Household chemical exposures and the risk of canine malignant lymphoma, a model for human non-Hodgkin’s lymphoma

Takashima-Uebelhoer, Biki B.; Barber, Lisa G.; Zagarins, Sofija; Procter-Gray, Elizabeth; Gollenberg, Audra L.; Moore, Antony S.; Bertone‐Johnson, Elizabeth R.

doi:10.1016/j.envres.2011.12.003

Cited by 52 publications

(49 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It should be acknowledged that for most forms of cancer the aetiology is likely to be multifactorial and although genetics are important environmental factors such as chemical exposure [227] and hormonal/metabolic factors have been shown to increase the risk of development of certain tumours. …”

Section: Discussionmentioning

confidence: 99%

Breed-Predispositions to Cancer in Pedigree Dogs

Dobson

2013

ISRN Veterinary Science

260

278

View full text Add to dashboard Cite

Cancer is a common problem in dogs and although all breeds of dog and crossbred dogs may be affected, it is notable that some breeds of pedigree dogs appear to be at increased risk of certain types of cancer suggesting underlying genetic predisposition to cancer susceptibility. Although the aetiology of most cancers is likely to be multifactorial, the limited genetic diversity seen in purebred dogs facilitates genetic linkage or association studies on relatively small populations as compared to humans, and by using newly developed resources, genome-wide association studies in dog breeds are proving to be a powerful tool for unravelling complex disorders. This paper will review the literature on canine breed susceptibility to histiocytic sarcoma, osteosarcoma, haemangiosarcoma, mast cell tumours, lymphoma, melanoma, and mammary tumours including the recent advances in knowledge through molecular genetic, cytogenetic, and genome wide association studies.

show abstract

Section: Discussionmentioning

confidence: 99%

Breed-Predispositions to Cancer in Pedigree Dogs

Dobson

2013

ISRN Veterinary Science

260

278

View full text Add to dashboard Cite

show abstract

“…A recent study [209] found a statistically-significant association between the use of “self-applied insect growth regulators” (OR = 2.7; 95% CI = 1.1–6.8) and canine lymphoma, but specific constituents were not identified. Associations between herbicides were not statistically significant (OR = 1.3; 95% CI = 0.9–1.8).…”

Section: Toxicological Studiesmentioning

confidence: 99%

A Systematic Review of Carcinogenic Outcomes and Potential Mechanisms from Exposure to 2,4-D and MCPA in the Environment

Stackelberg

2013

Journal of Toxicology

View full text Add to dashboard Cite

Chlorophenoxy compounds, particularly 2,4-dichlorophenoxyacetic acid (2,4-D) and 4-chloro-2-methylphenoxy)acetic acid (MCPA), are amongst the most widely used herbicides in the United States for both agricultural and residential applications. Epidemiologic studies suggest that exposure to 2,4-D and MCPA may be associated with increased risk non-Hodgkins lymphoma (NHL), Hodgkin's disease (HD), leukemia, and soft-tissue sarcoma (STS). Toxicological studies in rodents show no evidence of carcinogenicity, and regulatory agencies worldwide consider chlorophenoxies as not likely to be carcinogenic or unclassifiable as to carcinogenicity. This systematic review assembles the available data to evaluate epidemiologic, toxicological, pharmacokinetic, exposure, and biomonitoring studies with respect to key cellular events noted in disease etiology and how those relate to hypothesized modes of action for these constituents to determine the plausibility of an association between exposure to environmentally relevant concentrations of 2,4-D and MCPA and lymphohematopoietic cancers. The combined evidence does not support a genotoxic mode of action. Although plausible hypotheses for other carcinogenic modes of action exist, a comparison of biomonitoring data to oral equivalent doses calculated from bioassay data shows that environmental exposures are not sufficient to support a causal relationship. Genetic polymorphisms exist that are known to increase the risk of developing NHL. The potential interaction between these polymorphisms and exposures to chlorophenoxy compounds, particularly in occupational settings, is largely unknown.

show abstract

“…Lymphoma is common in dogs, and resembles non‐Hodgkin lymphoma in humans. Epidemiologic studies have found significant associations between canine lymphoma and exposure to industrial pollutants, solvents and herbicides, but the role of specific environmental carcinogens in the development of lymphoma in dogs is not clear . GSTT1 activities have been characterized in livers from research beagles, and 12% of these dogs had virtually no GSTT1 protein expression or activity .…”

Section: Introductionmentioning

confidence: 99%

Positive association between a glutathione‐S‐transferase polymorphism and lymphoma in dogs

Ginn

Sacco

Wong

et al. 2012

Vet Comparative Oncology

View full text Add to dashboard Cite

Glutathione-S-transferase enzymes (GSTs) play an important role in the detoxification of environmental carcinogens. Defective GST genotypes are over-represented in human cancers; in particular, low activity GSTT1 genotypes are risk factors for non-Hodgkin lymphoma. We hypothesized that defective GSTT1 genotypes would be associated with lymphoma risk in dogs. To address this, we resequenced the exons, splice junctions, and 3'-UTR of canine GSTT1 in dogs with lymphoma (n = 93) and age-matched unaffected dogs (n = 86). Of 27 canine GSTT1 variants identified, the I2+28 G>A was significantly associated with lymphoma [odds ratio (OR) 6.26, 95% confidence interval (CI), 1.77-22.2], with the AA genotype found in 18.3% of affected dogs but only 3.5% of controls (P = 0.002). This intronic variant was predicted to perturb GSTT1 mRNA splicing, and may increase lymphoma risk by impairing detoxification of environmental chemicals. Confirmation of this finding in a larger population of dogs may support the inclusion of GSTT1 genotyping in epidemiologic studies of canine lymphoma risk.

show abstract

Household chemical exposures and the risk of canine malignant lymphoma, a model for human non-Hodgkin’s lymphoma

Cited by 52 publications

References 22 publications

Breed-Predispositions to Cancer in Pedigree Dogs

Breed-Predispositions to Cancer in Pedigree Dogs

A Systematic Review of Carcinogenic Outcomes and Potential Mechanisms from Exposure to 2,4-D and MCPA in the Environment

Positive association between a glutathione‐S‐transferase polymorphism and lymphoma in dogs

Contact Info

Product

Resources

About