How Does Vaccination against SARS-CoV-2 Affect Hospitalized Patients with COVID-19?

Moreno-Nunez, Paloma; Bueno‐Cavanillas, Aurora; Jose-Saras, Diego San; Vicente-Guijarro, Jorge; Chávez, Abelardo Claudio Fernández; Aranaz-Andrés, Jesús María

doi:10.3390/jcm11133905

Cited by 5 publications

(1 citation statement)

References 17 publications

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“…The findings of the present study showed that the mortality rate in patients hospitalized in the care units for Corona patients decreased after the start of general vaccination for COVID-19. The results of the study by R. Kempker et al (2022) [ 36 ] and the results of the study by P. Moreno-Nunez et al (2022) [ 37 ] are in line with this finding of the present study. The results of their study showed that the start of general vaccination for COVID-19 was associated with a decrease in mortality in patients hospitalized in COVID-19 wards.…”

Section: Discussionsupporting

confidence: 92%

Investigating the trend of demographic changes, mortality, clinical and paraclinical findings of patients hospitalized in the Corona ward, before and after the start of general vaccination of COVID-19

Morovatshoar,

Hushmandi,

Orouei

et al. 2024

BMC Infect Dis

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Background Prioritizing prevention over treatment has been a longstanding principle in the world health system. This study aims to compare the demographic changes, mortality, clinical, and paraclinical findings of patients hospitalized in the Corona ward before and after the start of general vaccination. Methods This cross-sectional study utilized the simple random sampling method in 2022, analyzing 300 medical records of patients admitted to the Corona ward at 22 Bahman Khaf Hospital. Data were collected using a checklist with the help of the Medical Care Monitoring System and analyzed using SPSS-22 statistical software and Chi-square statistical test at a significance level of p < 0.05. Results Before the start of general vaccination for COVID-19, the majority of patients were hospitalized in the Corona Intensive Care Unit (59.3%), aged between 51 and 65 years (47.3%), hospitalized for more than 3 days (54%), required intubation (49.3%), had SPO2 < 93% (60.7%), and exhibited common symptoms such as cough, shortness of breath, and loss of consciousness. Paraclinical findings included positive CRP, decreased lymphocytes, and ground glass opacity (GGO). After the start of general vaccination for COVID-19, most patients were hospitalized in the general care department of Corona (68%), aged between 36 and 50 years (47.3%), hospitalized for less than three days (66%), required intubation (20%), had SPO2 ≥ 93% (77.3%), and exhibited common symptoms such as weakness, headache, and body pain. Paraclinical findings were within the normal range. Conclusions General vaccination for COVID-19 has significantly reduced patient mortality and morbidity. Health policymakers should prioritize general vaccination to achieve herd immunity and improve public health.

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Section: Discussionsupporting

confidence: 92%

Investigating the trend of demographic changes, mortality, clinical and paraclinical findings of patients hospitalized in the Corona ward, before and after the start of general vaccination of COVID-19

Morovatshoar,

Hushmandi,

Orouei

et al. 2024

BMC Infect Dis

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Vaccination significantly reduced the length of SARS-CoV-2 viral clearance: A story from international healthcare workers

Wang,

Cheng,

Chen

et al. 2024

Journal of Investigative Medicine

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To investigate the impact of vaccine on socio-demographic characteristics, clinical profiles, and outcomes of SARS-CoV-2 infection among healthcare workers in south China during the period of Omicron variant dominance, a retrospective, analytical cross-sectional study was conducted. The findings revealed that while fully vaccination could not prevent Omicron variant infection efficiently (26.51% uninfected vs 14.29% uninfected between vaccinated and unvaccinated participants, p=0.506), it did substantially reduce the length of viral clearance significantly (p<0.05), potentially facilitating quicker patient recovery. Unvaccination was found to be an independent risk factor for slow clearance when a linear regression analysis model was used (Coefficient: -3.516; 95% CI: -6.425~-0.607; p=0.020). Therefore, all eligible individuals should be fully vaccinated to get prepared for potential wave of epidemic in the future.

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Assessing the impact of vaccines on COVID-19 efficacy in survival rates: a survival analysis approach for clinical decision support

González Rodríguez,

Oprescu,

Muñoz Lezcano

et al. 2024

Front. Public Health

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BackgroundThe global COVID-19 pandemic, caused by the SARS-CoV-2 virus, has presented significant challenges to healthcare systems worldwide.ObjectiveThis study, based on an analysis of a cohort from the Public Health System of Andalusia (Spain), aims to evaluate how vaccination affects case-fatality rate in patients hospitalized due to COVID-19 infection in Andalusia.MethodsThe cohort consists of 37,274 individuals after applying the inclusion criteria. We conducted survival analyses employing the Cox proportional hazards models and generated adjusted survival curves to examine the outcomes. The analyses were performed from three perspectives: vaccinated vs. unvaccinated patients, vaccinated and unvaccinated patients grouped by age, and stratified by vaccination status.ResultsResults indicate a substantial correlation between vaccination and a 20% reduction in the risk of case-fatality. Age-specific effects reveal varying degrees of protection across different age groups.ConclusionThese findings emphasize the pivotal role of vaccination status in COVID-19 risk assessment, supporting the development of a clinical decision support system for accurate predictions and optimizing healthcare management at admission.

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How Does Vaccination against SARS-CoV-2 Affect Hospitalized Patients with COVID-19?

Cited by 5 publications

References 17 publications

Investigating the trend of demographic changes, mortality, clinical and paraclinical findings of patients hospitalized in the Corona ward, before and after the start of general vaccination of COVID-19

Investigating the trend of demographic changes, mortality, clinical and paraclinical findings of patients hospitalized in the Corona ward, before and after the start of general vaccination of COVID-19

Vaccination significantly reduced the length of SARS-CoV-2 viral clearance: A story from international healthcare workers

Assessing the impact of vaccines on COVID-19 efficacy in survival rates: a survival analysis approach for clinical decision support

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