How and Where are Drugs Absorbed?

Bermejo, Marival; González‐Álvarez, Isabel

doi:10.1002/9780470571224.pse038

Cited by 5 publications

(6 citation statements)

References 87 publications

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“…Bioavailability is a measurement of the rate and extent of the active drug that reaches systemic circulation. ( 68 ) Animal bioavailability is an important parameter to consider when preparing new forms of a compound, and studies can be set up in a number of different ways to obtain specific information for development. Species for animal studies can include rodents, rabbits, dogs, pigs, and primates.…”

Section: Physicochemical Property Reviewmentioning

confidence: 99%

Pharmaceutical Cocrystals and Their Physicochemical Properties

Schultheiss¹,

Newman²

2009

Crystal Growth & Design

1,331

967

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Over the last 20 years, the number of publications outlining the advances in design strategies, growing techniques, and characterization of cocrystals has continued to increase significantly within the crystal engineering field. However, only within the last decade have cocrystals found their place in pharmaceuticals, primarily due to their ability to alter physicochemical properties without compromising the structural integrity of the active pharmaceutical ingredient (API) and thus, possibly, the bioactivity. This review article will highlight and discuss the advances made over the last 10 years pertaining to physical and chemical property improvements through pharmaceutical cocrystalline materials and, hopefully, draw closer the fields of crystal engineering and pharmaceutical sciences.

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Section: Physicochemical Property Reviewmentioning

confidence: 99%

Pharmaceutical Cocrystals and Their Physicochemical Properties

Schultheiss¹,

Newman²

2009

Crystal Growth & Design

1,331

967

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“…On the other hand, active transport requires energy to transport the drugs into the cell. Active transport is selective and may involve the transport of drugs against the concentration gradient—for example, from a low concentration side to a high concentration side [109]. Active transport usually occurs with endogenous substances such as vitamins, sugars and amino acids.…”

Section: Dep Applications In Biomedical Sciencesmentioning

confidence: 99%

Dielectrophoresis for Biomedical Sciences Applications: A Review

Rahman

Ibrahim

Yafouz

2017

Sensors

174

155

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Dielectrophoresis (DEP) is a label-free, accurate, fast, low-cost diagnostic technique that uses the principles of polarization and the motion of bioparticles in applied electric fields. This technique has been proven to be beneficial in various fields, including environmental research, polymer research, biosensors, microfluidics, medicine and diagnostics. Biomedical science research is one of the major research areas that could potentially benefit from DEP technology for diverse applications. Nevertheless, many medical science research investigations have yet to benefit from the possibilities offered by DEP. This paper critically reviews the fundamentals, recent progress, current challenges, future directions and potential applications of research investigations in the medical sciences utilizing DEP technique. This review will also act as a guide and reference for medical researchers and scientists to explore and utilize the DEP technique in their research fields.

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“…Here, we report bioanalytical methods to characterize 5-LIO(Me-3,2-HOPO) and 3,4,3-LI(1,2-HOPO) in rat plasma and describe the pharmacokinetics of the free acid and four salt forms of each ligand after a single intravenous (iv) or oral (po) administration in rats. Both APIs are amorphous and poorly soluble in their free acid forms, and little effort had been made to investigate formal crystallization procedures and solid-state characterization, as well as the effect of the solid-state form on the bioavailability of the APIs [11,12]. This work therefore imparted a reproducible analytical method for the pharmacological characterization of 5-LIO(Me-3,2-HOPO) and 3,4,3-LI(1,2-HOPO), and provided the data necessary to select the appropriate solid form of each API for further development, based on bioavailability.…”

Section: Introductionmentioning

confidence: 99%

Analytical Methods for the Bioavailability Evaluation of Hydroxypyridinonate Actinide Decorporation Agents in Pre-Clinical Pharmacokinetic Studies

Chang¹

2013

J Chromat Separation Techniq

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The hydroxypyridinonate ligands 5-LIO(Me-3,2-HOPO) and 3,4,3-LI(1,2-HOPO) are two lead compounds under development for actinide chelation therapy. Methods to quantify these actinide decorporation agents in plasma are necessary to study their in vivo pharmacokinetic behavior. Such bioanalytical methods were developed with rat plasma, using liquid chromatography coupled with tandem mass spectrometry, and have a detection range of 0.05 to 2.5 µg/mL and 0.1 to 5 µg/mL for 5-LIO(Me-3,2-HOPO) and 3,4,3-LI(1,2-HOPO), respectively. These methods were used to determine the in vivo plasma pharmacokinetics of the free acid and four salt forms of each ligand after a single intravenous or oral administration in rats. The different salt forms displayed similar pharmacokinetic profiles to those of the corresponding free acid, and the use of salt co-formers did not improve the oral bioavailability of the active pharmaceutical ingredients in rats. The described bioanalytical detection methods were successfully applied to the selection of solid-state forms of 5-LIO(Me-3,2-HOPO) and 3,4,3-LI(1,2-HOPO) for future preclinical development activities, and will be adapted for use with plasma from other species.

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How and Where are Drugs Absorbed?

Cited by 5 publications

References 87 publications

Pharmaceutical Cocrystals and Their Physicochemical Properties

Pharmaceutical Cocrystals and Their Physicochemical Properties

Dielectrophoresis for Biomedical Sciences Applications: A Review

Analytical Methods for the Bioavailability Evaluation of Hydroxypyridinonate Actinide Decorporation Agents in Pre-Clinical Pharmacokinetic Studies

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