associated with the occurrence and development of nasopharyngeal carcinoma, and can be used as a tumor marker in screening for the disease. Here we report a new methodology based on highly specific and sensitive surface-enhanced Raman scattering (SERS) technology to detect LMP1 in nasopharyngeal tissue sections directly with no need of tedious procedures as with conventional immunohistochemistry methods. Methods: LMP1-functionalized 4-mercaptobenzoic acid (4-MBA)-labeled Au/Ag core-shell bimetallic nanoparticles were prepared first and then applied for analyzing LMP1 in formalinfixed paraffin-embedded nasopharyngeal tissue sections obtained from 34 cancer patients and 20 healthy controls. SERS spectra were acquired from a 25 × 25 spot square area on each tissue section and used to generate SERS images. Results: Data from SERS spectra and images show that this new SERS-based immunoassay detected LMP1 in formalin-fixed paraffin-embedded nasopharyngeal tissue sections with high sensitivity and specificity. The results from the new LMP1-SERS probe method are superior to those of conventional immunohistochemistry staining for LMP1, and in excellent agreement with those of in situ hybridization for EBV-encoded small RNA (EBER). Conclusion:This new SERS technique has the potential to be developed into a new clinical tool for detection and differential diagnosis of nasopharyngeal carcinoma as well as for predicting metastasis and immune-targeted treatment of nasopharyngeal carcinoma.

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Hot Spots in Ag Core−Au Shell Nanoparticles Potent for Surface-Enhanced Raman Scattering Studies of Biomolecules

Cited by 164 publications

References 29 publications

Self-assembled nanoparticle arrays for multiphase trace analyte detection

Self-assembled nanoparticle arrays for multiphase trace analyte detection

Nonlocal Effects on Surface Enhanced Raman Scattering From Bimetallic Coated Nanoparticles

Immunoassay for LMP1 in nasopharyngeal tissue based on surface-enhanced Raman scattering

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