The core driving force behind innovation in intelligent construction technology is synergistic relationships. It has become common practice to promote synergistic innovation through agent interaction and knowledge coupling in the development of intelligent construction technology. Drawing upon synergetics, social network theory, and the knowledge base view as theoretical frameworks, this research examines the impact of synergistic relationship, agent interaction, and knowledge coupling on innovation in intelligent construction technology. An empirical analysis of 186 questionnaires revealed the following: (1) regarding synergistic relationships, both horizontal synergy and vertical synergy significantly positively impact innovation in intelligent construction technology. (2) Concerning agent interaction, strong interaction serves as a mediator between horizontal synergy and innovation in intelligent construction technology, while weak interaction serves as a mediator between vertical synergy and innovation in intelligent construction technology. (3) Knowledge coupling has a positive moderating effect on innovation in intelligent construction technology under a strong interaction and a negative moderating effect on innovation in intelligent construction technology under a weak interaction. This study contributes to expanding the theory of synergistic relationships and its application in the context of intelligent construction technology. Furthermore, it provides practical insights and guidance for construction companies seeking to enhance innovation in intelligent construction technology through the utilization of agent interaction and knowledge coupling.