How late in pregnancy can fetal physiological omphalocele be seen? Nationwide study of cases in Denmark over 4‐year period

Hornstrup, Louise Stig; Kristensen, S E; Nørgaard, P; Sperling, Lene; Sandager, Puk; Ibsen, Mette Holm; Jørgensen, Finn Stener

doi:10.1002/uog.24937

Cited by 2 publications

(4 citation statements)

References 6 publications

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“…It is important to note that some ultrasonographic findings may be concerning in the first trimester such as mega-cystis (bladder length 7-15 mm), bowel containing omphaloceles, intra-abdominal cysts or fluid collections, and some cardiac anomalies in euploid fetuses that may potentially resolve without adverse outcomes. 53,59,[91][92][93] As would be expected from embryologic development, some malformations are almost never detected in the first trimester, including agenesis of the corpus callosum, microcephaly, lissencephaly, and congenital pulmonary malformations 53 (Table 2).…”

Section: Congenital Anomalies Detected In the First Trimestermentioning

confidence: 97%

“…39,57 False-positive and false-negative imaging findings may occur in any screening program, related to the natural history of the observed finding or the experience of the performing and interpreting clinicians. [58][59][60] When these cases arise, it is imperative that a retrospective review of images for quality assessment and practice improvement be conducted.…”

Section: Early Anatomic Imaging Protocolsmentioning

confidence: 99%

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First-Trimester Ultrasound Screening in Routine Obstetric Practice

Bromley,

Platt

2024

Obstetrics &Amp; Gynecology

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Technologic advances and ultrasonographer–physician experience in fetal imaging have led to significant improvements in our ability to distinguish between normal and abnormal fetal structural development in the latter part of the first trimester. As a critical component of pregnancy care, assessment of fetal anatomy at the end of the first trimester with a standardized imaging protocol should be offered to all pregnant patients regardless of aneuploidy screening results because it has been demonstrated to identify approximately half of fetal structural malformations. Early identification of abnormalities allows focused genetic counseling, timely diagnostic testing, and subspecialist consultation. In addition, a normal ultrasound examination result offers some degree of reassurance to most patients. Use of cell-free DNA alone for aneuploidy screening while foregoing an accompanying early anatomic evaluation of the fetus will result in many anomalies that are typically detected in the first trimester not being identified until later in pregnancy, thus potentially diminishing the quality of obstetric care for pregnant individuals and possibly limiting their reproductive options, including pregnancy termination.

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Section: Congenital Anomalies Detected In the First Trimestermentioning

confidence: 97%

Section: Early Anatomic Imaging Protocolsmentioning

confidence: 99%

First-Trimester Ultrasound Screening in Routine Obstetric Practice

Bromley,

Platt

2024

Obstetrics &Amp; Gynecology

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“…However, although some researchers have attempted to define when this is no longer physiologic based on size and/or gestational age, the cutoffs are not yet so clear and recent data indicate that this finding can persist into the early second trimester and still be associated with a normal outcome. 25 Likewise, there are many observations that can be made early in gestation that are of uncertain significance. Abdominal cysts, an asymmetric or irregular choroid plexus, or an enlarged bladder can all be seen in a fetus that ultimately is found to be normal.…”

Section: Earlier Detection Of Severe Fetal Anomaliesmentioning

confidence: 99%

“…A physiologic herniation of the fetal bowel into the base of the umbilical cord is known to be a normal finding until about 12 weeks' gestation(Figure 1). However, although some researchers have attempted to define when this is no longer physiologic based on size and/or gestational age, the cutoffs are not yet so clear and recent data indicate that this finding can persist into the early second trimester and still be associated with a normal outcome 25 …”

Section: The Case Against (Mary Norton)mentioning

confidence: 99%

ISPD 2022 debate—When offering a first trimester ultrasound at 11 + 0 to 13 + 6 weeks, a detailed review of fetal anatomy should be included

2022

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Key points What is already known about this topic? Through the introduction of the nuchal translucency scan at 11 + 0 to 13 + 6 weeks gestation for aneuploidy screening in the 1990s, the role of the first trimester scan has evolved to include an assessment of fetal anatomy. Advances in ultrasound technology and expertise now mean that many fetal anomalies that were previously detected on the routine second trimester anatomy scan are now detected in the first trimester. What does this study add? This report summarizes the oral debate that was presented at the 22nd International Conference on Prenatal Diagnosis and Therapy in Montreal, Canada, on 21 June 2022. Our maternal–fetal medicine experts argue for and against the proposition that a detailed review of fetal anatomy should be included in all scans performed at 11 + 0 to 13 + 6 weeks gestation.

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How late in pregnancy can fetal physiological omphalocele be seen? Nationwide study of cases in Denmark over 4‐year period

Cited by 2 publications

References 6 publications

First-Trimester Ultrasound Screening in Routine Obstetric Practice

First-Trimester Ultrasound Screening in Routine Obstetric Practice

ISPD 2022 debate—When offering a first trimester ultrasound at 11 + 0 to 13 + 6 weeks, a detailed review of fetal anatomy should be included

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