How Far Can Mitochondrial DNA Drive the Disease?

Sun, Hongzhi; Shi, Weibin; Wang, Xiangdong

doi:10.1007/978-981-10-6674-0_1

Cited by 6 publications

(4 citation statements)

References 34 publications

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“…This genome is about 16.5 kb in humans, and 13 proteins and rRNAs are synthesised from the mitochondrial genome in mammals [19,20]. Therefore, the slightest change in mitochondrial genome can potentially affect the life of the cell, and thus the organism [21].…”

Section: Mitochondrial Methylationmentioning

confidence: 99%

Logic of Epigenetics and Investigation of Potential Gene Regions

Budak¹

2020

Chromatin and Epigenetics

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In living organisms, all molecular structures are formed, and all events are carried out by specific DNA sequences referred to as ‛genes'. However, these genes need to be governed and controlled to function properly. In this way, they can participate in biological processes at the optimal time. Genes are actively controlled by other genes and specific proteins called ‛transcription factors'. In addition, there is another mechanism that determines gene expression, which can be transmitted from generation to generation and from cell to cell. This mechanism is referred to as the ‛epigenetic code'. The DNA sequence does not undergo any changes during the formation of this code, but the relevant part of DNA fragment becomes no longer meaningful. While histone modifications control expression of DNA in chromosome structure, methylation modifications at the gene level are quite effective in controlling expressions the cytosine-end methylation seen in mammalian genome often occurs in the nucleotide pairs which are also called the CpG dinucleotides. The most common epigenetic modifications are the changes in histone proteins and DNA methylation, and the most widely studied and the most wellestablished epigenetic mechanism is the latter.

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Section: Mitochondrial Methylationmentioning

confidence: 99%

Logic of Epigenetics and Investigation of Potential Gene Regions

Budak¹

2020

Chromatin and Epigenetics

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“…Mitochondria can be an important control driver in the production of cell energy regulated by the MtDNA. MtDNA acts as the command control center to schedule energetic productions and maintain cell metabolisms and molecular diversification within the mitochondria, responsible for the development of diseases (Sun et al 2017;Lv et al 2017). It is clear that the mitochondria function as the energy motor and control a series of organelle responses and signal pathways in CBT, while a large number of intracellular or extracellular elements can influence, regulate, or control the mitochondrial function.…”

Section: Thinking Of Mitochondrial Dnamentioning

confidence: 99%

The role of mitochondria in cellular toxicity as a potential drug target

Wang

Sun

2018

Cell Biol Toxicol

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Mitochondrial malfunction is related to aging and to the onset of many diseases, such as obesity/diabetes, cancer, and cardiovascular and neurodegenerative diseases. The molecular principles of biological and toxicological processes the mitochondria can regulate should be disease-specific, cell type-specific, and drug targetable. Mitochondrial biology and toxicology is evolving and undergoing a revolution through fast-developing biotechnologies garnering increasing attention due to the importance of targeted therapies. Mitochondrial energy production and metabolism are conducted via post-mitochondrial signaling, and are controlled by extra-mitochondrial pathways. Mitochondrial biology and toxicology has a history spanning over 30 years and is one of the main scientific focuses at Cell Biology and Toxicology. It is our aim to pioneer innovations of mitochondrial biology and toxicology to improve the understanding, highlight the latest development, and find mitochondria-based targets for therapies. It is expected to know how drugs can initiate mitochondrial dysfunction, the role of nuclear messages in regulating mitochondrial DNA (MtDNA), and how mitochondria communicate between or with other cells. Further studies are crucial to discover how mitochondria control the process of immune response, autophagy/mitophagy, genome activation, and cell interaction. It is also needed to innovate how the transcription is started and terminated within mitochondria, the cytosolic proteins and other organelles interact with mitochondria, and MtDNA regulates the function of mitochondrial respiratory megacomplexes.

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“…Since mitochondria are dominant organelles regarding intracellular energy and because they have their own independent DNA genome, it is important to look at the genomic alterations of this organelle in certain diseases. These alterations are associated particularly with various pulmonary diseases and lung cancers [57,58].…”

Section: Mitochondrial Methylationmentioning

confidence: 99%

Epigenetic Modifications and Potential Treatment Approaches in Lung Cancers

Budak¹,

Yıldız²

2018

Lung Cancer - Strategies for Diagnosis and Treatment

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Alteration of methylation is a process seen across a wide variety of species ranging from bacterial microorganisms to mammals, defined as the adaptation method the organism develops against environmental or intrinsic effects, or employs to switch off the genome regions which are no longer required through the evolutionary process. Scientific advancements have allowed detecting the regions that undergo different patterns of methylation. It has been demonstrated that the control on changes in gene expression is not guided by transcription factors alone and that epigenetic alterations are also involved in this process. Furthermore, epigenetic modifications have been shown to be considerably important in cancer development. This section focuses on epigenetic changes and potential treatment options in lung cancer.

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How Far Can Mitochondrial DNA Drive the Disease?

Cited by 6 publications

References 34 publications

Logic of Epigenetics and Investigation of Potential Gene Regions

Logic of Epigenetics and Investigation of Potential Gene Regions

The role of mitochondria in cellular toxicity as a potential drug target

Epigenetic Modifications and Potential Treatment Approaches in Lung Cancers

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