How are different neural networks related to consciousness?

Qin, Pengmin; Wu, Xuehai; Huang, Zirui; Duncan, Niall W.; Tang, Weijun; Wolff, Annemarie; Hu, Jin; Gao, Liang; Jin, Yi; Wu, Xing; Zhang, Jianfeng; Lu, Lu; Wu, Chunping; Qu, Xiaolei; Mao, Ying; Weng, Xuchu; Zhang, Jun; Northoff, Georg

doi:10.1002/ana.24479

Cited by 119 publications

(111 citation statements)

References 53 publications

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“…Here, we advance this approach by assessing covert consciousness using fMRI mental imagery tasks while incrementally titrating the dose of propofol to and beyond loss of overt motor responsiveness. It is noteworthy that patients with VS/UWS and subjects under sedation/anesthesia exhibit some shared alterations of brain activity, such as globally reduced metabolic activity 34–36 , reduced functional connectivity 24,37–42 , and residual stimulus-evoked activities 31–33,43–45 . Therefore, we believe that the use of anesthetics in healthy participants will help accelerate the development of new approaches to detect covert consciousness in a rigorous and reproducible way that is difficult to achieve in the clinical setting for unresponsive patients with heterogeneous neuropathology.…”

Section: Discussionmentioning

confidence: 99%

Brain imaging reveals covert consciousness during behavioral unresponsiveness induced by propofol

Huang

Vlisides

Tarnal

et al. 2018

Sci Rep

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Detecting covert consciousness in behaviorally unresponsive patients by brain imaging is of great interest, but a reproducible model and evidence from independent sources is still lacking. Here we demonstrate the possibility of using general anesthetics in a within-subjects study design to test methods or statistical paradigms of assessing covert consciousness. Using noninvasive neuroimaging in healthy volunteers, we identified a healthy study participant who was able to exhibit the specific fMRI signatures of volitional mental imagery while behaviorally unresponsive due to sedation with propofol. Our findings reveal a novel model that may accelerate the development of new approaches to reproducibly detect covert consciousness, which is difficult to achieve in patients with heterogeneous and sometimes clinically unstable neuropathology.

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Section: Discussionmentioning

confidence: 99%

Brain imaging reveals covert consciousness during behavioral unresponsiveness induced by propofol

Huang

Vlisides

Tarnal

et al. 2018

Sci Rep

Self Cite

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“…the salience network [62]. Acute pain onset (aversion) results in negative activity change in the nucleus accumbens and pain offset (relief) produces positive activity change in the dorsal anterior cingulate cortex and nucleus accumbens.…”

Section: Reconditioning Stimulationmentioning

confidence: 99%

Visions on the future of medical devices in spinal cord stimulation: what medical device is needed?

Ridder

Vanneste

2016

Expert Review of Medical Devices

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Recently burst stimulation and 10 kHz stimulation have been developed as novel stimulation designs. Both appear to be superior to classical tonic stimulation in the amount of responders and the amount of pain suppression and have as an extra advantage that they are paresthesia-free. This evolution is very important as it shifts the focus of research from better targeting by developing new lead configurations to better communication with the nervous system. It can be envisioned that this is only the start of a new trend in spinal cord, brain, and peripheral nerve stimulation and that more new stimulation designs will be developed in the near future such as pseudorandom burst stimulation, pleasure stimulation, noise stimulation and reconditioning stimulation. This evolution mandates a new approach in the development of internal pulse generators, and the most obvious approach is to develop an upgradable stimulator, on which new stimulation designs can be downloaded, analogous to the apps people download on their smartphones. This will create a shift from hardware driven products to software driven stimulators.

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“…Например, к наиболее значимым зонам, уча-ствующим в формировании феномена сознания, отнесе-ны кора лобных и теменных долей, предклинье, ангуляр-ная борозда, таламус. Эти структуры мозга формируют так называемую рабочую сеть сознания [21][22][23]. Детали работы этой сети постоянно дополняются новыми фак-тами.…”

Section: роль фмрт в выявлении сознания у пациентов соответствующих unclassified

“…Если исследуемый пациент находится в сознании, то в состоянии покоя он может погрузиться в какие-либо раз-мышления и воспоминания, в этот момент задействована сеть так называемого внутреннего сознания. Принято считать, что нейрональная «сеть пассивного режима ра-боты мозга», функционирующая при отсутствии внешних стимулов, поддерживается активностью таких структур, как кора лобных и теменных долей, ангулярная борозда, предклинье [21,22]. D. Kondziella и соавт.…”

Section: роль фмрт в выявлении сознания у пациентов соответствующих unclassified

Vegetative State: Difficulty in Identifying Consciousness and Predicting Outcome

Kondratyeva

Avdunina²,

Kondratyev

et al. 2016

Annals RAMS

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Vegetative State: Difficulty in Identifying Consciousness and Predicting Outcome Article consists of literature review, authors experience of the application of neurovisualization and neurophysiological research methods to predict the recovery of consciousness in patients in vegetative state (VS). According to the literature data PET with FDG has higher sensitivity in the detection of signs of consciousness, then functional MRI (fMRI

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How are different neural networks related to consciousness?

Abstract: Our findings show that SN (SACC-LAI) connectivity correlates with behavioral signs of consciousness, whereas DMN (PCC-LLPC) connectivity instead predicts recovery of consciousness.

Cited by 119 publications

References 53 publications

Brain imaging reveals covert consciousness during behavioral unresponsiveness induced by propofol

Brain imaging reveals covert consciousness during behavioral unresponsiveness induced by propofol

Visions on the future of medical devices in spinal cord stimulation: what medical device is needed?

Vegetative State: Difficulty in Identifying Consciousness and Predicting Outcome

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