How generalisable are material extrusion additive manufacturing parameter optimisation studies? A systematic review

Golab, Mark; Massey, Sam; Moultrie, James

doi:10.1016/j.heliyon.2022.e11592

Cited by 9 publications

(5 citation statements)

References 164 publications

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“…However, the lack of reproducibility associated with these conventional techniques represents the main limitation of these methodologies. On the contrary, additive manufacturing techniques, including Melt Extrusion Additive Manufacturing (MEAM), have garnered attention due to their versatility in fabricating complex microscale substrates with high reproducibility [27][28][29]. Recently, a combination of MEAM with porogen leaching has been investigated to fabricate three-dimensional polymeric scaffolds with a fibrous structure and anisotropic morphology [30,31].…”

Section: Introductionmentioning

confidence: 99%

Three-Dimensional Microfibrous Scaffold with Aligned Topography Produced via a Combination of Melt-Extrusion Additive Manufacturing and Porogen Leaching for In Vitro Skeletal Muscle Modeling

Spedicati,

Zoso,

Mortati

et al. 2024

Bioengineering

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Skeletal muscle tissue (SMT) has a highly hierarchical and anisotropic morphology, featuring aligned and parallel structures at multiple levels. Various factors, including trauma and disease conditions, can compromise the functionality of skeletal muscle. The in vitro modeling of SMT represents a useful tool for testing novel drugs and therapies. The successful replication of SMT native morphology demands scaffolds with an aligned anisotropic 3D architecture. In this work, a 3D PCL fibrous scaffold with aligned morphology was developed through the synergistic combination of Melt-Extrusion Additive Manufacturing (MEAM) and porogen leaching, utilizing PCL as the bulk material and PEG as the porogen. PCL/PEG blends with different polymer ratios (60/40, 50/50, 40/60) were produced and characterized through a DSC analysis. The MEAM process parameters and porogen leaching in bi-distilled water allowed for the development of a micrometric anisotropic fibrous structure with fiber diameters ranging from 10 to 100 µm, depending on PCL/PEG blend ratios. The fibrous scaffolds were coated with Gelatin type A to achieve a biomimetic coating for an in vitro cell culture and mechanically characterized via AFM. The 40/60 PCL/PEG scaffolds yielded the most homogeneous and smallest fibers and the greatest physiological stiffness. In vitro cell culture studies were performed by seeding C2C12 cells onto a selected scaffold, enabling their attachment, alignment, and myotube formation along the PCL fibers during a 14-day culture period. The resultant anisotropic scaffold morphology promoted SMT-like cell conformation, establishing a versatile platform for developing in vitro models of tissues with anisotropic morphology.

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Section: Introductionmentioning

confidence: 99%

Three-Dimensional Microfibrous Scaffold with Aligned Topography Produced via a Combination of Melt-Extrusion Additive Manufacturing and Porogen Leaching for In Vitro Skeletal Muscle Modeling

Spedicati,

Zoso,

Mortati

et al. 2024

Bioengineering

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“…In an attempt to solve conventional manufacturing problems, dentistry has moved into Industrial Revolution 4.0, aiming to improve the efficiency and productivity of its processes [ [45] , [46] , [47] , [48] ]. The digital age has become increasingly more significant in the dental sector, and with the advent of innovative technologies, there are many new areas and technological possibilities that could provide solutions to overcome the current limitations [ [49] , [50] , [51] ]. As a first step towards innovation and modernization, sports dentistry has extensively incorporated the use of intraoral scanning to obtain digital models [ 51 ].…”

Section: Introductionmentioning

confidence: 99%

The production and materials of mouthguards: Conventional vs additive manufacturing - A systematic review

Dias Gonçalves,

Fontes Vieira,

Colorado Lopera

2024

Heliyon

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“…Sometimes, the results present contradictory conclusions. In this regard, Golab et al 7 reviewed the primary literature in which the authors concluded "a lack of agreement among studies limits the generalisability of these parameter optimisation findings. "…”

Section: Introductionmentioning

confidence: 99%

“…6 Thus, multiple industries and nonindustrial users employ the technology. 7 Despite the popularity of material extrusion, the technology still lacks the desired qualities of traditional manufacturing processes in aspects such as part quality, dimensional and geometric conformity, tolerances, surface finish, and mechanical properties. 8 Poor surface quality is one of the main drawbacks.…”

Section: Introductionmentioning

confidence: 99%

Examining the surface quality of inner and outer surfaces in material extrusion printed samples

Río

Carou

Pereira

2023

Proceedings of the Institution of Mechanical Engineers, Part L:

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This article presents an experimental study of the material extrusion process to examine the impact of less-analyzed factors on surface roughness, not including the commonly known layer height. The study also gives attention to the inner surfaces of printed samples. The design of experiments used a fractional factorial design with five two-level factors: bed temperature, fan percentage, printing speed, printing temperature, and wall thickness. Thus, the purpose of the design is screening. A two-dimensional contact profilometer was used to measure the surface roughness. Generally, the inner faces of the printed samples showed lower surface roughness. In addition, four analysis of variance showed that wall thickness (for Ra and Rz) and printing speed (for Ra) are significant for the outer and inner surfaces, respectively. As the wall thickness increased, the surface roughness decreased. Meanwhile, the lower the printing speed, the worse the surface quality on the inner faces.

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How generalisable are material extrusion additive manufacturing parameter optimisation studies? A systematic review

Cited by 9 publications

References 164 publications

Three-Dimensional Microfibrous Scaffold with Aligned Topography Produced via a Combination of Melt-Extrusion Additive Manufacturing and Porogen Leaching for In Vitro Skeletal Muscle Modeling

Three-Dimensional Microfibrous Scaffold with Aligned Topography Produced via a Combination of Melt-Extrusion Additive Manufacturing and Porogen Leaching for In Vitro Skeletal Muscle Modeling

The production and materials of mouthguards: Conventional vs additive manufacturing - A systematic review

Examining the surface quality of inner and outer surfaces in material extrusion printed samples

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