How Effective Are Antimicrobial Agents on Preventing the Adhesion of Candida albicans to Denture Base Acrylic Resin Materials? A Systematic Review

Abstract

Denture stomatitis is a common oral infection caused by Candid albicans. It occurs under removable dentures due to several causative and contributing factors. If not treated, it can lead to fatal systemic candida infections. Different materials and techniques have been used to treat denture stomatitis; however, no single treatment has succeeded. The purpose of this study was to review novel techniques for incorporating antimicrobial and protein repellent agents into denture acrylic resin materials and their effect on the adhesion of Candida albicans to denture base acrylic resin materials to prevent and/or treat denture stomatitis. A systematic review was conducted in which an electronic search was undertaken using different databases and relevant keywords. The literature search revealed numerous studies describing different antifungal materials incorporated into different denture acrylic resin materials. The investigated materials showed significant antimicrobial activity with slight or no effect on the physical and mechanical properties; however, the optical properties were particularly affected with higher concentrations. The incorporation of antimicrobial agents to reduce or prevent Candida albicans biofilm formation on acrylic resin proved to be very effective, and this effect was found to be proportional to the percentage of the material used. The latter should be considered carefully not to alter the physical, mechanical or optical characteristics of the denture base material.

Zinc-modified phosphate-based glass micro-filler improves Candida albicans resistance of auto-polymerized acrylic resin without altering mechanical performance

“…However, it has little or no antimicrobial activity. A recent systematic review detailed different antimicrobial additives for C. albicans 37 . The addition of agents such as silver zeolites, silver nanoparticles and silicate-based bioactive glass to denture base acrylic resin enhances their fungal resistance 37 .…”

“…A recent systematic review detailed different antimicrobial additives for C. albicans 37 . The addition of agents such as silver zeolites, silver nanoparticles and silicate-based bioactive glass to denture base acrylic resin enhances their fungal resistance 37 . Therefore, the fabrication of an auto-polymerized acrylic resin with antimicrobial properties would be of great clinical benefit.…”

“…A recent systematic review detailed different antimicrobial additives for C.albicans 37 . The addition of agents such as silver zeolites, silver nanoparticles and silicate-based bioactive glass to denture base acrylic resin enhances their fungal resistance 37 . Therefore, the The results of the present study agrees with that of the previous studies, which validate the use of Zn-PBG as a high-density filler for enhancing anti-microbial properties without a tangible of mechanical properties.…”

Changes in the Surface Texture of Thermoplastic (Monomer-Free) Dental Materials Due to Some Minor Alterations in the Laboratory Protocol—Preliminary Study

“…Attempting to improve the polyamide materials’ surface characteristics so that a surface with better anti-microbial [ 23 ] and bacterial attack inhibition effects is obtained, as well as a reduction in microbial activity [ 24 , 25 , 26 , 27 , 28 , 29 , 30 ], the authors altered some of the factors in the injection molding process. These factors and conditions are interdependent and mutually affecting.…”

Effect of Candida albicans Suspension on the Mechanical Properties of Denture Base Acrylic Resin

“…As a result, the research on denture base materials in terms of their colonization by microorganisms and finding effective methods to counteract this colonization are among the most important in the area. Despite many attempts to provide materials with antifungal properties and the use of cleaning agents, this problem has not been solved due to its negative influence on the mechanical and/or aesthetic properties of the materials [ 7 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ], and the limited antimicrobial effectiveness of cleaning agents [ 18 ] associated with rapid recolonization (several minutes) after cleaning [ 19 ].…”