How does carrageenan cause colitis? A review

Guo, Juanjuan; Shang, Xuke; Chen, Peilin; Huang, Xiaozhou

doi:10.1016/j.carbpol.2022.120374

Cited by 15 publications

(4 citation statements)

References 103 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Animal studies have demonstrated that pectin and partially hydrolyzed guar gum have the potential in alleviating colitis (Fan et al., 2020; Naito et al., 2006). However, carrageenan has been reported to aggravate colitis in mice in some studies (Guo et al., 2022; Wu et al., 2022). The impact of these polysaccharides on colitis may be associated with their structural modulation of the microbiota.…”

Section: Discussionmentioning

confidence: 99%

In vitro assessment of the effect of four polysaccharides on intestinal bacteria of mice with colitis

et al. 2023

View full text Add to dashboard Cite

Polysaccharides are typically resistant to digestion in the gastrointestinal tract and are instead degraded by gut microbiota in the colon. As such, they are commonly employed as carriers for colon‐targeted drugs, with the potential to regulate gut microbiota. Pectin, carrageenan, guar gum, and xanthan gum are commonly used polysaccharide carriers, but their degradation in the gut microbiota under colitis conditions as well as their effects on gut microbiota remains unclear. In this study, we performed the in vitro fermentation of these four polysaccharides using colonic content microbiota from mice with colitis and evaluated the degree of polysaccharide degradation and the effects on pH, short‐chain fatty acids, and gut microbiota. Our findings indicate that pectin and guar gum had a greater degree of degradation and promoted the production of butyrate, inhibited the proliferation of harmful bacteria (e.g., Enterobacteriaceae), and increased beneficial bacteria (e.g., Bifidobacterium). In contrast, carrageenan and xanthan gum promote the proliferation of Enterobacteriaceae. These results provide theoretical guidance for the selection of drug delivery carriers for inflammatory bowel disease treatment and provide information on the relationship between polysaccharides and gut microbiota.

show abstract

Section: Discussionmentioning

confidence: 99%

In vitro assessment of the effect of four polysaccharides on intestinal bacteria of mice with colitis

et al. 2023

View full text Add to dashboard Cite

show abstract

“…While prior research mainly concentrated on organic sulfur compounds from dietary proteins, the role of inorganic sulfur (SO 4 2− ) remains understudied 20,39 . Carrageenan, a common sulfated polysaccharide food additive, is linked to UC relapse risk and can induce intestinal in ammation in animal model 40,41 . We hypothesized that gut microbiota-mediated carrageenan degradation and subsequent H 2 S production might contribute to its pro-colitis effects.…”

Section: Bacterial Assimilatory Sulfate Reduction Modulates Epithelia...mentioning

confidence: 99%

Microbial Assimilatory Sulfate Reduction-Mediated H2S: An Overlooked Role in Crohn's Disease Development

Luo,

Zhao,

Dwidar

et al. 2024

Preprint

View full text Add to dashboard Cite

Background H2S imbalances in the intestinal tract trigger Crohn's disease (CD), a chronic inflammatory gastrointestinal disorder characterized by microbiota dysbiosis and barrier dysfunction. However, a comprehensive understanding of H2S generation in the gut, and the contributions of both microbiota and host to systemic H2S levels in CD, remain to be elucidated. This investigation aimed to enhance comprehension regarding the sulfidogenic potential of both the human host and the gut microbiota. Results Our analysis of a treatment-naive CD cohorts' fecal metagenomic and biopsy metatranscriptomic data revealed reduced expression of host endogenous H2S generation genes alongside increased abundance of microbial exogenous H2S production genes in correlation with CD. While prior studies focused on microbial H2S production via dissimilatory sulfite reductases, our metagenomic analysis suggests the assimilatory sulfate reduction (ASR) pathway is a more significant contributor in the human gut, given its high prevalence and abundance. Subsequently, we validated our hypothesis experimentally by generating ASR-deficient E. coli mutants ∆cysJ and ∆cysM through the deletion of sulfite reductase and L-cysteine synthase genes. This alteration significantly affected bacterial sulfidogenic capacity, colon epithelial cell viability, and colonic mucin sulfation, ultimately leading to colitis in murine model. Further study revealed that gut microbiota degrade sulfopolysaccharides and assimilate sulfate to produce H2S via the ASR pathway, highlighting the role of sulfopolysaccharides in colitis and cautioning against their use as food additives. Conclusions Our study significantly advances understanding of microbial sulfur metabolism in the human gut, elucidating the complex interplay between diet, gut microbiota, and host sulfur metabolism. We highlight the microbial ASR pathway as an overlooked endogenous H2S producer and a potential therapeutic target for managing CD.

show abstract

“…Polymer materials are often classified as natural polymers and synthetic polymers. Natural polymers generally show good hydrophilicity, and degradability, including a wide range of natural macromolecules such as cellulose, [ 7 ] sodium alginate, [ 8 ] carrageenan, [ 9 ] polyaspartic acid, [ 10 ] and chitosan. [ 11 ] In contrast, synthetic polymers with well‐designed and precise molecular structures often show excellent mechanical properties, special electrical conductivity, excellent ion transport capacity, and remarkable stability.…”

Section: Introductionmentioning

confidence: 99%

Polymers for Aqueous Zinc‐Ion Batteries: From Fundamental to Applications Across Core Components

Niu,

Wang,

Guo

et al. 2024

Advanced Energy Materials

View full text Add to dashboard Cite

Aqueous zinc‐ion batteries (AZIBs) comprising zinc anodes hold intrinsic safety and high energy density ideally for distributed and large‐scale energy storage, thus have generated intriguing properties and increasing research interests. Unlike organic batteries, AZIBs require different, sometimes even opposite design principles and preparation strategies in solvent, electrolyte, and separator. This is especially true for the polymer materials that are widely used as critical components in stabilizing metal anodes and functioning as high‐performance safe cathode materials. This review discusses the explicit compositional and structural requisite of polymeric components in AZIBs, with an emphasis on the exclusive molecular structure–property relationship that governs the stability, reversibility, and capacity of these devices. The usage of polymers is classified into five categories aligning with the primary architecture of AZIBs: separators, additives, hydrogel electrolytes, coatings, and electrode materials. The most recent advances in the structure/property interplay of polymers by novel synthesis and preparation techniques targeting stable AZIBs are summarized and discussed. The challenges and perspectives of multifunctional polymers in developing high‐performance AZIBs are also proposed.

show abstract

How does carrageenan cause colitis? A review

Cited by 15 publications

References 103 publications

In vitro assessment of the effect of four polysaccharides on intestinal bacteria of mice with colitis

In vitro assessment of the effect of four polysaccharides on intestinal bacteria of mice with colitis

Microbial Assimilatory Sulfate Reduction-Mediated H2S: An Overlooked Role in Crohn's Disease Development

Polymers for Aqueous Zinc‐Ion Batteries: From Fundamental to Applications Across Core Components

Contact Info

Product

Resources

About