2006
DOI: 10.1038/sj.jhh.1002004
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How can we block sympathetic overactivity? Effects of rilmenidine and atenolol in overweight hypertensive patients

Abstract: The aim of the present study was to evaluate effects of long-term treatment with rilmenidine compared with atenolol on lipid and glucose metabolism and cardiovascular remodelling in hypertension. In total, 37 patients with hypertension were randomised to rilmenidine 1-2 mg/day or atenolol 50-100 mg/day for 26 weeks. Standard oral glucose tolerance test with a parallel measurement of insulin and glucose levels was performed. The 'areas under the curve' (AUC) for insulin and glucose were calculated. Plasma lipid… Show more

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Cited by 6 publications
(3 citation statements)
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References 45 publications
(36 reference statements)
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“…A block randomization method with block sizes of 4 and 6 was used for participant randomization. The area under the curve for glucose and insulin were calculated according to Seltzer’s methods as published elsewhere [18,19]. The homeostasis model assessment of insulin resistance (HOMA-IR) was calculated as follows: fasting insulin (μU/ml) × fasting glucose (mg/dl) ÷ 450.…”
Section: Methodsmentioning
confidence: 99%
“…A block randomization method with block sizes of 4 and 6 was used for participant randomization. The area under the curve for glucose and insulin were calculated according to Seltzer’s methods as published elsewhere [18,19]. The homeostasis model assessment of insulin resistance (HOMA-IR) was calculated as follows: fasting insulin (μU/ml) × fasting glucose (mg/dl) ÷ 450.…”
Section: Methodsmentioning
confidence: 99%
“…[14][15] Other relationships to adrenergic function, such as age, heredity, concomitant drug therapies and so on, will also need to be considered in any study. [16][17][18] In conclusion, the study by Bakris et al provides new interesting information on the favourable blood pressure lowering effects of microvascular decompression caused by chiropractic procedure. Before recommending this therapeutic strategy in the current clinical practice, however, it seems reasonable to wait for the results of large-scale clinical trials aimed at defining the long-term effects of the intention on clinic and ambulatory blood pressure as well as on some surrogate end points, such as cardiac and vascular target organ damage.…”
mentioning
confidence: 88%
“…From the available therapeutic arsenal to treat sympathetic overactivity-linked hypertension [22], the centrally acting antihypertensive drugs capable of reducing autonomic imbalance seem preferable. Clonidine (CL) and Rilmenidine (RI) are among the most prescribed centrally acting sympatholytic molecules [23][24][25].…”
Section: Introductionmentioning
confidence: 99%