How many brain regions are needed to elucidate the neural bases of fear and anxiety?

Pessoa, Luiz

doi:10.1016/j.neubiorev.2023.105039

Cited by 15 publications

(12 citation statements)

References 42 publications

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“…The SUITAS provides evidence that the subjective experience of uncertain threat anticipation involves distributed neural systems 75 , which resembles current observations in animal models that the response to uncertain threats recruits a distributed array of interconnected neural ensembles 10 . Further analyses demonstrated that no single region or network was sufficient for predicting anxious experience, which aligns with predictive modeling results for other subjective emotional experiences 21,52 and argues against the traditional structure-centric view 70,71 but rather suggests a constructionist theory of emotion 48,49 .…”

Section: Discussionsupporting

confidence: 62%

A neural signature for the subjective experience of threat anticipation under uncertainty

Liu,

Jiao,

Zhou

et al. 2023

Preprint

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Uncertainty about potential future threats and the associated anxious anticipation represents a key feature of anxiety. However, the neural systems that underlie the subjective experience of threat anticipation under uncertainty remain unclear. Combining a novel uncertain shock anticipation paradigm that allows precise modulation of the level of momentary anxious arousal during functional magnetic resonance imaging (fMRI) with multivariate predictive modeling, we trained a brain model that accurately predicted the intensity of subjective experience of anxious arousal on the population and individual level. In a series of analyses utilizing available fMRI datasets, we further demonstrate that the signature specifically predicted anxious anticipation and was not sensitive in predicting pain, general anticipation or unspecific arousal. The signature was functionally and spatially distinguishable from representations of subjective fear or negative affect. We developed a sensitive, generalizable, and specific neuromarker for subjective anxious arousal experienced during uncertain threat anticipation that can facilitate model development and clinical translation.

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Section: Discussionsupporting

confidence: 62%

A neural signature for the subjective experience of threat anticipation under uncertainty

Liu,

Jiao,

Zhou

et al. 2023

Preprint

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“…Amygdala is the key component of the neural circuitry of fear. , Shumyatsky et al reported that GRPR is expressed by GABAergic interneurons in lateral nucleus of amygdala (LA), and GRP mRNA was enriched in brain regions including medial geniculate body, posterior intralaminar nucleus, and auditory cortex, which connect with LA and send auditory signals into amygdala during fear memory formation . Besides, GRP mRNA was also detected in the principal neurons of LA .…”

Section: Functions Modulated By Grp/grpr Systemmentioning

confidence: 99%

Role of the GRP/GRPR System in Regulating Brain Functions

Zhao,

Chen,

Dai

et al. 2023

ACS Chem. Neurosci.

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“…No study to our knowledge, however, has specifically addressed this question. Moreover, past research has examined functional activation magnitude in brain regions, but brain regions do not activate in isolation—brain regions work together as functional neuronal assemblies (e.g., see Pessoa, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Language access differentially alters functional connectivity during emotion perception across cultures

Leshin,

Carter,

Doyle

et al. 2024

Front. Psychol.

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IntroductionIt is often assumed that the ability to recognize the emotions of others is reflexive and automatic, driven only by observable facial muscle configurations. However, research suggests that accumulated emotion concept knowledge shapes the way people perceive the emotional meaning of others’ facial muscle movements. Cultural upbringing can shape an individual’s concept knowledge, such as expectations about which facial muscle configurations convey anger, disgust, or sadness. Additionally, growing evidence suggests that access to emotion category words, such as “anger,” facilitates access to such emotion concept knowledge and in turn facilitates emotion perception.MethodsTo investigate the impact of cultural influence and emotion concept accessibility on emotion perception, participants from two cultural groups (Chinese and White Americans) completed a functional magnetic resonance imaging scanning session to assess functional connectivity between brain regions during emotion perception. Across four blocks, participants were primed with either English emotion category words (“anger,” “disgust”) or control text (XXXXXX) before viewing images of White American actors posing facial muscle configurations that are stereotypical of anger and disgust in the United States.ResultsWe found that when primed with “disgust” versus control text prior to seeing disgusted facial expressions, Chinese participants showed a significant decrease in functional connectivity between a region associated with semantic retrieval (the inferior frontal gyrus) and regions associated with semantic processing, visual perception, and social cognition. Priming the word “anger” did not impact functional connectivity for Chinese participants relative to control text, and priming neither “disgust” nor “anger” impacted functional connectivity for White American participants.DiscussionThese findings provide preliminary evidence that emotion concept accessibility differentially impacts perception based on participants’ cultural background.

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How many brain regions are needed to elucidate the neural bases of fear and anxiety?

Cited by 15 publications

References 42 publications

A neural signature for the subjective experience of threat anticipation under uncertainty

A neural signature for the subjective experience of threat anticipation under uncertainty

Role of the GRP/GRPR System in Regulating Brain Functions

Language access differentially alters functional connectivity during emotion perception across cultures

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