How Common Are the “Common” Neurologic Disorders?

Hirtz, Deborah; Thurman, David J.; Gwinn-Hardy, Katrina; Mohamed, Mohtadi Mohamoud; Chaudhuri, Arindam; Zalutsky, Robert

doi:10.1212/01.wnl.0000278071.91524.4d

Cited by 383 publications

(18 citation statements)

References 259 publications

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“…6 These findings are also present in other studies, which reported a female predominance in the diagnosis of Headache and a higher peak of incidence of tension headache and migraine (the two main representatives of this group of diseases) between 20 and 40 years of age. 11,14 In addition to other factors such as age and regional characteristics, possibly the majority of women in our sample justifies the high frequency of Headache found in our study.…”

Section: Discussionsupporting

confidence: 58%

The main neurologic diagnoses from a neurology outpatient clinic in Rio de Janeiro, Brazil

et al. 2019

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This study aims to evaluate the prevalence, distribution and clinical profile of neurological diseases and syndromes from a neurology outpatient clinic in the city of Rio de Janeiro. This is a quantitative, cross-sectional study. 180 medical records of firsttime visits conducted through 18 months were analyzed. Age, gender and comorbidities were collected to identify the sample’s profile and the neurological diagnoses found were classified in predefined groups of syndromes according to the ICD-10 classification, which were further stratified according to age and gender. 157 (87,2%) of the patients had a neurological disease, of which the mean age was 51,05 years and 67,5% were women. The most frequent comorbidities were: hypertension (55,6%); dyslipidemia (20,4%); and diabetes (14,6%). The most common neurological diseases were: Sequelae of Cerebrovascular Disease (12,7%); Unspecified Dementia (8,9%); and Migraine without Aura (7,6%). The main neurological syndromes were: Headache (24,8%); Dementia (15,9%); Cerebrovascular Disease (13,4%); Movement Disorders (12,1%); and Radiculopathy (10,8%). The age and gender profile of these syndromes was further described. These data contribute to better understand the distribution of neurological diseases in the neurological outpatient setting.

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Section: Discussionsupporting

confidence: 58%

The main neurologic diagnoses from a neurology outpatient clinic in Rio de Janeiro, Brazil

et al. 2019

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“…By conservative estimates, 400,000 people live with MS in the United States today [1] and over 2.5 million people live with MS worldwide [2]. Each year, approximately 16,000 veterans with MS receive healthcare services from the Veterans Health Administration (VHA).…”

Section: Introductionmentioning

confidence: 99%

Falls requiring medical attention among veterans with multiple sclerosis: A cohort study

Cameron

Poel

Haselkorn

et al. 2011

JRRD

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Abstract-The purpose of this study was to estimate the relative risk of an injurious fall requiring medical attention in veterans with multiple sclerosis (MS) compared with veterans without MS after controlling for sex, age, and healthcare use. The sample included 195,417 veterans treated at Veterans Health Administration (VHA) facilities in the Northwest United States in fiscal year 2008. We obtained information regarding MS diagnosis, injurious falls (operationalized as International Classification of Diseases-9th Revision-Clinical Modification codes E880-E888), and demographic and healthcare use data from the VHA Consumer Health Information Performance Set database. Using logistic regression, we determined the adjusted odds ratio (OR) of an injurious fall to be three times higher in female veterans with MS than in female veterans without MS (OR = 3.0, 95% confidence interval [CI] = 1.6-5.5). The adjusted OR of an injurious fall for men with MS was also higher than for men without MS, but this difference was not statistically significant (OR = 1.2, 95% CI = 0.8-2.1). We recommend further studies evaluating the medical, social, and economic consequences of injurious falls, as well as interventions to prevent injurious falls, to improve the independence and quality of life of veterans and others living with MS.

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“…Neurodegenerative disorders are common and age-related. For example, there are 65 AD patients and 9.5 PD patients per 1000 elderly people in the United States, while the annual incidence of ALS is 1.6 [ 45 ]. There is much evidence that oxidative damage is involved in the pathogenesis of neurodegenerative disorders, including AD and PD [ 46 ].…”

Section: Relationship Between Rna Oxidation and Neurodegenerative mentioning

confidence: 99%

Role of RNA Oxidation in Neurodegenerative Diseases

Liu

Chen

et al. 2020

IJMS

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In the history of nucleic acid research, DNA has always been the main research focus. After the sketch of the human genome was completed in 2000, RNA has been started to gain more attention due to its abundancies in the cell and its essential role in cellular physiology and pathologies. Recent studies have shown that RNAs are susceptible to oxidative damage and oxidized RNA is able to break the RNA strand, and affect the protein synthesis, which can lead to cell degradation and cell death. Studies have shown that RNA oxidation is one of the early events in the formation and development of neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. However, its molecular mechanism, as well as its impact on these diseases, are still unclear. In this article, we review the different types of RNA oxidative damage and the neurodegenerative diseases that are reported to be associated with RNA oxidative damage. In addition, we discuss recent findings on the association between RNA oxidative damage and the development of neurodegenerative diseases, which will have great significance for the development of novel strategies for the prevention and treatment of these diseases.

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How Common Are the “Common” Neurologic Disorders?

Abstract: Objective: To estimate the current incidence and prevalence in the United States of 12 neurologic disorders.

Cited by 383 publications

References 259 publications

The main neurologic diagnoses from a neurology outpatient clinic in Rio de Janeiro, Brazil

The main neurologic diagnoses from a neurology outpatient clinic in Rio de Janeiro, Brazil

Falls requiring medical attention among veterans with multiple sclerosis: A cohort study

Role of RNA Oxidation in Neurodegenerative Diseases

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