How hydrophobically modified chitosans are stabilized by biocompatible lipid aggregates

Ruocco, Nino; Frielinghaus, Henrich; Vitiello, Giuseppe; D’Errico, Gerardino; Leal, L. Gary; Richter, Dieter; Ortona, Ornella; Paduano, Luigi

doi:10.1016/j.jcis.2015.03.058

Cited by 14 publications

(12 citation statements)

References 60 publications

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“…As reference, the EPR spectra of 5-DSA and 16-DSA in pure 18LPC lipid aggregates are also reported. Particularly, 5-DSA spectra present a clearly defined axially anisotropic lineshape, as generally observed for vesicles [43]. On the other hand, the higher isotropy of the 16-DSA spectra with respect to those obtained for The EPR spectra lineshape is also influenced by both the local polarity experienced by the label and its rotational mobility, as determined by the microenvironment viscosity and the structural order.…”

Section: Epr Analysissupporting

confidence: 61%

“…EPR spectra were recorded with a 9 GHz Bruker Elexys E-500spectrometer (Bruker, Rheinstetten, Germany an almost isotropic three-line spectrum when embedded in micelles [42,43], while a well-resolved anisotropic line shape is observed for vesicles [43]. A quantitative analysis of n-DSA spectra for all lipid samples was realized determining the acyl chain order parameters relative to the bilayer normal, S, and the isotropic hyperfine coupling constants for the spin-labels in the membrane, N ′ a , through a home-made MATLAB-based software routine.…”

Section: Electron Paramagnetic Resonance (Epr)mentioning

confidence: 99%

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Structural organization of lipid-functionalized-Au nanoparticles

Luchini

D’Errico

Leone

et al. 2018

Colloids and Surfaces B: Biointerfaces

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Gold nanoparticles (AuNPs) are considered suitable systems for drug delivery and diagnostics with several applications in biomedicine. Size, shape and surface functionalization of these nanoparticles are important parameters influencing their behavior in a biological environment. This study describes the preparation and the characterization of lysophosphocholine coated AuNPs by means of Small Angle Neutron Scattering (SANS), Electron Paramagnetic Resonance (EPR) and Fluorescence Spectroscopy. In particular the structure of the functionalized AuNP suspension, as well as the physical properties, of the nanoparticle organic coating are discussed. The experimental results indicated that functionalized lysophosphocholine-AuNPs form aggregates, which are composed by nanoparticles with core-shell structure. Nevertheless, the nanoparticle suspension resulted to be stable, without significant structural rearrangements even when the temperature was increased to 50 °C. At the same time, experimental evidences also suggested that the 18LPC layer around AuNPs presented a reduced chain packing compared to pure 18LPC aggregates.

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Section: Epr Analysissupporting

confidence: 61%

Section: Electron Paramagnetic Resonance (Epr)mentioning

confidence: 99%

Structural organization of lipid-functionalized-Au nanoparticles

Luchini

D’Errico

Leone

et al. 2018

Colloids and Surfaces B: Biointerfaces

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“…In addition, the ability of self-aggregation to form micelles and the adsorption capacity of hydrophobic drugs can be controlled by adjusting the DS of alkyl chain and the chain length. [17][18][19][20] Therefore, NACS can be used as a carrier of hydrophobic drugs to improve the stability of drugs and facilitate the delivery and release of hydrophobic drugs.…”

Section: Discussionmentioning

confidence: 99%

Synthesis of N-alkylated Chitosan and its Aggregation Behavior

Zhang¹,

Deng²,

Guan³

et al. 2018

Proceedings of the 4th Annual International Conference on Material Engineering and Application (ICMEA 2017)

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“…A Figura 51 apresenta a dependência da viscosidade dinâmica (μ) dos hidrogéis de N,O-mPEG-g-quitosana em função da taxa de cisalhamento ( ). Em todos os casos é observada a diminuição da viscosidade devido ao alinhamento das cadeias, resultando na diminuição da resistência ao fluxo submetido, conforme o aumento da taxa de cisalhamento (CONTRI et al, 2014;RUOCCO et al, 2015). É possível inferir que elevados teores de unidades GlcN favorecem interações de curto alcance (ligações hidrogênio), as quais atuam de forma efetiva sobre a fricção hidrodinâmica das cadeias, resultando em maiores valores de viscosidade dinâmica e pronunciado comportamento pseudoplástico dos hidrogéis PgQD3x ( ̅̅̅̅ = 52,3 ± 0,7 %) e PgQ ( ̅̅̅̅ = 65,5 ± 0,7 %).…”

Section: Ensaios Reológicos Em Fluxounclassified

“…Conforme o aumento da frequência, a aproximação das curvas G' e G'' versus frequência indica o rompimento e a diminuição das estruturas em rede polimérica dos hidrogéis (CHENITE et al, 2001;KONO;TESHIROGI, 2015;RUOCCO et al, 2015).…”

Section: Ensaios Reológicos Em Fluxounclassified

Preparação e caracterização de nanosuspensões e hidrogéis de <i>N,O</i>-metoxipoli(etilenoglicol)-<i>g</i>-quitosana para aplicação em sistemas de liberação de fármacos antitumorais

Facchinatto¹

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Data from National Institute of Cancer show an increase of 14.1 million new cases of cancer over the world in 2012, and the estimate for 2014/2015 in Brazil points to over 500,00 new cases. Thus, research focused on the production of nanoparticles and hydrogels, consisting by natural or synthetic polymers, are important for the development of systems for controlled release of antitumoral drugs. Therefore, this study aimed to produce systems based on hydrophilic derivative of chitosan, N,O-methoxy(polyethyleneglycol)-g-chitosan, for the encapsulation and release of antitumor drugs. The structural and physicochemical characteristics of the chitosan and the polymers were analyzed by FTIR, 1 H NMR, solubility as function of pH, viscosimetry, XRD and TGA. The parent chitosan with different average degrees of deacetylation and viscosimetric average molecular weight, QD1x (

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How hydrophobically modified chitosans are stabilized by biocompatible lipid aggregates

Cited by 14 publications

References 60 publications

Structural organization of lipid-functionalized-Au nanoparticles

Structural organization of lipid-functionalized-Au nanoparticles

Synthesis of N-alkylated Chitosan and its Aggregation Behavior

Preparação e caracterização de nanosuspensões e hidrogéis de <i>N,O</i>-metoxipoli(etilenoglicol)-<i>g</i>-quitosana para aplicação em sistemas de liberação de fármacos antitumorais

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