How does Reelin signaling regulate the neuronal cytoskeleton during migration?

Chai, Xuejun; Frotscher, Michael

doi:10.1080/23262133.2016.1242455

Cited by 33 publications

(32 citation statements)

References 109 publications

(166 reference statements)

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“…Reelin is an extracellular matrix protein synthesized by Cajal-Retzius cells. Reelin signaling is reported to regulate microtubule dynamics by binding to ApoER2 receptors and inhibiting GSK-3β activity, which is known to be an important phosphatase of tau (Chai and Frotscher, 2016). In our study, there was no difference on reelin protein and mRNA levels at each time point after reperfusion between Sham group and CIR group, which is in accordance with the recent study (Lane-Donovan et al, 2016).…”

supporting

confidence: 92%

RETRACTED: Sanhua Decoction, a Classic Herbal Prescription, Exerts Neuroprotection Through Regulating Phosphorylated Tau Level and Promoting Adult Endogenous Neurogenesis After Cerebral Ischemia/Reperfusion Injury

Shi

et al. 2020

Front. Physiol.

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Background: Ischemia stroke is the leading cause of death and long-term disability. Sanhua Decoction (SHD), a classic Chinese herbal prescription, has been used for ischemic stroke for about thousands of years. Here, we aim to investigate the neuroprotective effects of SHD on cerebral ischemia/reperfusion (CIR) injury rat models. Methods: The male Sprague-Dawley rats (body weight, 250-280 g; age, 7-8 weeks) were randomly divided into sham group, CIR group, and SHD group and were further divided into subgroups according to different time points at 6 h, 1, 3, 7, 14, 21, and 28 d, respectively. The SHD group received intragastric administration of SHD at 10 g kg −1 d −1. The focal CIR models were induced by middle cerebral artery occlusion according to Longa's method, while sham group had the same operation without suture insertion. Neurological deficit score (NDS) was evaluated using the Longa's scale. BrdU, doublecortin (DCX), and glial fibrillary acidic protein (GFAP) were used to label proliferation, migration, and differentiation of nerve cells before being observed by immunofluorescence. The expression of reelin, total tau (t-tau), and phosphorylated tau (p-tau) were evaluated by western blot and RT-qPCR. Results: SHD can significantly improve NDS at 1, 3, 7, and 14 d (p < 0.05), increase the number of BrdU positive and BrdU/DCX positive cells in subventricular zone at 3, 7, and 14 d (p < 0.05), upregulate BrdU/GFAP positive cells in the ischemic penumbra at 28 d after CIR (p < 0.05), and reduce p-tau level at 1, 3, 7, and 14 d (p < 0.05). There was no significant difference on reelin and t-tau level between three groups at each time points after CIR. Conclusions: SHD exerts neuroprotection probably by regulating p-tau level and promoting the proliferation, migration, and differentiation of endogenous neural stem cells, accompanying with neurobehavioral recovery.

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confidence: 92%

RETRACTED: Sanhua Decoction, a Classic Herbal Prescription, Exerts Neuroprotection Through Regulating Phosphorylated Tau Level and Promoting Adult Endogenous Neurogenesis After Cerebral Ischemia/Reperfusion Injury

Shi

et al. 2020

Front. Physiol.

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“…In the developing brain, Reelin regulates neuronal migration via control of cell adhesion and cytoskeletal organization ( Sekine et al. 2014 ; Chai and Frotscher 2016 ). In the postnatal brain, Reelin is secreted by interneurons and it specifies CA1 pyramidal cell maturation ( Kupferman et al.…”

Section: Emerging Role Of the Cytoskeleton In Seizure Activity In Thementioning

confidence: 99%

Postnatal Role of the Cytoskeleton in Adult Epileptogenesis

Gavrilovici

Jiang

Kiroski

et al. 2020

Cerebral Cortex Communications

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Mutations in cytoskeletal proteins can cause early infantile and childhood epilepsies by misplacing newly born neurons and altering neuronal connectivity. In the adult epileptic brain, cytoskeletal disruption is often viewed as being secondary to aberrant neuronal activity and/or death, and hence simply representing an epiphenomenon. Here, we review the emerging evidence collected in animal models and human studies implicating the cytoskeleton as a potential causative factor in adult epileptogenesis. Based on the emerging evidence, we propose that cytoskeletal disruption may be an important pathogenic mechanism in the mature epileptic brain.

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“…Neurons extend dendrites into the CP, which requires elongator to acetylate α-tubulin resulting in microtubule reassembly (Creppe et al, 2009 ; Heng et al, 2010 ). Interaction between reelin and VLDLR and ApoER2 causes Dab1 phosphorylation, which recruits PI3K and Lis1 (Bock et al, 2003 ; Chai and Frotscher, 2016 ; Lane-Donovan and Herz, 2017 ). Nectin1 and Nectin3 show capability of facilitating and mediating somal translocation (Hirota and Nakajima, 2017 ; Figure 5 ).…”

Section: Cortical Developmentmentioning

confidence: 99%

Estradiol and the Development of the Cerebral Cortex: An Unexpected Role?

Denley¹,

Gatford²,

Sellers³

et al. 2018

Front. Neurosci.

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The cerebral cortex undergoes rapid folding in an “inside-outside” manner during embryonic development resulting in the establishment of six discrete cortical layers. This unique cytoarchitecture occurs via the coordinated processes of neurogenesis and cell migration. In addition, these processes are fine-tuned by a number of extracellular cues, which exert their effects by regulating intracellular signaling pathways. Interestingly, multiple brain regions have been shown to develop in a sexually dimorphic manner. In many cases, estrogens have been demonstrated to play an integral role in mediating these sexual dimorphisms in both males and females. Indeed, 17β-estradiol, the main biologically active estrogen, plays a critical organizational role during early brain development and has been shown to be pivotal in the sexually dimorphic development and regulation of the neural circuitry underlying sex-typical and socio-aggressive behaviors in males and females. However, whether and how estrogens, and 17β-estradiol in particular, regulate the development of the cerebral cortex is less well understood. In this review, we outline the evidence that estrogens are not only present but are engaged and regulate molecular machinery required for the fine-tuning of processes central to the cortex. We discuss how estrogens are thought to regulate the function of key molecular players and signaling pathways involved in corticogenesis, and where possible, highlight if these processes are sexually dimorphic. Collectively, we hope this review highlights the need to consider how estrogens may influence the development of brain regions directly involved in the sex-typical and socio-aggressive behaviors as well as development of sexually dimorphic regions such as the cerebral cortex.

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How does Reelin signaling regulate the neuronal cytoskeleton during migration?

Cited by 33 publications

References 109 publications

RETRACTED: Sanhua Decoction, a Classic Herbal Prescription, Exerts Neuroprotection Through Regulating Phosphorylated Tau Level and Promoting Adult Endogenous Neurogenesis After Cerebral Ischemia/Reperfusion Injury

RETRACTED: Sanhua Decoction, a Classic Herbal Prescription, Exerts Neuroprotection Through Regulating Phosphorylated Tau Level and Promoting Adult Endogenous Neurogenesis After Cerebral Ischemia/Reperfusion Injury

Postnatal Role of the Cytoskeleton in Adult Epileptogenesis

Estradiol and the Development of the Cerebral Cortex: An Unexpected Role?

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