How does Dielectrophoresis Differ from Electrophoresis?

doi:10.1002/9781118671443.ch2

Cited by 8 publications

(3 citation statements)

References 21 publications

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“…There are alternative isolation methods which not only offer improved performances but are more suited to POCT for CVD diagnostics. Dielectrophoresis (DEP), for instance, is a technique that enables controlled manipulation of particles in a fluid and can separate particles based on their dielectric properties, shape, size and the properties of the surrounding fluid using a non-uniform electrical field to induce a dipole moment in the targeted particles ( Pethig, 2017 ). Moreover, it is ideally suited to separate EVs from bodily fluid samples and is widely utilised in a variety of microfluidic devices ( Zhang et al, 2019a ) and rapidly isolates exosomes from conditioned cell culture media, plasma, serum and urine in 20 min ( Shi et al, 2019 ).…”

Section: Exosome Detection For Cardiovascular Disease Diagnosticsmentioning

confidence: 99%

Exosomal Composition, Biogenesis and Profiling Using Point-of-Care Diagnostics—Implications for Cardiovascular Disease

Burtenshaw

Regan

Owen

et al. 2022

Front. Cell Dev. Biol.

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Arteriosclerosis is an important age-dependent disease that encompasses atherosclerosis, in-stent restenosis (ISR), pulmonary hypertension, autologous bypass grafting and transplant arteriosclerosis. Endothelial dysfunction and the proliferation of vascular smooth muscle cell (vSMC)-like cells is a critical event in the pathology of arteriosclerotic disease leading to intimal-medial thickening (IMT), lipid retention and vessel remodelling. An important aspect in guiding clinical decision-making is the detection of biomarkers of subclinical arteriosclerosis and early cardiovascular risk. Crucially, relevant biomarkers need to be good indicators of injury which change in their circulating concentrations or structure, signalling functional disturbances. Extracellular vesicles (EVs) are nanosized membraneous vesicles secreted by cells that contain numerous bioactive molecules and act as a means of intercellular communication between different cell populations to maintain tissue homeostasis, gene regulation in recipient cells and the adaptive response to stress. This review will focus on the emerging field of EV research in cardiovascular disease (CVD) and discuss how key EV signatures in liquid biopsies may act as early pathological indicators of adaptive lesion formation and arteriosclerotic disease progression. EV profiling has the potential to provide important clinical information to complement current cardiovascular diagnostic platforms that indicate or predict myocardial injury. Finally, the development of fitting devices to enable rapid and/or high-throughput exosomal analysis that require adapted processing procedures will be evaluated.

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Section: Exosome Detection For Cardiovascular Disease Diagnosticsmentioning

confidence: 99%

Exosomal Composition, Biogenesis and Profiling Using Point-of-Care Diagnostics—Implications for Cardiovascular Disease

Burtenshaw

Regan

Owen

et al. 2022

Front. Cell Dev. Biol.

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“…However, when the electric field is nonuniform, the Coulomb forces on the particle edges are not equal hence the particle will carry a net force (Lewpiriyawong & Yang, 2014). Consequently, dielectrophoretic force will rise and the particle will move (Pethig, 2017b). The time-averaged DEP force experienced by a spherical particle in an inhomogeneous electric field is given as (Wei et al, 2009;Zhang et al, 2019):…”

Section: Theorymentioning

confidence: 99%

“…Several reviews have explained the mathematical and numerical models for particles polarization, and for calculation of the DEP force acting on spherical and non-spherical, biological and non-biological particles. The reader is referred to these reviews for more thorough explanation (Jubery et al, 2014;Pethig, 2010Pethig, , 2013Pethig, , 2017bH. Zhao, 2011).…”

Section: Theorymentioning

confidence: 99%

Harvesting of Chlorella sp. microalgae by dielectrophoretic force using titanium dioxide (TiO2) insulated electrodes

et al. 2022

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Roll‐to‐Roll (R2R) Production of Large‐Area High‐Performance Piezoelectric Films Based on Vertically Aligned Nanocolumn Forests

Yildirim

Grant

Es‐haghi

et al. 2020

Adv Materials Technologies

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The recent advances in flexible piezoelectric technologies have sparked a great interest in developing multifunctional next‐generation transducers, which are in high demand for various challenging applications. Here, novel quasi 1–3 piezoelectric films with record‐high piezoelectric voltage coefficients (g33), reaching up to 0.709 Vm N−1, ≈20% greater than the recently reported highest g33 value in the literature, are reported. These composites are constructed via dielectrophoretic alignment of lead zirconate titanate (PZT) particles enhanced by graphene nanoplatelets, leading to densely structured cone‐shaped nanocolumn forests in the thickness direction. To demonstrate its potential applications, both structured and randomly dispersed samples are characterized and used in various applications ranging from energy harvesting to structural and personal health monitoring. Furthermore, when placed on the sensor surface, the oriented piezoelectric films are shown to detect even the slight movements of a small‐sized insect, demonstrating the ultrasensitivity of the system. Finally, to show the scalability of the dielectrophoretic process, a large area sample (12 ft long and 6‐in.‐wide) is also produced continuously via a novel multifunctional custom designed roll‐to‐roll manufacturing line. To the best of the knowledge, this is the largest single piece of piezoelectric film ever reported in the literature.

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How does Dielectrophoresis Differ from Electrophoresis?

Cited by 8 publications

References 21 publications

Exosomal Composition, Biogenesis and Profiling Using Point-of-Care Diagnostics—Implications for Cardiovascular Disease

Exosomal Composition, Biogenesis and Profiling Using Point-of-Care Diagnostics—Implications for Cardiovascular Disease

Harvesting of Chlorella sp. microalgae by dielectrophoretic force using titanium dioxide (TiO2) insulated electrodes

Roll‐to‐Roll (R2R) Production of Large‐Area High‐Performance Piezoelectric Films Based on Vertically Aligned Nanocolumn Forests

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