How many scientific papers are not original?

Lesk, Michael

doi:10.1073/pnas.1422282112

Cited by 23 publications

(17 citation statements)

References 8 publications

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“…Specifically, among other physiological changes, housing mice at T N , as opposed to T S , (a) reduces sustained sympathetic nervous system activation—associated with decreased heart rate, (b) enhances the immune response to a variety of pathogens (typhus, rhinovirus, LPS, etc.) and tumors, and (c) augments obesity development [8], [10], [12], [13], [14], [15], [16], [17].…”

Section: Introductionmentioning

confidence: 99%

Modulation of ambient temperature promotes inflammation and initiates atherosclerosis in wild type C57BL/6 mice

Giles

Ramkhelawon

Donelan

et al. 2016

Molecular Metabolism

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ObjectivesObesity and obesity-associated inflammation is central to a variety of end-organ sequelae including atherosclerosis, a leading cause of death worldwide. Although mouse models have provided important insights into the immunopathogenesis of various diseases, modeling atherosclerosis in mice has proven difficult. Specifically, wild-type (WT) mice are resistant to developing atherosclerosis, while commonly used genetically modified mouse models of atherosclerosis are poor mimics of human disease. The lack of a physiologically relevant experimental model of atherosclerosis has hindered the understanding of mechanisms regulating disease development and progression as well as the development of translational therapies. Recent evidence suggests that housing mice within their thermoneutral zone profoundly alters murine physiology, including both metabolic and immune processes. We hypothesized that thermoneutral housing would allow for augmentation of atherosclerosis induction and progression in mice.MethodsApoE−/− and WT mice were housed at either standard (TS) or thermoneutral (TN) temperatures and fed either a chow or obesogenic “Western” diet. Analysis included quantification of (i) obesity and obesity-associated downstream sequelae, (ii) the development and progression of atherosclerosis, and (iii) inflammatory gene expression pathways related to atherosclerosis.ResultsHousing mice at TN, in combination with an obesogenic “Western” diet, profoundly augmented obesity development, exacerbated atherosclerosis in ApoE−/− mice, and initiated atherosclerosis development in WT mice. This increased disease burden was associated with altered lipid profiles, including cholesterol levels and fractions, and increased aortic plaque size. In addition to the mild induction of atherosclerosis, we similarly observed increased levels of aortic and white adipose tissue inflammation and increased circulating immune cell expression of pathways related to adverse cardiovascular outcome.ConclusionsIn sum, our novel data in WT C57Bl/6 mice suggest that modulation of a single environmental variable, temperature, dramatically alters mouse physiology, metabolism, and inflammation, allowing for an improved mouse model of atherosclerosis. Thus, thermoneutral housing of mice shows promise in yielding a better understanding of the cellular and molecular pathways underlying the pathogenesis of diverse diseases.

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Section: Introductionmentioning

confidence: 99%

Modulation of ambient temperature promotes inflammation and initiates atherosclerosis in wild type C57BL/6 mice

Giles

Ramkhelawon

Donelan

et al. 2016

Molecular Metabolism

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“…The study of radiative cooling has a long history123456789101112131415161718192021. It has been well known since ancient times, that a black radiator facing a clear night sky can reach sub-ambient temperature16.…”

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confidence: 99%

Radiative cooling to deep sub-freezing temperatures through a 24-h day–night cycle

et al. 2016

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Radiative cooling technology utilizes the atmospheric transparency window (8–13 μm) to passively dissipate heat from Earth into outer space (3 K). This technology has attracted broad interests from both fundamental sciences and real world applications, ranging from passive building cooling, renewable energy harvesting and passive refrigeration in arid regions. However, the temperature reduction experimentally demonstrated, thus far, has been relatively modest. Here we theoretically show that ultra-large temperature reduction for as much as 60 °C from ambient is achievable by using a selective thermal emitter and by eliminating parasitic thermal load, and experimentally demonstrate a temperature reduction that far exceeds previous works. In a populous area at sea level, we have achieved an average temperature reduction of 37 °C from the ambient air temperature through a 24-h day–night cycle, with a maximal reduction of 42 °C that occurs when the experimental set-up enclosing the emitter is exposed to peak solar irradiance.

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“…Lucene 8 , a popular and freely available IR system, is used for the experiment. The source collection is indexed.…”

Section: B Implementationmentioning

confidence: 99%

“…[7] reported a summary of three different surveys in which 88%, 90% and 91.7% of the students admitted that they were involved in cheating or academic dishonesty at least once during their study. Plagiarism is not restricted to students, but has also surfaced amongst academics [8]. For example, Citron & Ginsberg [9] analyze text reuse within the ArXiv.org scientific corpus and Errami et al [10] identify duplication in PubMed abstracts.…”

Section: Introductionmentioning

confidence: 99%

An IR-Based Approach Utilizing Query Expansion for Plagiarism Detection in MEDLINE

Nawab

Stevenson

Clough

2017

IEEE/ACM Trans. Comput. Biol. and Bioinf.

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Abstract-The identification of duplicated and plagiarised passages of text has become an increasingly active area of research. In this paper we investigate methods for plagiarism detection that aim to identify potential sources of plagiarism from MEDLINE, particularly when the original text has been modified through the replacement of words or phrases. A scalable approach based on Information Retrieval is used to perform candidate document selection -the identification of a subset of potential source documents given a suspicious text -from MEDLINE. Query expansion is performed using the ULMS Metathesaurus to deal with situations in which original documents are obfuscated. Various approaches to Word Sense Disambiguation are investigated to deal with cases where there are multiple Concept Unique Identifiers (CUIs) for a given term. Results using the proposed IR-based approach outperform a state-of-the-art baseline based on Kullback-Leibler Distance.

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How many scientific papers are not original?

Cited by 23 publications

References 8 publications

Modulation of ambient temperature promotes inflammation and initiates atherosclerosis in wild type C57BL/6 mice

Modulation of ambient temperature promotes inflammation and initiates atherosclerosis in wild type C57BL/6 mice

Radiative cooling to deep sub-freezing temperatures through a 24-h day–night cycle

An IR-Based Approach Utilizing Query Expansion for Plagiarism Detection in MEDLINE

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